Xcam019264.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Xiphydria camelus
Gene Symbol
bs
Assembly
GCA_963678675.1
Location
OY783199.1:23232412-23236574[-]

Transcription Factor Domain

TF Family
SRF
Domain
SRF domain
PFAM
PF00319
TF Group
Helix-turn-helix
Description
Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 7.1e-25 9e-21 73.6 0.1 1 48 135 182 135 182 0.98

Sequence Information

Coding Sequence
ATGGACAACCCTAGCGGCGGAAGGGACAGTCGGTACGCGGGTCTCGGCTACGGCATGGGGTTGATGGGCAGCGACGCTGGGTCGGAGATGTACGGCCGACCGTCCACTTCTCAACTCGCAGCTTCTCAGATAGGCCGCGGCGGCGCCACCATGATGGCGAGCACCGGGGGCGCCGCGACGCCTGGCGTCGCCGTTCAGCGGGGCATGAAACGCTCGTCCTCCGACGTCTGCTTTGACGACGCAAACACGCGACAGGGCATGCCGCCCGGCCAGGGAATGAGGATGCCCGGTGACTGTGTGCCCGACAATCTCGAGGAGTCCTTCACGAATTTGGGCCAGCCGAAGAAGTCGCCGCCTTCGAACGGGAAGAAGACGAAAGGAAGGGTTAAGATTAAGATGGAGTACATTGACAACAAACTCCGGAGGTACACAACTTTCTCGAAGAGGAAGACCGGGATAATGAAGAAGGCCTACGAGCTATCCACGCTGACGGGTACTCAGGTGATGCTGCTGGTGGCCAGTGAAACCGGTCACGTGTACACCTTCGCGACGCGCAAGCTCCAGCCGATGATAACGAGCGAGGCGGGCAAGGCGCTGATCCAGACCTGTCTGAATAGCCCGGACCCGCCGCCGTCCGGCTCGTCGGGGGACCAGCGCATGTCGGCGACGGGCTTCGAGGAAACCGAGCTCACGTACAACATCGCGGACGACGAGCAGAAAGTAAGGCAACTGGTGTATGGCTCGCCGCACGGGGGCGCTCTGCACGGCGGCTACCCGACGGCCGGGGCGCCGCCGGGCGCTCAGCACGCGCCACCCCCACACGCGCAGCATGCGCAGCACGCGCATCTAATCGCACATGCGCATGCGGGATCGCCGAGCTCGCACTTAGTGCCGTGCTCGAGCCCCGGGCCTATGTTGGCGGGAGGGCCTTATCAGCAGTCGTGTCCCTCACCCCTTCCCCCGCCTCACGCGACTTACCACCCGCACATGTCGCACTCGCACCCTCAGCGGTAG
Protein Sequence
MDNPSGGRDSRYAGLGYGMGLMGSDAGSEMYGRPSTSQLAASQIGRGGATMMASTGGAATPGVAVQRGMKRSSSDVCFDDANTRQGMPPGQGMRMPGDCVPDNLEESFTNLGQPKKSPPSNGKKTKGRVKIKMEYIDNKLRRYTTFSKRKTGIMKKAYELSTLTGTQVMLLVASETGHVYTFATRKLQPMITSEAGKALIQTCLNSPDPPPSGSSGDQRMSATGFEETELTYNIADDEQKVRQLVYGSPHGGALHGGYPTAGAPPGAQHAPPPHAQHAQHAHLIAHAHAGSPSSHLVPCSSPGPMLAGGPYQQSCPSPLPPPHATYHPHMSHSHPQR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01198625; iTF_00295203; iTF_00295971; iTF_01199364; iTF_00291493; iTF_00297509; iTF_00252774; iTF_00254281; iTF_01395082; iTF_00293677; iTF_01475406; iTF_00253522; iTF_01473138; iTF_01474642; iTF_01130772; iTF_01473878; iTF_00298266; iTF_00252027; iTF_00770331; iTF_00255038; iTF_00296735; iTF_00294432; iTF_01100545; iTF_01299138; iTF_01306412; iTF_00266415; iTF_00829459; iTF_01057604; iTF_01056775; iTF_01055947; iTF_00343136; iTF_01379172; iTF_01393477; iTF_01389386; iTF_01394256; iTF_01392724; iTF_01391063; iTF_01391927; iTF_01390171; iTF_00460478; iTF_00439430; iTF_01103511; iTF_00263418; iTF_00262618; iTF_01120167; iTF_00316746; iTF_00131244; iTF_01560395; iTF_00996996; iTF_01001220; iTF_00996303; iTF_01002038; iTF_01000508; iTF_00047921; iTF_00378713; iTF_00380252; iTF_00451898; iTF_00379579; iTF_01273740; iTF_00438713; iTF_01273054; iTF_01004206; iTF_01006022; iTF_00633587; iTF_00391249; iTF_01005043; iTF_01207316; iTF_00652674; iTF_00397251; iTF_00721219; iTF_00841031; iTF_00058664; iTF_00905384; iTF_00057907; iTF_00398039; iTF_00059417; iTF_01364605; iTF_00414262; iTF_01497372; iTF_00459712; iTF_00050904; iTF_00629061; iTF_01129305; iTF_00046106; iTF_00046930; iTF_00937980; iTF_01102013; iTF_01102753; iTF_01101285; iTF_00798535; iTF_00168383;
90% Identity
iTF_01198625; iTF_00295203; iTF_00295971; iTF_01199364; iTF_00291493; iTF_00297509; iTF_00252774; iTF_00254281; iTF_01395082; iTF_00293677; iTF_01475406; iTF_00253522; iTF_01473138; iTF_01474642; iTF_01130772; iTF_01473878; iTF_00298266; iTF_00252027; iTF_00770331; iTF_00255038; iTF_00296735; iTF_00294432;
80% Identity
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