Basic Information

Gene Symbol
IBTK
Assembly
GCA_905147715.1
Location
LR990650.1:9835110-9854603[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 9.9e-16 9.7e-13 50.3 0.0 7 80 218 290 211 302 0.90
2 4 8.9 8.7e+03 -1.1 0.0 88 108 362 383 355 395 0.63
3 4 1.2e-13 1.1e-10 43.6 0.0 9 107 411 513 406 516 0.86
4 4 2.8 2.7e+03 0.5 0.2 80 107 518 545 513 548 0.87

Sequence Information

Coding Sequence
atgccaggatgttctctaagatggtacATTAAACCCGACCATGAAACCAACCAGACGTATCATTTCAACTCTTACAACCTAGCGAACCTGATCACACTACACAGATGTGTGATCAGGTTCGCTAGACAAATAAACCTGCGTCAAGTGTGTGTAGAAGCTAAAGTGAACGACCAGGGTGTGTACTCGCGAGTGACAGTACTCCTGCTTACCAACGTGGGGCAGCTGTTCATATGGCAGGACACCACTAACAAACTTACAAGATGCGTATTCGGCCTCGTCCAccaaacaataataacaaacgTAGCGCTCACCCACGACGCTCTCTACTTCACGACTAAATACGGCGAAGCGTTCATTGGCACGATCTCACGCAAAACCACGCCCACCACGCCACAGCAGCCAATCAAGAAGGAGAAGGAGAGAGACAACAAGCCCGCGCTTGTCAAGTTTTTAGAAAAGGACGACTGTACTTCAGTCAGGATCGCGAAGATACCGAATGTTTATAGAGCGGTGTCTATTGCTGTGGATAGTGAGGGACTTAATTTTGCTTGTCTACAGATTAAACCGACTTGCGGCCTGATGTCATTACCACAACTGTCACCGACCAGCATGTCCAAGCACATGGAATCTCTCCGGGAATGTGCCTCCGAAGATGATCTGCTGCATGATGTGGTGTTCAAGGTCGGCACAAAGCTCTTCCCCGCGCACATTTTCATCGTAGCTTCAAGCAGTGAGCTCCTCTACAAACTATACCAGGACAACATAACCGCGCCGGGCGATAAGCCCGAGGTCACTCTCGACAACGTTCACCCTGAAGCCTTCAAGAGAATCATGAAGTTCATGTACACCGGCACTTGTGACGTCACGGAGTTGGGACCTTGTGGACTGCAGATCACGAAGGAAGAATTAGTGAAGAAGGTCAAGGATTGTGATGAAGAGGAGGAGATGATTGAAAATCCCTCCGAAATATCAGCTTTCGAGGTCTACAATAAACCTCAGGACAAGTCGAAGCGACAACGCAACCGCCGCAACACCGACACACCGCCGCGCACCCATCTGTACTGTGACCCCGTCAAGCTGCTGCAGGCCTCCGCTAAGCGACTGCAGGTCATGAGTCTACACAAACTGCTGGATAAGTTCTACTACAAGAACGGCTCCATATGTCTGAAGGAGAGCGCGAGCGCGAGCTACAGTAGCAGCCCGAGCCGCTGGGAGCGCGACGCCTTCCCCGAGCTGGTGGACACCAGCGTGGTCTCCAAGGACGGCGCCAGGGTACCCGCGCACAAGTGTGTGCTGGCGGCCAGGCTGGACTACTTCCACGGAATGTTTATGCATTCTTGGACTGAGAGCAAGAAGCTGTCAACAGTAACTCTCCCAATAAACTACGGCATCCTACTGCCAGTCATCAACTTCCTATACACCGACTTCTGCCCAGAACTGGAAAACTGTGACAGCATCGACTTCATATGCAATCTCCTTATAGTCGCCGACCAGCTGTTCATATCGCGACTGAGAGAAATGTGCGAGATCGCACTAGCAAACCTTATCAACCTCAAGAACTGCACAGAACTCTGCCAGTTCGCACACACGTACAACGCAACCCAACTCAAACAATGCTGCATGCAATTCATCGCGCTAAACTTAAACTGTGTACTAGAGAACAGATCTTTAGATCTGCTAGAAGAAACCTTACTGGACGATATAACTCAGTATTATTGCAAATTCAACCCTATCATGTCTTCCAGAGTAATCACTCCATTTTACAACGCTCCAGATGATGAAGTTATTGAAGAGTTTGCTAAAACACACCCTGTTAACTTAGAGCTAACGGATGAGGATATCAAGAGAGATGACAGTATAATAGAAATAGTTAGTAAGAAGAAAAGGGGAAAGAAGATTGAATACACTGATAGTGAGAAGGAGAGGATGAGGTACGAATCTGTAAGCTCGGTGACGTCATTAGACCTGTCTAATGATACCTCCGGGGACATTACTCTATCGTTGAGTAAGATATCTAAGGAATCTGAGAAAGGAACGCGGGACAAGCAGGAGAAGTGGACCGAAGTGCCATCGTCACAGCAGAAACAATTGAAAGTCGTCCAAGCAAGACTAAAAGCCATAACCATTGCGAAAGATATATTGAATGAGGCTCCCGCCGAATCGTTTACGAAACTTACGAAGAGTAGCTCTTCCAGTGCCATGacaatacaagaaaaattacCTACCTCAACAAGAATGTCTGTGTCACCTAACGATTCTCCAATTGCTGAACATGCATGGAGTCCAAAACAGGGAAACTTAGTTATAAGCCACGTGGGACCAAAACTATCTcagaaacaaagaaaaaagttGGCTTTGCAAGGAAATGAAACAGCATCACAGAGTATTGAAGACTACTTTACTAAGGTAAATGTGGGTAGTCCACCTGAAAAGCCGAAGAATCCGTGGAAGATCTGTGAGGCACCGGTTGCTAGCAGCAGCCCTAAATCAAAATCCATAgagtttaataaaatattgacTGATCAGAGGAAACAGAAGGAAGATCACTCGAGAATCATGACCAAACCGCTAATTTTGACTCAGCTTGAAGACAAAGCTATAGAGCAACTGGAGAGATTCTACAACGTCCATGAGATAGACGACGAGTTGATCACCGTCCGCCGCATCGAGCTGCAAGTGTCTTCTCCACAATGGTTACACACTGCCCCTAAGTGA
Protein Sequence
MPGCSLRWYIKPDHETNQTYHFNSYNLANLITLHRCVIRFARQINLRQVCVEAKVNDQGVYSRVTVLLLTNVGQLFIWQDTTNKLTRCVFGLVHQTIITNVALTHDALYFTTKYGEAFIGTISRKTTPTTPQQPIKKEKERDNKPALVKFLEKDDCTSVRIAKIPNVYRAVSIAVDSEGLNFACLQIKPTCGLMSLPQLSPTSMSKHMESLRECASEDDLLHDVVFKVGTKLFPAHIFIVASSSELLYKLYQDNITAPGDKPEVTLDNVHPEAFKRIMKFMYTGTCDVTELGPCGLQITKEELVKKVKDCDEEEEMIENPSEISAFEVYNKPQDKSKRQRNRRNTDTPPRTHLYCDPVKLLQASAKRLQVMSLHKLLDKFYYKNGSICLKESASASYSSSPSRWERDAFPELVDTSVVSKDGARVPAHKCVLAARLDYFHGMFMHSWTESKKLSTVTLPINYGILLPVINFLYTDFCPELENCDSIDFICNLLIVADQLFISRLREMCEIALANLINLKNCTELCQFAHTYNATQLKQCCMQFIALNLNCVLENRSLDLLEETLLDDITQYYCKFNPIMSSRVITPFYNAPDDEVIEEFAKTHPVNLELTDEDIKRDDSIIEIVSKKKRGKKIEYTDSEKERMRYESVSSVTSLDLSNDTSGDITLSLSKISKESEKGTRDKQEKWTEVPSSQQKQLKVVQARLKAITIAKDILNEAPAESFTKLTKSSSSSAMTIQEKLPTSTRMSVSPNDSPIAEHAWSPKQGNLVISHVGPKLSQKQRKKLALQGNETASQSIEDYFTKVNVGSPPEKPKNPWKICEAPVASSSPKSKSIEFNKILTDQRKQKEDHSRIMTKPLILTQLEDKAIEQLERFYNVHEIDDELITVRRIELQVSSPQWLHTAPK*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2