Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 5.2e-07 0.0042 17.0 0.1 11 48 63 100 55 103 0.91

2 7 0.0024 19 5.3 0.8 20 45 103 128 97 139 0.82

3 7 0.028 2.3e+02 1.9 0.5 19 45 130 156 127 159 0.81

4 7 0.0018 15 5.7 0.8 16 45 155 184 142 188 0.85

5 7 0.0018 15 5.7 0.6 18 44 185 211 183 215 0.91

6 7 0.00064 5.2 7.1 0.1 21 44 216 239 212 244 0.89

7 7 0.0031 26 4.9 0.2 21 45 244 268 240 273 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	5.2e-07	0.0042	17.0	0.1	11	48	63	100	55	103	0.91
2	7	0.0024	19	5.3	0.8	20	45	103	128	97	139	0.82
3	7	0.028	2.3e+02	1.9	0.5	19	45	130	156	127	159	0.81
4	7	0.0018	15	5.7	0.8	16	45	155	184	142	188	0.85
5	7	0.0018	15	5.7	0.6	18	44	185	211	183	215	0.91
6	7	0.00064	5.2	7.1	0.1	21	44	216	239	212	244	0.89
7	7	0.0031	26	4.9	0.2	21	45	244	268	240	273	0.85

Coding Sequence: ATGGAGCAAGTGATAGATGTGGGTTGTGTCAAGGAGGAGCACTGTGAGGCAATTTGCAATATGTTCAGGACACAGGATTGGCAATTAACGATGCGACACAGAGACTTGGGAATCGTGAAAATCGAACAGGACATGAGCATAGTTTGGCAAAGCGCTAGCACTGCCGCAGTGGTCAACAAGGAAGCACATACAGACAAGCAAAAGAGCGTCACATCCAGCGAGAAACCATTTAAGTGTCCACACTGCACAAAGGACTTTGCCACTAGCAGCAATCTAAAAGTCCATCTCACGCGCACCCACTCCGGCGACCAGGAGCGTCCATTTGAGTGCCCCACCTGCCCGAAGTCATTTGCCACCAACGACAACCTTCAGAAGCACATTCGCAGGCATTCGAATGAGCGAAACCTCAATTGCCCACACTGCCCAAAGGCTTTCGCCACCAAGGATAATCTGCAGAAACACATTCGCCGCCACTCAAGCGAGCGCAACCACAACTGTCCGCACTGTCCCAAGGCATTTGCCACCAACGACAATCTGCAGAAGCACATCCGACGACACTCCAGCGAAAGGAATCTTCAGTGTCCACACTGCCCCAAGGCTTTTGCGACAAACGATAATCTCCAGCGACACATACGCGGCCACACTGGCGAGCGGCCCTTTAAGTGTCCGTACTGCCCTAAACCGTTTGCCCAAAACAGAGATCTTAAAGCGCACATCTTGGAGCATACTGGGGAAAAACCCTTCAAATGTCCCCACTGTCCCAAGGCGTGTGTGCGCAGCGAAGGTCTGAAGAAGCATATTTCGCGACTCCACAAAGACATAGAGCCACCAACGGTGGAGACAACGGCAACTAAACAATGGCAGACTCCAACTGAGGTCAAGTCCTACATCAACGATGCCAACGGCAGAGTCTTCATGTACAAATACGATCTGACTAAACAGACTCGAATGCCCACGGGCGAGGCGTAA
Protein Sequence: MEQVIDVGCVKEEHCEAICNMFRTQDWQLTMRHRDLGIVKIEQDMSIVWQSASTAAVVNKEAHTDKQKSVTSSEKPFKCPHCTKDFATSSNLKVHLTRTHSGDQERPFECPTCPKSFATNDNLQKHIRRHSNERNLNCPHCPKAFATKDNLQKHIRRHSSERNHNCPHCPKAFATNDNLQKHIRRHSSERNLQCPHCPKAFATNDNLQRHIRGHTGERPFKCPYCPKPFAQNRDLKAHILEHTGEKPFKCPHCPKACVRSEGLKKHISRLHKDIEPPTVETTATKQWQTPTEVKSYINDANGRVFMYKYDLTKQTRMPTGEA

Sequence clustering based on sequence similarity using MMseqs2