Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.01 34 4.7 0.0 9 38 11 45 6 49 0.81

2 6 0.0086 28 4.9 0.0 9 38 57 91 50 95 0.82

3 6 0.0099 33 4.7 0.0 9 38 103 137 96 141 0.81

4 6 0.0086 28 4.9 0.0 9 38 149 183 142 187 0.82

5 6 0.017 55 4.0 0.0 9 38 195 229 188 233 0.76

6 6 0.094 3.1e+02 1.6 0.1 9 26 241 258 236 272 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.01	34	4.7	0.0	9	38	11	45	6	49	0.81
2	6	0.0086	28	4.9	0.0	9	38	57	91	50	95	0.82
3	6	0.0099	33	4.7	0.0	9	38	103	137	96	141	0.81
4	6	0.0086	28	4.9	0.0	9	38	149	183	142	187	0.82
5	6	0.017	55	4.0	0.0	9	38	195	229	188	233	0.76
6	6	0.094	3.1e+02	1.6	0.1	9	26	241	258	236	272	0.84

Coding Sequence: ATGGAATGCAGCGGCAGCCAGCTAACGGAGCGGCGCCTTGCAGCGGGCTGGCGCAGTAGCGTCTTACAGCGCGTCGCCGGCGGGCTGACACAGGCGACTTGCAGCGTGCAGGCTGCGGACTGGTACTTCGCGCCGGCGATGGCATGCAGCAGCGGCGAGCTAACGGAGCGACGCCTTGCAGCGGGCTGGCGCAGTAGCGTCTTACAGCGCGTCGCCGGCGGGCTGACACAGGCGACTTGCAGCGTGCAGGCTGCGGGCTGGTACTTCGCGCCGGCGATGGCATGCAGCAGCGGCGAGCTAACGGAGCGACGCCTTGCAGCGGGCTGGCGCAGTAGCGTCTTACAGCGCGTCGCCGGCGGGCTGACACAGGCGACTTGCAGCGTGCAGGCTGCGGACTGGTACTTCGCGCCGGCGATGGCATGCAGCAGCGGCGAGCTAACAGAGCGACGCCTTGCAGCGGGCTGGCGCAGTAGCGTCTTACAGCGCGTCGCCGGCGGGCTGACACAGGCGACTTGCAGCGTGCAGGCTGCGGGCTGGTACTTCGCGCCGGCGATGGCATGCAGCAGCGGCGAGCTAACGGAGCGACGCCTTGCAGCGGGCTGGCGCAGTAGCGTCTTACAGCGCGTCGCCGGCGGGCTGACACAGGCGACTTGCAGCGTGCAGGCTGCGCACTGGTACTCCGCGCCGGCGATGGCATGCAGCAGCGGCGAGCTAACGGAGCGACGCCTTGCAGCGGGCTGGCGGAGTAGCGTCTTGCGGCGCGTCGACGGCGGGCTAGCACAGAGGCGTCGAGCTGGCGGAGCGGCGCCTTGCTGCGCGCTGTCGGCGGAGCAGTGGTGTCTCGCAGCGTATGAGGTCGGAGGCACGTTGCTGCGTCCTGAATGCGGACTGGCATCCTGCAGCGCACCGGCGGTGAAGCAGTGA
Protein Sequence: MECSGSQLTERRLAAGWRSSVLQRVAGGLTQATCSVQAADWYFAPAMACSSGELTERRLAAGWRSSVLQRVAGGLTQATCSVQAAGWYFAPAMACSSGELTERRLAAGWRSSVLQRVAGGLTQATCSVQAADWYFAPAMACSSGELTERRLAAGWRSSVLQRVAGGLTQATCSVQAAGWYFAPAMACSSGELTERRLAAGWRSSVLQRVAGGLTQATCSVQAAHWYSAPAMACSSGELTERRLAAGWRSSVLRRVDGGLAQRRRAGGAAPCCALSAEQWCLAAYEVGGTLLRPECGLASCSAPAVKQ

Sequence clustering based on sequence similarity using MMseqs2