Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0024 4 7.0 0.1 21 45 55 79 51 84 0.90

2 7 0.02 32 4.1 0.1 21 44 111 134 107 139 0.86

3 7 0.0013 2.2 7.9 0.2 21 43 139 161 136 167 0.89

4 7 0.00026 0.42 10.2 0.5 21 49 167 195 163 200 0.85

5 7 0.25 4.1e+02 0.6 0.2 23 43 197 217 193 222 0.86

6 7 0.00019 0.32 10.5 0.0 21 47 223 249 219 255 0.88

7 7 0.65 1.1e+03 -0.7 0.2 37 45 271 279 250 281 0.53

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0024	4	7.0	0.1	21	45	55	79	51	84	0.90
2	7	0.02	32	4.1	0.1	21	44	111	134	107	139	0.86
3	7	0.0013	2.2	7.9	0.2	21	43	139	161	136	167	0.89
4	7	0.00026	0.42	10.2	0.5	21	49	167	195	163	200	0.85
5	7	0.25	4.1e+02	0.6	0.2	23	43	197	217	193	222	0.86
6	7	0.00019	0.32	10.5	0.0	21	47	223	249	219	255	0.88
7	7	0.65	1.1e+03	-0.7	0.2	37	45	271	279	250	281	0.53

Coding Sequence: ATGAGCATGAACCATGGGAGTGAAGAGTTTGGAAATGTCACAGGTGACAGTGTTGAAgtacatgatgatgatgattcagaTTCTGTGACTGCAGTTAATTGCCACACTTCTGTTACATTGCCATTTATTTCTGCTGGTGAACGAGGTTTTATTGGACATTTTAGTGATCTTCCTCATGTTTGTTACATCTGTAATAAGGGATTTGGAAATCGAGTGAATCTTAGAAGACATTACCGAATACACACAGAATATCAACGGTATGACTGTAAGGACTGTGATAAGAGTTACAGACATTTGATAGACCTCAAACGACATGCATTGATTCACACTGGAGAACAGCCGTATTCGTGTGACGTTTGCTCAAAGAGTTTCAGCAGAATCACTCACTTGAGGGACCACGTACTGACCCATACAGGCGAGCGACCTCACGTATGCAAGATATGTTCCAAAACGTTTAGCCAGGCAAGTAATTTGCAGACACATCAGCTGACTCACACTGGAGAAAGGCCTCATGTCTGTCCTGTGTGCGGAAAGTGTTTCTCGCAGCGTGCAAATCTTCAGACCCACTCTGTGTTACACTCTGGAACACGACCATTTGTTTGTAAAATCTGTGGCAAGGGATTTCATCGGCGCCGAGACCTGCATAATCACTGTGTCACGCATACTGGGGAAAGACCACATGTGTGTCCGGTGTGTGATAAAACATTTGCATTGCTTGATAATTTGAGGAAACATTCAGATCTTCATTCAGGAAAACGCCCACATGAATGTAAGCACTGCGGAAAGACATTTGCTAAGAAATATGATCTCAACAGACATACACGTAGACATATTGAAGAGCCCAAATAA
Protein Sequence: MSMNHGSEEFGNVTGDSVEVHDDDDSDSVTAVNCHTSVTLPFISAGERGFIGHFSDLPHVCYICNKGFGNRVNLRRHYRIHTEYQRYDCKDCDKSYRHLIDLKRHALIHTGEQPYSCDVCSKSFSRITHLRDHVLTHTGERPHVCKICSKTFSQASNLQTHQLTHTGERPHVCPVCGKCFSQRANLQTHSVLHSGTRPFVCKICGKGFHRRRDLHNHCVTHTGERPHVCPVCDKTFALLDNLRKHSDLHSGKRPHECKHCGKTFAKKYDLNRHTRRHIEEPK

Sequence clustering based on sequence similarity using MMseqs2