Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 1.9e-05 0.15 12.0 0.1 13 48 65 100 58 103 0.90

2 7 0.0027 22 5.1 0.8 21 45 104 128 98 139 0.82

3 7 0.022 1.8e+02 2.2 0.6 18 45 129 156 125 160 0.81

4 7 0.0017 14 5.8 0.5 16 45 155 184 142 187 0.85

5 7 0.0018 14 5.7 0.6 18 44 185 211 183 215 0.91

6 7 0.00068 5.5 7.1 0.1 21 44 216 239 212 243 0.89

7 7 0.0032 26 4.9 0.2 21 45 244 268 241 274 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	1.9e-05	0.15	12.0	0.1	13	48	65	100	58	103	0.90
2	7	0.0027	22	5.1	0.8	21	45	104	128	98	139	0.82
3	7	0.022	1.8e+02	2.2	0.6	18	45	129	156	125	160	0.81
4	7	0.0017	14	5.8	0.5	16	45	155	184	142	187	0.85
5	7	0.0018	14	5.7	0.6	18	44	185	211	183	215	0.91
6	7	0.00068	5.5	7.1	0.1	21	44	216	239	212	243	0.89
7	7	0.0032	26	4.9	0.2	21	45	244	268	241	274	0.85

Coding Sequence: ATGGATCAAGTGATAGATGTGGGTTGTGTCAAGGAGGAGCACTGTGAGGCGATTTGCAATATGTTCAGGACACAGGATTGGCAATTAACGATGAGACACAGGGATTTGGGAATCGTGAAAATCGAACAGGACATGAGCATAGTCTGGCAAAGCGCTAACTCTGCCGCAGTGGTCAACAAGGATGCACACTCAGACAAGCAAAAGAGCATCACATCCAGTGAGAAACCATTTAAATGTCCACACTGCACAAAGGACTTTGCCACTAACAGCAATCTAAAGGTTCATCTCACACGCACACACTCAGGCGACCAGGAGCGTCCATTTGAGTGTCCCACCTGCCCGAAGTCATTTGCCACCAACGACAATCTTCAGAAGCACATTCGCAGGCATTCGAATGAGCGAAACCTCAATTGCCCACACTGCCCAAAGGCTTTCGCCACCAAGGATAATCTGCAGAAACACATTCGGCGCCACTCAAGTGAGCGCAACCACAACTGTCCGCACTGTCCCAAGGCGTTTGCCACCAACGACAATCTGCAGAAGCATATCCGACGACACTCCAGCGAAAGGAATCTTCAGTGTCCACACTGCCCCAAGGCTTTTGCGACAAACGATAATCTCCAGCGACACATTCGTGGCCACACCGGCGAGCGGCCTTTTAAGTGTCCTTACTGCCCCAAACCGTTTGCCCAAAACAGAGATCTTAAAGCGCACATCTTGGAGCATACTGGGGAAAAACCCTTCAAATGTCCCCACTGTCCCAAGGCCTGTGTGCGAAGCGAAGGTTTGAAAAAGCATATTTCGCGACTCCACAAGGACGTAGAGCCAGCAACGGTGGACACAACGGCAACTAAACAATGGCAGACACCAACTGAGGTTAAGTCCTACATCAACGATGCAAACGGCAGAGTCTTTATGTACAAATACGACCTGACAAAACAGACTCGAATGCCCACGGGCGAGGCGTAA
Protein Sequence: MDQVIDVGCVKEEHCEAICNMFRTQDWQLTMRHRDLGIVKIEQDMSIVWQSANSAAVVNKDAHSDKQKSITSSEKPFKCPHCTKDFATNSNLKVHLTRTHSGDQERPFECPTCPKSFATNDNLQKHIRRHSNERNLNCPHCPKAFATKDNLQKHIRRHSSERNHNCPHCPKAFATNDNLQKHIRRHSSERNLQCPHCPKAFATNDNLQRHIRGHTGERPFKCPYCPKPFAQNRDLKAHILEHTGEKPFKCPHCPKACVRSEGLKKHISRLHKDVEPATVDTTATKQWQTPTEVKSYINDANGRVFMYKYDLTKQTRMPTGEA

Sequence clustering based on sequence similarity using MMseqs2