Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 4.9 8e+03 -3.6 0.1 22 31 47 56 46 64 0.78

2 5 0.047 78 2.9 0.0 22 44 78 100 75 104 0.88

3 5 0.002 3.3 7.3 0.0 21 44 105 128 101 132 0.90

4 5 0.0007 1.1 8.8 0.1 21 45 133 157 129 162 0.88

5 5 0.0011 1.9 8.1 0.0 21 45 162 186 156 191 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	4.9	8e+03	-3.6	0.1	22	31	47	56	46	64	0.78
2	5	0.047	78	2.9	0.0	22	44	78	100	75	104	0.88
3	5	0.002	3.3	7.3	0.0	21	44	105	128	101	132	0.90
4	5	0.0007	1.1	8.8	0.1	21	45	133	157	129	162	0.88
5	5	0.0011	1.9	8.1	0.0	21	45	162	186	156	191	0.87

Coding Sequence: ATGTGGGGTGAGTTGCAGCGAATCACACCAGTCAATACATCACGAAGCCGGCCATCATTCTGGGGGGAAGTAACACATGTACAGGAGCTGTGGCAAGACTTCCTTCTTCCACTTGTCTCTACAATGGACAACGTGGCTGACAGACCGTCGCCATGTGTCATGTGCATGAAGGGCACGCAGACCACCACCAACACCACTCCACTACTTCATCATGATCATGTACATGCTACAGACAGACCATTTAGTTGTGATGTGTGTGGGAAGGGTTTTACCCAGGCAGCTCACCTGACTCGACATACACGAGTGCATACAGGTGAGAAGCCATTTTCATGTGTAGTGTGTGGGAAGAGCTTCTCTCAGTCGGGTGATCTAACAAGGCATACAAGGGTCCACACTGGTGAGAAGCCTTACTCATGTACTGTCTGTCTGAAGAGGTTCTCACAGTCAGGGGACTTGAGTCGACATACGCGGCGTGCTCATCCTGGTGAAAACCCATTCTCATGTGCGGTGTGTTTGAAAAGTTTTTCCCAGTCGGGAGGTTTGACTCGTCACACAAGAGTGCATTCTGTGACAAATAGAGTTTTGTCCACGACACATGAAGTTATGTTACAACCAAACAATTTCTCTCGTCAGACCCGTATCAATGTGGACCAGCGACAGTTTTTCCCTGATATCAACAAAGAGTTTTCTCACCTCCCGAACTTACCCTGA
Protein Sequence: MWGELQRITPVNTSRSRPSFWGEVTHVQELWQDFLLPLVSTMDNVADRPSPCVMCMKGTQTTTNTTPLLHHDHVHATDRPFSCDVCGKGFTQAAHLTRHTRVHTGEKPFSCVVCGKSFSQSGDLTRHTRVHTGEKPYSCTVCLKRFSQSGDLSRHTRRAHPGENPFSCAVCLKSFSQSGGLTRHTRVHSVTNRVLSTTHEVMLQPNNFSRQTRINVDQRQFFPDINKEFSHLPNLP

Sequence clustering based on sequence similarity using MMseqs2