Basic Information

Insect: Agonum fuliginosum
Gene Symbol: egg_2
Assembly: GCA_947534325.1
Location: OX384047.1:7538510-7545242[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2 1.3e+04 -2.7 0.0 38 58 313 333 310 342 0.84

2 2 1.3e-12 8.4e-09 36.4 0.1 5 70 704 762 701 767 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2	1.3e+04	-2.7	0.0	38	58	313	333	310	342	0.84
2	2	1.3e-12	8.4e-09	36.4	0.1	5	70	704	762	701	767	0.89

Sequence Information

Coding Sequence: ATGAAAAATCTTCCAAAGGCAAATTCTAACCCTAACGCTGCCGAAATTGTTCTCCTAGACGAAGAGAACGAAGATAACCCTTCTGAAATGGTAGCTACAACATCAAACAGCAACAAAAGTGATCCAGAAGTTATAGATTTAGATAATTATGATATATTAGGAAAAAAGAAGCGAAAACGTTCAGCAAACAACAACTGTGTCAACATTGAATGCGAAAGCGGTGAGAAGTTGAGACCAGCTACAATATTTTGCTTGAATTACTACCGGATTAAGATCAAACCGCACAAAAACCAAGAAATCTGTGAGGAGTGTTACGAGAAAACTCTACTGTATTATGAGGAATTATCAAACAGCTTACAAAACGGCGAATGCCTCATCAATCAAAAACTTCCAACTCATGATGAATATGTCGAGATCGATTCTGATGATTCATCAGACGACATTTTAGATATTTGCGTCCCAGGTGTTACAAGCTGTAAAATATCAGATGAACTCAACGAATATCTAGCAACAGAACTTCCTGACATTCTCAATGAAGTAGTCGACAAATTCGACTTGGAAAATCAGTTAAATGAAGGTACAACTCTACTAGCAGAACGCCAAGACAAATTACAAGAAGGAATCGATAGTTTGTTTGCCGAAGAAAATGATTTACAAACTCGATTGGACAAAATACGTTCAGAGTTATACACAGAGTTCCAGAAAAAGTCTGAAGAGCTGCCTCCACTTGACTTGGACACAGAAGCACAACCTCTAGAAAAGTTAAATATCCAACCACAATCACCCAGAAAAGAAGCTGAGCGGCGCAGCCATCGAAATATCGCTAAACCCGCGTCGTACTGCGAAATCATCGAAGATGTTGACACTCCAGAAGTCGTTGCAATTCCGTCTACCAGTTTTGCAGAAATACAAACTCCAATACTAAATAACATCCCGCCGAGTGGCAAACTATTGAAAGCTAGGCCTCAAATCGGAGAAGTTTATTTCGCTCAAAGGCAATCCATATTCGGGGCGTGGGGCAAAGTCAAACTGCTAGAAATAGAAACTGTTGGTTCTATTCTTGCGAATTCAGGCAGCGCTGCTATAAATCCATCGGAAGAAACGGGCGCAGCGAATCAGATCAGTCTTCCAGACACTTCAGCGCCGACAATTCCAACGCCGGTGGTGCAAAATGCCGCGAATCTAATGTACAAGGTTCGGTTCGAGGGGAAGAAACATACGTCGACGAAGTATGTGACAGGGAAACAGCTCTCGTATCCGTATCCGGCGGATGTCAAGCTTGATGTTGGTACCAGAGTCATCGCGGTGTTCAATGACGAGCAGTTGCACAAGAAGGAAAGCTACTACGCTGGAATTATAGCAGAGCCGTTGTCCGTCACCAACCATTTTAGGTATTTGGTATTTTTTGATGATGGCTATGCGCAGTATGTCAACCATAATAAGGTTCTGGTAGTTTGTGAAAGTTCTAAGAACATTTGGGAAGATATTCATCCGGATTCACAGACGTTCATTAAGAAGTACTTAGAGACGTATCCGGAACGACCGTTAGTAAAAGTAAAACAAGATCAAGTGGTGAAGACAGAGTGGAACGGAAAGTGGTGGATCGGTCGGGTGTTAAGAGTCGATTGTAGTCTAGTTCACATGTATTTCGATGCAGATAACCGCAGTGAATGGATCTACAGAGGTTCTACGAGGCTTGGGCCATTATTCTTAGAGGTGCAAGCAGCAGCCGCACGGCAGGAAAAGGGGCCCCACATCCCTAAGATCCAGCAGAAGAGCAACAAGAACACGGCGGAGCCCTACGTGGAGTATCCTAAGCCACCGGAGGCGGACGCTACGATGGAAGTGACGCCGGTGGCTGCAGCTGCGGCTGAGCCCCCGGCGCCCCGCGCGGTCGCACGGAAGTCCACCACTAGGCCGCCCAACACCCTCCCTCAGCCGGTCAACATGGTGCCGTTCTTACCGACGCCGCAAGTCCAACAACCCCAAAGCAAAGTTGTGTATTTCACACCGAAATCAGTAAACCCTTTGAAGGCCTTCGTACCTCACACCTGCTCACCAGAGTGTTCTAAACTGGTTTCTCTACCTCTGGCAGCTCTGAAAGGCTACAACCCGCTATCAAAACCGCTTTTAATCGGCTGGCACAGACAACTATTTAAATACCGAGGCAAGAAGGGCATCAGATACCGCGCTCCATGCGGCAGAACCCTCCGCAACATGCCCGAACTGCACAAGTACTTACGTCTCACCCAATCGGAAATGTCGGTAGACAACTTCGATTTCGACTTTTGGGTTCACACTTTAGCGGAGTTTGTTCTCGATAAGACTTTCAGAAGCAAGCGAGACATTTCTAGTGGGGTGGAAAACGTGCCAATTCCTTGCGTGAACTATGTAGACGCCTCGATGCCTGATTTTATTAGTTATTCCACCAAACGCGAGCCGCAAGAAGGAGTCAATCTCAACTTGGACCCCGAGTTTCTCTGCGGTTGTGATTGTACTGATGATTGCAGTGATAAGACCAAATGCGCGTGCTGGCAGATGACAATTCGCGAGGCTAGAACGCTAAATAAACGAGTACCAGAAGAACTCATCGGATATACGTATAAACGTTTGCCTGATTGCGTCACTACCGGTATTTACGAATGTAACTCACGCTGCAAATGCGCCAAGACTTGCCTCAATCGTGTCGTGCAACATCCCTTGCAGTTAAAGTTGCAATTATTCAAGACTGCGAACCGTGGATGGGGCATTCGTTGCTTGAACGATATTCCACATGGCGCATTTATTTGTATATATGCCGGCTCCTTATTGACAGACAAAATGGCCAACGAGGGCGGTGTGAACTACGGTGACGAATATCTAGCAGAACTGGATTACATTGAAGTCGTTGAGCGTCAAAAAGATGGATATGAATCCGATGTGACCGATATAGAATCCGATAAAAATTCTAACAGCGACAACGATTCAGAGTTCGATGAATTCGAGCACAAAAACTATTCTAGCAAGTCTAGAAGCACAGTCACAACTCGAAGTAGATATCAAAGAGATGTCTCGCCGCCTAAGATATCTTCTCCGACTTCTGAAACTGTTACAATTTCAGACGACGAGGAAACAATTCGCGAAAAGTCGAGTTTTATTCCTTCCACTCAAACCGAGGACCAAATCCCGGTCTCCAAGTTCAAATCGGTTAGGAAAAtgttcggcgaggatgaagtatgctatattatggacgctaaaaacaccggaaatattgggaggtttctaaatCATAGTTGCAGCccaaatgtgttcgtacaaaacgtttttgtagacacgcacgatcttcggtttccgtgggttgcgtttttcgccatgaattacattcgagccggaacggaattaacttggaattacaactatgatgttggaagtgtccccggaaaagttattttctgtcattgcggtagccctgactgtagaggaaggttgttgtaa
Protein Sequence: MKNLPKANSNPNAAEIVLLDEENEDNPSEMVATTSNSNKSDPEVIDLDNYDILGKKKRKRSANNNCVNIECESGEKLRPATIFCLNYYRIKIKPHKNQEICEECYEKTLLYYEELSNSLQNGECLINQKLPTHDEYVEIDSDDSSDDILDICVPGVTSCKISDELNEYLATELPDILNEVVDKFDLENQLNEGTTLLAERQDKLQEGIDSLFAEENDLQTRLDKIRSELYTEFQKKSEELPPLDLDTEAQPLEKLNIQPQSPRKEAERRSHRNIAKPASYCEIIEDVDTPEVVAIPSTSFAEIQTPILNNIPPSGKLLKARPQIGEVYFAQRQSIFGAWGKVKLLEIETVGSILANSGSAAINPSEETGAANQISLPDTSAPTIPTPVVQNAANLMYKVRFEGKKHTSTKYVTGKQLSYPYPADVKLDVGTRVIAVFNDEQLHKKESYYAGIIAEPLSVTNHFRYLVFFDDGYAQYVNHNKVLVVCESSKNIWEDIHPDSQTFIKKYLETYPERPLVKVKQDQVVKTEWNGKWWIGRVLRVDCSLVHMYFDADNRSEWIYRGSTRLGPLFLEVQAAAARQEKGPHIPKIQQKSNKNTAEPYVEYPKPPEADATMEVTPVAAAAAEPPAPRAVARKSTTRPPNTLPQPVNMVPFLPTPQVQQPQSKVVYFTPKSVNPLKAFVPHTCSPECSKLVSLPLAALKGYNPLSKPLLIGWHRQLFKYRGKKGIRYRAPCGRTLRNMPELHKYLRLTQSEMSVDNFDFDFWVHTLAEFVLDKTFRSKRDISSGVENVPIPCVNYVDASMPDFISYSTKREPQEGVNLNLDPEFLCGCDCTDDCSDKTKCACWQMTIREARTLNKRVPEELIGYTYKRLPDCVTTGIYECNSRCKCAKTCLNRVVQHPLQLKLQLFKTANRGWGIRCLNDIPHGAFICIYAGSLLTDKMANEGGVNYGDEYLAELDYIEVVERQKDGYESDVTDIESDKNSNSDNDSEFDEFEHKNYSSKSRSTVTTRSRYQRDVSPPKISSPTSETVTISDDEETIREKSSFIPSTQTEDQIPVSKFKSVRKMFGEDEVCYIMDAKNTGNIGRFLNHSCSPNVFVQNVFVDTHDLRFPWVAFFAMNYIRAGTELTWNYNYDVGSVPGKVIFCHCGSPDCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00028754;
90% Identity: -
80% Identity: -