Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.17 2.8e+02 3.3 0.0 21 44 99 122 95 127 0.87

2 8 1.6 2.6e+03 0.2 0.0 24 45 129 150 109 157 0.78

3 8 0.00035 0.57 11.9 0.1 21 45 154 178 151 186 0.88

4 8 0.13 2.1e+02 3.7 0.1 24 44 213 233 209 237 0.89

5 8 0.03 48 5.7 0.1 21 44 238 261 234 265 0.91

6 8 0.0033 5.3 8.8 0.2 21 44 266 289 262 293 0.91

7 8 0.0029 4.6 9.0 1.4 21 44 294 317 291 321 0.92

8 8 0.0026 4.2 9.1 0.7 21 53 322 353 319 354 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.17	2.8e+02	3.3	0.0	21	44	99	122	95	127	0.87
2	8	1.6	2.6e+03	0.2	0.0	24	45	129	150	109	157	0.78
3	8	0.00035	0.57	11.9	0.1	21	45	154	178	151	186	0.88
4	8	0.13	2.1e+02	3.7	0.1	24	44	213	233	209	237	0.89
5	8	0.03	48	5.7	0.1	21	44	238	261	234	265	0.91
6	8	0.0033	5.3	8.8	0.2	21	44	266	289	262	293	0.91
7	8	0.0029	4.6	9.0	1.4	21	44	294	317	291	321	0.92
8	8	0.0026	4.2	9.1	0.7	21	53	322	353	319	354	0.87

Coding Sequence: ATGTCTGTTTGCGACACAGTTAAAACTGAATTAAGAGATGATTGGAGTGCAATagaaatggaagaaaaatttattatagaTGAAGGGGAGCGAATAAAAGAATCGGAGATCGAGTTAGATTTTTGTGTAGGGGATAAAAAGGCAATCAATTTTCCTAACAAAGAAGCTGATGAAATTAGAAACGAACATCTTGAAGAAAAAGGagaaaacaatataaatatattCAAATGTCCCGATTGCCTGAAAGTCTACAACAGCGTCGATGGGTTTATGGCCCATTGGAAAATGCATGCTAGCAAAAAACCGCACATATGCGTTATATGTAAAGAAGTATTCCATAAGCCGCTATTTCTAAAGAATCACATGACGTGTCATGCAGACGACAAGTACAAATGCAAAGTATGTAAAAGGGTGTTCAACCATCTTTCACATGTGAAGCGTCACATGATGTGTCATACAGGAGAGAAGCCCTTTCAATGTGAAGTGTGTAAAAAAGTGTTCCGTCAGCACTCGAATCTGACGAGTCACATGAGGGgccacacaggtgaaaagcccTACAAATGCGAAAAATGTGGAAAAGCGTTCCGTACAAAAGTAAGTCTAACTGATCACATGATTTTCCACACAGATGGGATTCCaaacaaatgtgaaatatgtaaaaaagtgTTTCGTTATCAAACATACCTAAAGTACCACATGATGTGCCACACGGGAGAGAAGCCCTACAAATGTGAACTGTGTGAAAAGATGTTCCGCCAGCGTGGACACCTAAAGCATCACATGATGTGCCATACGGGTGAAAGGCCTCATACATGCAACGTATGTAAAAAATCGTTTCGCGAGAAACGCCATCTAACTGAACATATGGTTTGCCACACGAATGAGCGGCCCTACGTGTGTGAAATATGCACAAAAGCATTCCGTTATCCACAACATCTTAGACGTCATATAATGTGCCACACAGACGAGAAGCCCTATGCATGCGAACTATGTAAAAAGGCGTTCCGCCAGCAGGCACACCTGAAGCACCATTTGTTATGCCACACAACTAAAGTTGGGACATCTCACAGTATTTTAGAAGTAAACTCTTAA
Protein Sequence: MSVCDTVKTELRDDWSAIEMEEKFIIDEGERIKESEIELDFCVGDKKAINFPNKEADEIRNEHLEEKGENNINIFKCPDCLKVYNSVDGFMAHWKMHASKKPHICVICKEVFHKPLFLKNHMTCHADDKYKCKVCKRVFNHLSHVKRHMMCHTGEKPFQCEVCKKVFRQHSNLTSHMRGHTGEKPYKCEKCGKAFRTKVSLTDHMIFHTDGIPNKCEICKKVFRYQTYLKYHMMCHTGEKPYKCELCEKMFRQRGHLKHHMMCHTGERPHTCNVCKKSFREKRHLTEHMVCHTNERPYVCEICTKAFRYPQHLRRHIMCHTDEKPYACELCKKAFRQQAHLKHHLLCHTTKVGTSHSILEVNS

Sequence clustering based on sequence similarity using MMseqs2