Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 2.3e-06 0.019 14.9 0.1 12 48 64 100 58 102 0.91

2 7 0.0022 18 5.4 0.4 21 45 104 128 98 135 0.83

3 7 0.024 1.9e+02 2.1 0.5 18 45 129 156 125 159 0.81

4 7 0.0018 14 5.7 0.6 16 45 155 184 142 187 0.85

5 7 0.0017 14 5.7 0.6 18 44 185 211 183 215 0.91

6 7 0.00068 5.4 7.1 0.1 21 44 216 239 212 243 0.89

7 7 0.0033 27 4.8 0.2 21 45 244 268 241 273 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	2.3e-06	0.019	14.9	0.1	12	48	64	100	58	102	0.91
2	7	0.0022	18	5.4	0.4	21	45	104	128	98	135	0.83
3	7	0.024	1.9e+02	2.1	0.5	18	45	129	156	125	159	0.81
4	7	0.0018	14	5.7	0.6	16	45	155	184	142	187	0.85
5	7	0.0017	14	5.7	0.6	18	44	185	211	183	215	0.91
6	7	0.00068	5.4	7.1	0.1	21	44	216	239	212	243	0.89
7	7	0.0033	27	4.8	0.2	21	45	244	268	241	273	0.85

Coding Sequence: ATGGAGCAAGTGATAGATGTGGGTTGTGTCAAGGAGGAGCACTGTGAGGCAATTTGCAATATGTTCAGGACACAGGATTGGCAATTAACGATGCGACACAGAGACTTGGGAATCGTGAAAATCGAACAGGACATGAGCATAGTCTGGCAAAGCGCTAGCACTGCCGCAGTGGTCAACAAGGAAGCAAATTCAGACAAGCAAAAGAGCGTCACATCCAGCGAGAAACCATTTAAGTGTCCACACTGCACAAAGGACTTTGCCACCAGCAGCAATCTAAAGGTTCATCTCACGCGCACCCACTCCGGCGACCAGGAGCGTCCATTTGAGTGCCCCACCTGCCCGAAGTCATTTGCCACCAACGACAACCTTCAGAAGCATATTCGCAGGCATTCGAATGAGCGAAACCTCAATTGCCCACACTGCCCAAAGGCTTTCGCCACCAAGGATAATCTGCAGAAACACATTCGCCGCCACTCAAGCGAGCGCAACCACAACTGTCCGCACTGTCCCAAGGCATTTGCCACCAACGACAATCTGCAGAAGCACATCCGACGACACTCCAGCGAAAGGAATCTTCAGTGTCCACACTGCCCCAAAGCTTTTGCAACAAACGATAATCTCCAGCGACACATACGCGGCCACACTGGCGAGCGGCCCTTTAAGTGTCCGTACTGCCCCAAACCGTTTGCCCAAAACAGAGATCTTAAAGCGCACATCTTGGAGCATACTGGGGAAAAACCCTTCAAATGTCCCCACTGTCCCAAGGCGTGTGTGCGCAGCGAAGGTCTAAAGAAGCATATTTCGCGACTCCACAAAGACATAGAGCCACCAACGGTGGAGACAACGGCAACTAAACAATGGCAGACTCCAACTGAGGTCAAGTCCTACATCAACGATGCCAACGGCAGAGTCTTCATGTACAAATACGATCTGACTAAACAGACTCGAATGCCCACGGGCGAGGCGTAA
Protein Sequence: MEQVIDVGCVKEEHCEAICNMFRTQDWQLTMRHRDLGIVKIEQDMSIVWQSASTAAVVNKEANSDKQKSVTSSEKPFKCPHCTKDFATSSNLKVHLTRTHSGDQERPFECPTCPKSFATNDNLQKHIRRHSNERNLNCPHCPKAFATKDNLQKHIRRHSSERNHNCPHCPKAFATNDNLQKHIRRHSSERNLQCPHCPKAFATNDNLQRHIRGHTGERPFKCPYCPKPFAQNRDLKAHILEHTGEKPFKCPHCPKACVRSEGLKKHISRLHKDIEPPTVETTATKQWQTPTEVKSYINDANGRVFMYKYDLTKQTRMPTGEA

Sequence clustering based on sequence similarity using MMseqs2