Zhep005275.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Zelleria hepariella
Gene Symbol
PAX2
Assembly
GCA_949319315.1
Location
OX439380.1:24326524-24376173[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 7e-72 1.5e-68 228.8 0.2 1 122 84 205 84 207 0.99
2 3 1.5e-21 3.1e-18 66.3 0.1 75 125 209 259 206 259 0.97
3 3 1.4 3.1e+03 -1.5 0.0 91 113 671 693 653 700 0.73

Sequence Information

Coding Sequence
ATGGGTCAGTTCCCGACGGTGTTTCAGACTGAAATCTACGCAATAAGTGCCTGCGCACAAGTGAATATAGATAGAAAAGTCACTGGCAAATCCATCTATATTCTAAGCGACAGCCAAGCCTCTCTCAAAGCCCTTATGGCCTGTAGGGTGGACTCCGGACTAGTCGAGGGCTGCGTCAGCGCGCTCAACAGGCTCGGCAGACGCAACAGACTCCATCTGGTGTGGGTGCCCGGACATGCAGGAATCCATGGCCATGGCGGCGTGAACCAACTGGGTGGCGTGTTTGTGAACGGTCGACCGCTGCCAGACGTGGTACGGCAACGGATAGTCGAGCTGGCGCACAGTGGAGTACGACCCTGCGACATCAGCAGACAACTGAGGGTCTCACACGGATGCGTGTCCAAGATACTGTCTAGGTACTACGAGACCGGCAGCTTCAAGGCTGGCGTGATCGGCGGCTCCAAGCCGAAGGTGGCGACCCCACCCGTAGTGGACGCCATCGCGGCCTACAAGCGGGAGAACCCCACCATGTTCGCGTGGGAGATCCGCGACCGGCTGCTGAGTGAGGGCATCTGCAGCCAGGACAATGTGCCGTCCGTCTCTAGCATCAACAGAGAGTCAGACGTGGCTCCACCTCTAGTAGTGGACGCCATCGCTGCCTACAAGCGGGAGAACCCCACCATGTTCGCGTGGGAGATCCGCGACCGGCTGCTGAGTGAGGGCATCTGCAGCCAGGACAATGTGCCGTCCGTTACTAGCATCAACAGGATCGTCCGCAACAAGGCAGCGGAGAAGGCGAAGCATGCGCACAACCAAcaacagcagcagcagcaggaGCAGGAGATCAGCTCGGCGCAAGGAAGTGTTGTCTCGGTAATCACCCACGCCGGCAACGCCCCTGGCGCGACGTCGGTCCTCTCCCCAGCCAATGAGCAGCACGTGCCCAACAGTGGCAACTACAGCATCAACGGCATCCTGGGTATCGAACAGGTCGACGGGCTGCACAACGGCAGCGCCGGCCTGAAGAGAAAACGGCACGAAGAGCAAGATGAGAACCGGGACTTCAACAGTCATTCCGAGGACGACGTGAAGCGACAAAGAAGTCATTACAACGGCGACCAAATATACTCAAACCTCTGGTCATCCTCAAAATGGACATTAAAAGACGAGTACAAGCTGCTGTCGGAGCTAGGCGGCGCGACTGCGACGGCAGCCACGGGATACTACGGAGAACTGTTTGACGCGCCCTACGAACATGCCGCGCATCCACACTACACTCCACATTCCGCAACGAACGACTCGACGGGGTCCAACGGTGGGGCGGGCGGGGAGCCGCCCTCGGCAGCCGCGAGCCCTGATGCAGCCGCCCTAGTCGTGCTACAACCTCCAGCGCCGCCCTACCCGCCCTACGCGCATTACGATGGTACGACGACACTGGCCAGTGAATACGCGTACGCGGCACCCTACTCGCAATACTCGCCCTACGGAGGACCCTACGCGTCGCATTCCACAGCCACAGGCTTGTTGACTAAGTGcaCCATCGAGGGAGTTGGCAGTTTCAAGTATCTGGGATCCACCTTGACCGCCCAGAACAAGACTGACGAGGAGATTAAGGCCAGGATACTAGCAGGAAACCGGTGCTTCTACTCGTGTAGTAAGCTACTGGGCTCGAAACTGCTCAGCAGAAGATCCAAGCTCGCCATCTATCGCACCATTATAAGACCAGTTGTGACTTACGCCTGTGAAACCTGGGCACTAACACAGAGAGACGAACAAAAACTTTCCATCTTCGAGCGCAAAGTGTTGAGGAAAATCTTTGGTCCTGTGAGAGAACCAGATGGCACATATCGCTATCGAATGAACCATGAGCTGGATGCGCTTATGGAGCGAGAAACCATCGTCAGGTTCTGTAAGTCGCAGCGTCTTAGATGGGCCGGTCACCTGGAaagaatgccagacaccagagccgcaaagATCCGGGTGCTCAAAACCAACCAAAGAAGCGAATACGGAAGGACAATTAACTCTAGCAATATCAAGATAAAATTGTTATCTACTGCTTTTTGCAGAATAGACGACCCTTTACCCACCATCACACCACAAGAGATGCGCAAGCCATACAGGAATCCAGAAGACATACACCCAAAAGAGCAAGCAAGGATGATACGCGAGAAAGAATGCCCACCTCTACCACCGAAACCACCTGAGCCACCAGATTGTCCACCCGAGATAGAAAAAGTTCCATGTAGAATGGTTCCTCCTCCGCTAGAAGAAAACGTAATAGATACCACCCCACCTTTCTGCGTACCAGCGAAAGAGCCCTGCACAAATTACCACAAGGACTTAGACCCGCCTCTGCTATCAAAACCCAGTGACAAGGATTGCCCACCTCCTAAATGGGCAAGGAAACATAAAAAGAAAGAGGATCCGTGTTGTTGA
Protein Sequence
MGQFPTVFQTEIYAISACAQVNIDRKVTGKSIYILSDSQASLKALMACRVDSGLVEGCVSALNRLGRRNRLHLVWVPGHAGIHGHGGVNQLGGVFVNGRPLPDVVRQRIVELAHSGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAGVIGGSKPKVATPPVVDAIAAYKRENPTMFAWEIRDRLLSEGICSQDNVPSVSSINRESDVAPPLVVDAIAAYKRENPTMFAWEIRDRLLSEGICSQDNVPSVTSINRIVRNKAAEKAKHAHNQQQQQQQEQEISSAQGSVVSVITHAGNAPGATSVLSPANEQHVPNSGNYSINGILGIEQVDGLHNGSAGLKRKRHEEQDENRDFNSHSEDDVKRQRSHYNGDQIYSNLWSSSKWTLKDEYKLLSELGGATATAATGYYGELFDAPYEHAAHPHYTPHSATNDSTGSNGGAGGEPPSAAASPDAAALVVLQPPAPPYPPYAHYDGTTTLASEYAYAAPYSQYSPYGGPYASHSTATGLLTKCTIEGVGSFKYLGSTLTAQNKTDEEIKARILAGNRCFYSCSKLLGSKLLSRRSKLAIYRTIIRPVVTYACETWALTQRDEQKLSIFERKVLRKIFGPVREPDGTYRYRMNHELDALMERETIVRFCKSQRLRWAGHLERMPDTRAAKIRVLKTNQRSEYGRTINSSNIKIKLLSTAFCRIDDPLPTITPQEMRKPYRNPEDIHPKEQARMIREKECPPLPPKPPEPPDCPPEIEKVPCRMVPPPLEENVIDTTPPFCVPAKEPCTNYHKDLDPPLLSKPSDKDCPPPKWARKHKKKEDPCC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-