Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.36 1e+04 -1.7 0.0 24 44 7 27 5 36 0.82

2 10 0.14 3.9e+03 -0.3 0.1 21 47 32 58 25 63 0.77

3 10 0.0036 1e+02 4.7 0.0 21 45 60 84 57 88 0.90

4 10 0.0035 1e+02 4.8 0.1 23 52 90 119 84 121 0.82

5 10 0.045 1.3e+03 1.2 0.0 21 46 116 141 113 147 0.81

6 10 0.00059 17 7.2 0.1 21 46 144 169 130 173 0.87

7 10 0.067 1.9e+03 0.7 0.0 25 45 204 224 190 228 0.85

8 10 0.00054 15 7.4 0.0 21 47 228 254 225 260 0.86

9 10 0.0074 2.1e+02 3.7 0.0 21 48 256 283 252 287 0.85

10 10 0.00036 10 7.9 0.2 22 45 285 308 280 313 0.88

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.36	1e+04	-1.7	0.0	24	44	7	27	5	36	0.82
2	10	0.14	3.9e+03	-0.3	0.1	21	47	32	58	25	63	0.77
3	10	0.0036	1e+02	4.7	0.0	21	45	60	84	57	88	0.90
4	10	0.0035	1e+02	4.8	0.1	23	52	90	119	84	121	0.82
5	10	0.045	1.3e+03	1.2	0.0	21	46	116	141	113	147	0.81
6	10	0.00059	17	7.2	0.1	21	46	144	169	130	173	0.87
7	10	0.067	1.9e+03	0.7	0.0	25	45	204	224	190	228	0.85
8	10	0.00054	15	7.4	0.0	21	47	228	254	225	260	0.86
9	10	0.0074	2.1e+02	3.7	0.0	21	48	256	283	252	287	0.85
10	10	0.00036	10	7.9	0.2	22	45	285	308	280	313	0.88

Coding Sequence: ATGTTGCTAAACGGCCGACCTTACAAGTGCAAGGAATGTGGCACGGCATTCTGCACGTCATCGAACTTGTCGCAGCACAAGAAGACCCACTCCGACGAGAGGCCTTTCGAGTGTGTCGAGTGCAGCGTGTCCTTCAGTAGAGTGTCCCACCTGTCTCGGCACATGGTCATCCACACCGGAGAGAAACCGTTTCTCTGCACCATGTGCGACACGTCCTTCAGCAGGTCCTACAACCTGGTGCAGCACATGAGGGTACACAGCGACGAGAAGCTCTACTCGTGTATCGCTTGTGACAAAACGTTCAGGAACTCCAACAACCTGACCTACCACATGCGGGTGCACACCGGTGAGAAACCGTACGTCTGCAAGGTCTGCGAAAAGTCATTCTCCCAGATAGGCAGCTTAAAGTACCACACCAGGATCCACACGGGGGAGAAGCCCTACGAGTGTGCGGAATGTGGCATGACTTTCAGCAGGTCGTCCAACCTGACCCGCCACATGAATATCCACACCAGGACGAACCTGTACGACTGTCTGGAGTGTGACACGTCGTACGTCACCTCCGCCGGGCTGGAGCGTCACACGAAGACCCACACCGAAGGGAAACTCTACACCTGCGTCGTGTGTGACAAAGCGTTCAAGAACTCTAACCACCTCGCAGACCACGTTAGGATACACACAGGTGAGAAGCCTTACACCTGTGTGTTGTGTCAGAAATCCTTCTCCCAGTTGGGCAACTTGAAGAACCACACGGCCATCCACACGGGGGAAAAACCCTTCCAGTGCGTGGAGTGCGGGACGTCGTTCGGCAGGGCCTCGAACTTGACCAGACACATGAGAGTTCACACCGGGGATAAACCGTTCTCCTGTGCAGTGTGTCAGACCGTGTTTACTGAGAGATCCAGTTTGAACAGACACTTGAAAAGGCACTCAAAAGAGGAGTTTCCTTGTGACTAG
Protein Sequence: MLLNGRPYKCKECGTAFCTSSNLSQHKKTHSDERPFECVECSVSFSRVSHLSRHMVIHTGEKPFLCTMCDTSFSRSYNLVQHMRVHSDEKLYSCIACDKTFRNSNNLTYHMRVHTGEKPYVCKVCEKSFSQIGSLKYHTRIHTGEKPYECAECGMTFSRSSNLTRHMNIHTRTNLYDCLECDTSYVTSAGLERHTKTHTEGKLYTCVVCDKAFKNSNHLADHVRIHTGEKPYTCVLCQKSFSQLGNLKNHTAIHTGEKPFQCVECGTSFGRASNLTRHMRVHTGDKPFSCAVCQTVFTERSSLNRHLKRHSKEEFPCD

Sequence clustering based on sequence similarity using MMseqs2