Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.32 5.1e+02 2.5 0.2 22 44 7 29 4 36 0.86

2 8 0.26 4.2e+02 2.7 0.1 25 44 38 57 30 67 0.87

3 8 3.6 5.7e+03 -0.9 0.1 25 44 66 85 58 91 0.82

4 8 0.076 1.2e+02 4.4 0.1 9 44 77 113 71 117 0.74

5 8 0.0062 9.9 7.9 0.0 21 44 118 141 115 145 0.92

6 8 2.4e-05 0.039 15.6 0.2 21 45 146 170 143 176 0.90

7 8 0.27 4.3e+02 2.7 0.1 26 44 234 252 228 260 0.84

8 8 0.2 3.2e+02 3.1 0.2 23 47 259 283 255 288 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.32	5.1e+02	2.5	0.2	22	44	7	29	4	36	0.86
2	8	0.26	4.2e+02	2.7	0.1	25	44	38	57	30	67	0.87
3	8	3.6	5.7e+03	-0.9	0.1	25	44	66	85	58	91	0.82
4	8	0.076	1.2e+02	4.4	0.1	9	44	77	113	71	117	0.74
5	8	0.0062	9.9	7.9	0.0	21	44	118	141	115	145	0.92
6	8	2.4e-05	0.039	15.6	0.2	21	45	146	170	143	176	0.90
7	8	0.27	4.3e+02	2.7	0.1	26	44	234	252	228	260	0.84
8	8	0.2	3.2e+02	3.1	0.2	23	47	259	283	255	288	0.86

Coding Sequence: ATGATCTGTCATACAGATGAGAAGGCCTACGAATGTGATATTTGTAAGAAAAGGTTCTGCGAGTTACGAAACCTTAAGAGTCATATGGCATGTCACGTGGAGGAGAAGCGCTACGAATGCAAGACGTGTAAAAAAGTTTTCCGCTTGTGCGGAAATCTAAAAACACATATGATGTGTCACACAGAGGAGAAGTtgtacaagtgtgaaatttgtgGAAAAGAATTCCATCAGCCCCAGGGACTAAAGAGTCATATGAGGTGCCACATGGAGGAAAAGCAGTACGAATGTGAGATTTGCAAAAAAGTTTTCCGTTTCTACCAAAGTCTAAAGGGCCATATGCTTTGCCACACAGATGAAAAGCCCTTCATATGTGAAACTTGTAAAAAAGGGTTCCGTGATTCCCAACAACTAAAACGTCATATGATCTGTCACACAGATGAGAAGCCctacaaatgcgaaatttgtgAAAAAGCATTTCGACAAACCCGTTATCTAAGGAAGCATATGACATACCATACGAACAGTAAGCTTTACCAGTGTGAAAAATGTAAACGAACGTACCATAAGCAAAATAGCCTAAAAGCCCATGTGTGTGACGTAGACCAAGAGCTttataaatgtgaaatttgtaaaaaagaGTTCTGTTCGTTCCCAAAACTAAAGCACCATATAAAGGGCCACATAGAAGAGGGACGCCATAAATGCGATATTTGTAAAAAAGTGTTTCGTTATCCTTCAGCTTTAAAATCTCACATGCTTTGCCACACAGACCGTAAACCACATCAGTGCCACATATGCATGAAGAGTTTTCGAAAGAAGGCCCAACTCAGCAACCATTTCAGTAAGTATCATAAAACTGAAGAAGTTGTCAATGGTGATATAGGTGGAAAACCAGATACATCAAGACCTGATTTGGCTGCTGGATTGAACGAAGCAGTTAATGTTCAGGAAATTCAATTTGTAGTTGTAAAGAAAGAATTAGAATATTCTGGAAACGGTTCTCTCATTAATGAGGGTGGAGAGGAAATGTATGGGTAA
Protein Sequence: MICHTDEKAYECDICKKRFCELRNLKSHMACHVEEKRYECKTCKKVFRLCGNLKTHMMCHTEEKLYKCEICGKEFHQPQGLKSHMRCHMEEKQYECEICKKVFRFYQSLKGHMLCHTDEKPFICETCKKGFRDSQQLKRHMICHTDEKPYKCEICEKAFRQTRYLRKHMTYHTNSKLYQCEKCKRTYHKQNSLKAHVCDVDQELYKCEICKKEFCSFPKLKHHIKGHIEEGRHKCDICKKVFRYPSALKSHMLCHTDRKPHQCHICMKSFRKKAQLSNHFSKYHKTEEVVNGDIGGKPDTSRPDLAAGLNEAVNVQEIQFVVVKKELEYSGNGSLINEGGEEMYG

Sequence clustering based on sequence similarity using MMseqs2