Zmor010793.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Zophobas morio
Gene Symbol
Mef2
Assembly
GCA_027724725.1
Location
JALNTZ010000010.1:4118069-4120259[+]

Transcription Factor Domain

TF Family
SRF
Domain
SRF domain
PFAM
PF00319
TF Group
Helix-turn-helix
Description
Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.6e-28 5e-24 84.6 0.4 1 48 10 57 10 57 0.99

Sequence Information

Coding Sequence
ATGGGTCGCAAAAAAATACAAATATCGAGAATCACCGACGAACGGAATCGACAGGTTACTTTCAACAAACGGAAGTTCGGCGTGATGAAGAAGGCTTACGAGCTGTCGGTTTTGTGCGACTGCGAGATCGCTCTCATCATCTTCAGCAGCAGCAATAAATTGTATCAGTATGCCAGCACGGACATGGACAAAGTGTTACTCAAGTACACGGAATACAACGAGCCACACGAGTCTCTGACCAACAAAAATATTATCGAGGCACTTAATAAGAAAGAGCATAAGAACGGCGTGATGAGTCCTGACAGTCCGGAGCCGGAGACGGAATACCAGTTGACGCCGCGGACCGAAGCCAAATACAGCAAGATCGACGAGGAGTTCCAAATGATGCTTCAGAGAAACCAAATCAACGGACAAAGGGTCAGCATGAGTTCTTCAAATTACACCCAACCCGTCTCGGTGCCTGTTAACATAAGTTACGGTGATTCTGGTCTTCTTCAATCTAGTCCGCAAATGGCTCATACTAGTATTAGTCCTCGACCGTCTTCTTCGGAGACCGACTCGGTTTATCCGAGCGGCGGTATGCCCGAGATGAGCAACGGTTACCCGAATTCGGCGTCACCGATGGGTGGTTCGCCGTCCCCAGGGCCGAGCCCGGGACCGGGTCTTAGTTCCTCAAAGCAACACCCGAAGCAACATTCGCCCGGCCCGAGATCTAACCTCCGAGTCGTCATACCTACGGCACTAGGACCAAGTATTACCCCGGAAGAAGTTTCGTACGGAGAACATAATCGAACCCAGTCGACCTTGAATACGCCAGTGGTGGCACTGCAAACCCCCGGACTGTCGAATTATCCCGGCACTCTGACATCGTTCGGCGCGCAGGATTTTAGCATGGGCCCGGACATGGGTTTGAGTTCCATATCGTGGAGCGGACACCAAATATCTACAGCTCTGACACACAGTAGTAACTGTTTGCCGCATTTGGCCGTATCCAGTAGCACGCCGCCGCCGTCGTCGTCCTCACCCATACCCGTTAAAATAAAGAGTGAACCGATATCGCCTCCAAGAGAACATCATCCGCATTTGAGCACCGGCGTTCATCATTCGCACGTGCAGAGTCTTAACCTGACGCACAGCCATCATCCGAGGCCCAGTTCGGCCGGTCACATAACTCCGACTCCTGGTAGTGTCACGCCGACGAATCTGCCGTCGCCGACGGGACCGCCTAGTGGTGGTGATTACGAAAATATACAGATGCATAAGCGAGCAAGACTCACAGACTGGCCATCCTAG
Protein Sequence
MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDKVLLKYTEYNEPHESLTNKNIIEALNKKEHKNGVMSPDSPEPETEYQLTPRTEAKYSKIDEEFQMMLQRNQINGQRVSMSSSNYTQPVSVPVNISYGDSGLLQSSPQMAHTSISPRPSSSETDSVYPSGGMPEMSNGYPNSASPMGGSPSPGPSPGPGLSSSKQHPKQHSPGPRSNLRVVIPTALGPSITPEEVSYGEHNRTQSTLNTPVVALQTPGLSNYPGTLTSFGAQDFSMGPDMGLSSISWSGHQISTALTHSSNCLPHLAVSSSTPPPSSSSPIPVKIKSEPISPPREHHPHLSTGVHHSHVQSLNLTHSHHPRPSSAGHITPTPGSVTPTNLPSPTGPPSGGDYENIQMHKRARLTDWPS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00752917; iTF_00415068; iTF_00870534; iTF_01311512; iTF_01409950; iTF_00031905; iTF_00388194; iTF_00244227; iTF_00387203; iTF_01047234; iTF_00792134; iTF_00413511; iTF_00910702; iTF_00026009; iTF_01105883; iTF_00735518; iTF_00376292; iTF_01351678; iTF_00272486; iTF_01293637; iTF_00271111; iTF_00927643; iTF_00268222; iTF_01291518; iTF_00269759; iTF_00755590; iTF_00330567; iTF_00422344; iTF_00853921; iTF_00003715; iTF_01284496; iTF_01366288; iTF_01517205; iTF_01566199; iTF_00929531; iTF_00153152; iTF_00392713; iTF_01307209; iTF_01243633; iTF_01238997; iTF_00196183; iTF_00444089; iTF_01187807; iTF_00646954; iTF_01296163; iTF_00349030; iTF_01536167; iTF_00639498; iTF_01480836; iTF_01480077; iTF_00130482; iTF_01310483; iTF_01023860; iTF_01369365; iTF_00998646; iTF_00965143; iTF_00423834; iTF_00885978; iTF_00416477; iTF_00394474; iTF_01277853; iTF_01289949; iTF_00852640; iTF_01014443; iTF_00721999; iTF_00110514; iTF_01226871; iTF_01344877; iTF_01121573; iTF_00395231; iTF_00020240; iTF_00830256; iTF_00307857; iTF_00739921; iTF_00807601; iTF_00838515; iTF_01295147; iTF_00641418; iTF_00788850; iTF_00977944; iTF_00399101; iTF_01098454; iTF_01097415; iTF_01163094; iTF_00030167; iTF_00030995; iTF_00814359; iTF_00813672; iTF_00987085; iTF_00841806; iTF_00116764; iTF_01283347; iTF_01329766; iTF_00078422; iTF_00740791; iTF_01498844; iTF_01123683; iTF_00956265; iTF_00627170; iTF_00466160; iTF_01257986; iTF_00464823; iTF_01252793; iTF_01120826; iTF_00434076; iTF_00136829; iTF_00137902; iTF_00980967; iTF_00431422; iTF_01107336; iTF_01215916; iTF_01345663; iTF_00329344; iTF_00328065; iTF_00950816; iTF_00949828; iTF_01287168;
90% Identity
iTF_01296163;
80% Identity
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