Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 2.1e-07 0.0012 18.8 0.0 12 48 64 100 58 103 0.92

2 7 0.0035 20 5.3 0.4 21 45 104 128 98 134 0.84

3 7 0.049 2.8e+02 1.7 0.4 20 44 131 155 128 158 0.81

4 7 0.0027 16 5.7 0.6 16 45 155 184 142 187 0.85

5 7 0.0028 16 5.6 0.6 18 44 185 211 184 215 0.91

6 7 0.00078 4.5 7.4 0.1 21 44 216 239 212 247 0.87

7 7 0.0053 31 4.8 0.2 21 44 244 267 240 276 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	2.1e-07	0.0012	18.8	0.0	12	48	64	100	58	103	0.92
2	7	0.0035	20	5.3	0.4	21	45	104	128	98	134	0.84
3	7	0.049	2.8e+02	1.7	0.4	20	44	131	155	128	158	0.81
4	7	0.0027	16	5.7	0.6	16	45	155	184	142	187	0.85
5	7	0.0028	16	5.6	0.6	18	44	185	211	184	215	0.91
6	7	0.00078	4.5	7.4	0.1	21	44	216	239	212	247	0.87
7	7	0.0053	31	4.8	0.2	21	44	244	267	240	276	0.84

Coding Sequence: ATGGAGCAAGTGATAGATGTGGGTTGTGTCAAGGAGGAACACTGTGAGGCAATTTGCAATATGTTCAGGACACAAGATTGGCAATTAACGATGCGACACAGAGACTTGGGAATCGTGAAAATTGAACAGGACATGAGCATAGTCTGGCAAAGCGCTAGCACTGCCGCAGTAGACAACAAGGAAGCGCATTCAGACAAGCCGAAGAGCTTCACATCCAGTGAGAAACCATTTAAGTGTCCACATTGCACAAAGGACTTTGCCACGAGCAGCAATCTAAAGGTTCATCTCACACGCACCCACTCTGGCGACCAGGAGCGTCCATTTGAGTGCCCCACCTGCCCGAAGTCTTTTGCCACCAACGACAACCTACAGAAGCACATTCGCAGGCATTCGAATGAGCGAAACCTCAATTGCCCACACTGCCCAAAGGCTTTCGCGACCAAGGATAATCTGCAGAAACACATTCGCCGCCACTCGAGCGAGCGCAACCACAACTGTCCGCACTGTCCCAAAGCATTTGCCACCAACGACAATCTGCAAAAGCACATTCGACGTCACTCCAGCGAAAGAAATCTTCAGTGTCCGCACTGCCCCAAGGCTTTTGCGACAAACGATAATCTTCAGCGACACATACGCGGCCACACTGGAGAGCGGCCGTTCAAGTGTCCATACTGCCCCAAACCGTTCGCCCAGAACAGAGATCTTAAAGCGCACATCTTGGAGCATACTGGGGAAAAACCCTTCAAATGTCCCCATTGCCCCAAGGCGTGTGTACGTAGCGAAGGACTGAAGAAGCATATTTTGCGACTCCACAAGGACGTTGAGCCGGCAACGGTGGAGACAACGGCAGCTAAACAATGGCAAACTCCCACTGAGGTCAAGTCCTACATCAACGATGCCAACGGCAGAGTCTTCATGTACAAATACGATCTGACTAAGCAGACTCGAATGCCCACGGGCGAGGCGTAA
Protein Sequence: MEQVIDVGCVKEEHCEAICNMFRTQDWQLTMRHRDLGIVKIEQDMSIVWQSASTAAVDNKEAHSDKPKSFTSSEKPFKCPHCTKDFATSSNLKVHLTRTHSGDQERPFECPTCPKSFATNDNLQKHIRRHSNERNLNCPHCPKAFATKDNLQKHIRRHSSERNHNCPHCPKAFATNDNLQKHIRRHSSERNLQCPHCPKAFATNDNLQRHIRGHTGERPFKCPYCPKPFAQNRDLKAHILEHTGEKPFKCPHCPKACVRSEGLKKHILRLHKDVEPATVETTAAKQWQTPTEVKSYINDANGRVFMYKYDLTKQTRMPTGEA

Sequence clustering based on sequence similarity using MMseqs2