Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 6.8 1.1e+04 -1.8 0.1 25 36 105 116 88 132 0.63

2 8 0.33 5.3e+02 2.4 0.1 23 45 131 153 123 156 0.89

3 8 0.0023 3.7 9.3 0.3 21 44 157 180 153 184 0.91

4 8 0.015 24 6.7 0.1 21 45 185 209 182 213 0.91

5 8 2.9e-05 0.046 15.4 0.1 21 45 213 237 209 244 0.87

6 8 0.049 79 5.0 0.1 21 44 241 264 237 268 0.91

7 8 3.9e-05 0.063 15.0 0.3 21 44 269 292 265 297 0.91

8 8 0.0001 0.17 13.6 0.1 21 46 297 322 293 324 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	6.8	1.1e+04	-1.8	0.1	25	36	105	116	88	132	0.63
2	8	0.33	5.3e+02	2.4	0.1	23	45	131	153	123	156	0.89
3	8	0.0023	3.7	9.3	0.3	21	44	157	180	153	184	0.91
4	8	0.015	24	6.7	0.1	21	45	185	209	182	213	0.91
5	8	2.9e-05	0.046	15.4	0.1	21	45	213	237	209	244	0.87
6	8	0.049	79	5.0	0.1	21	44	241	264	237	268	0.91
7	8	3.9e-05	0.063	15.0	0.3	21	44	269	292	265	297	0.91
8	8	0.0001	0.17	13.6	0.1	21	46	297	322	293	324	0.91

Coding Sequence: ATGTCTGTTTGCGATTCTCTTATTAAAACCGAATTAAAAGATGACTGGGGGCAAATAAAAGTGGAAGAAAACTTTTTTGGGGACGCAGGTGAGTCAACAAAAGAAGAGCCTGTTTCTGAGTCAGATTTTTGGATAGAGCACCAAAAGAAAATGTATCTTCACGATCCAGTTAAAACTGAGTTAGAAAACGACGGGAGGGAAATAAAAGTGGAAGAAAAATTTATCGTAGATGAAAGAATGATTTCGTGCGGCATAAGTAACAATGAAATAAGAAATGAACCGAATGAAAGGAGTGACAATGGCGCAAATAGATTCAGTTGTCCTGATTGTCCGAAAGTCTACACCAGCATCAGCGGGTTGAAATGCCATTCTTCCATACATACGGGGGTGAGACCGTACGAGTGCAAGATGTGTAAGAAAACGTTTCGTTTGACACAAACGCTGAGGGTCCACATGAAGTGTCACACGGAGGAGAAGCCGCACGTCTGCGAAATTTGTAAAAAGACGTTCCGCCACCACCAAAATCTGAAAAGCCACGTGCTGTGCCACACCGGCGAGAGGCCGTACATATGCGAAATTTGCAAATTCGGATTCCGTACCTCCGATAAACTAAAGTGTCACTTGAGGTGTCATACGGACGAGAGGCCCTacgagtgtgaaatttgcaaaaagTGGTTTCGTCAGTCGAAAAACCTAAAGATGCACATGATGTGTCACACGGACGAGAAGCCCCACAAGTGCGAAGTGTGTAAAAAAGGGTTCCGCGCTGCTCATAAATTGAGGATTCacatgatgtgccacacagacgaGAAACCGTGCGTGTgcgaaatttgcaataaaggcTTCCGTCAGTCCAACAATCTAAAGATCCACATGAGGTGTCACACGGAAGAGAAGCCCTACGAgtgtgaaatttgtaaaaaagtgTTTCGTCACTCTCAAACGCTGAAGGGTCATATGGAGTGTCATGCAAATTAG
Protein Sequence: MSVCDSLIKTELKDDWGQIKVEENFFGDAGESTKEEPVSESDFWIEHQKKMYLHDPVKTELENDGREIKVEEKFIVDERMISCGISNNEIRNEPNERSDNGANRFSCPDCPKVYTSISGLKCHSSIHTGVRPYECKMCKKTFRLTQTLRVHMKCHTEEKPHVCEICKKTFRHHQNLKSHVLCHTGERPYICEICKFGFRTSDKLKCHLRCHTDERPYECEICKKWFRQSKNLKMHMMCHTDEKPHKCEVCKKGFRAAHKLRIHMMCHTDEKPCVCEICNKGFRQSNNLKIHMRCHTEEKPYECEICKKVFRHSQTLKGHMECHAN

Sequence clustering based on sequence similarity using MMseqs2