Aeri028608.1
Basic Information
- Insect
- Acraspis erinacei
- Gene Symbol
- Poxn
- Assembly
- GCA_035041075.1
- Location
- JAWWLR010000127.1:33784949-33798818[+]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 3.3e-19 2.6e-15 58.9 0.0 73 125 23 75 13 75 0.95 2 2 4.9 3.8e+04 -3.0 0.0 49 66 303 320 289 326 0.55
Sequence Information
- Coding Sequence
- ATGCCATCCACAGGTGAAGCGATCGGCAATCAGATAGTGTTGCTCGGAAATATCGAAATTGTGTTGCAGCAAGTTGCCACGCCAAGTGTTGTAAAGAAAATCCTGCGGATGAAACAGGAAAATCCTACTATGTTCGCATGGGAGATAAGGGAAGCACTGGCTCGACAGGGAGCTTGCGATCCTCAAAGCTTACCTTCCGTGTCTTCGGTCAACCGGATACTAAGGGGTGGAGGTTTACAAACTGAAAATTCTGGATTCGAGGGTGGATCTTCTACCACTTACCAGCCACAAATCCCCGCCCACGTTGGTGGAGTTAGAGAACCACTTCTTCGGGGTGATTATCAATTTTTCTACCCTGGAGCGTTGGGCCCACTGCACGTTTCGACTTCTGGAAATTCTGGAACGCCAACCTGGAATCCAACTTTTTATTCTTCTCTTTATCAAGCTACCACATTGCATTTGCATCACGGATCACAATCCCTGGACTCGGACCGACTCGTTGATCGTCAGGAGAGCCAATCTCAGGTGGAGTTGAAATCCAGTTCGAGTTCGATGGCCGGAAGCGACGACTCCCTGGACAACAGTGACCTGGACGAAACAACCGAGTCCCAGGACCACTTTAAACCTTACCAAAGATCTCCAATCATCCTCGAGCTGGGGCAAAAAGTTGGAAGCGAGCGGAGCGCCTTTGTGAGACACGTAGTTGGAAACCCAAAcgagaatttcgagaattcctctCGAAATCCTCCATCACCAGTGGAAAACCCACCTAGGAATCTCCTAACTCGAGGAACTTTCGGGGGCGAACAAAATTCCAGCGACGTCAGTACTGGCATTGAAAACCAACCGCCTCCAAGGAAGAAGAATCCTTACTCCATAGAAGAATTGTTGAAAAAGGACGAGACGAAAACGAGTTCAAAAAGGCCCAGGCTTCTTAATACTGGTGTCGTTCAACCCTGCGGCATCATCGTCGGAAAAGCAGTTTGA
- Protein Sequence
- MPSTGEAIGNQIVLLGNIEIVLQQVATPSVVKKILRMKQENPTMFAWEIREALARQGACDPQSLPSVSSVNRILRGGGLQTENSGFEGGSSTTYQPQIPAHVGGVREPLLRGDYQFFYPGALGPLHVSTSGNSGTPTWNPTFYSSLYQATTLHLHHGSQSLDSDRLVDRQESQSQVELKSSSSSMAGSDDSLDNSDLDETTESQDHFKPYQRSPIILELGQKVGSERSAFVRHVVGNPNENFENSSRNPPSPVENPPRNLLTRGTFGGEQNSSDVSTGIENQPPPRKKNPYSIEELLKKDETKTSSKRPRLLNTGVVQPCGIIVGKAV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01392717;
- 90% Identity
- iTF_00200705;
- 80% Identity
- -