Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 1.9 2.4e+04 -2.8 0.0 20 36 9 25 5 26 0.82

2 7 0.037 4.7e+02 2.6 0.0 3 36 41 74 39 75 0.89

3 7 0.037 4.7e+02 2.6 0.0 3 36 90 123 88 124 0.89

4 7 0.037 4.7e+02 2.6 0.0 3 36 139 172 137 173 0.89

5 7 0.037 4.7e+02 2.6 0.0 3 36 188 221 186 222 0.89

6 7 0.037 4.7e+02 2.6 0.0 3 36 237 270 235 271 0.89

7 7 0.032 4e+02 2.8 0.0 3 36 286 319 284 333 0.90

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	1.9	2.4e+04	-2.8	20	36	9	25	5	26	0.82
2	7	0.037	4.7e+02	2.6	3	36	41	74	39	75	0.89
3	7	0.037	4.7e+02	2.6	3	36	90	123	88	124	0.89
4	7	0.037	4.7e+02	2.6	3	36	139	172	137	173	0.89
5	7	0.037	4.7e+02	2.6	3	36	188	221	186	222	0.89
6	7	0.037	4.7e+02	2.6	3	36	237	270	235	271	0.89
7	7	0.032	4e+02	2.8	3	36	286	319	284	333	0.90

Coding Sequence: ATGTTCGAGGACGCCGACACCGAGCAGCGAGGGGCCATCACCTACGAGGCGCTCAAGAAGCAGCTCGGGAACCATGATGGGCTGTTGGAGAACCTGTCTATCAGaggtcagttCAGCGACGAGCAGCTGCACCACCTCACCAGCGCCATGTTCGAGGACGCCGACACCGAGCAGCGAGGGGCCATCACCTACGAGGCGCTCAAGAAGCAGCTCGGGAACCATGATGGGCTGTTGGAGAACCTGTCTATCAGaggtcagttCAGCGACGAGCAGCTGCACCACCTCACCAGCGCCATGTTCGAGGACGCCGACACCGAGCAGCGAGGGGCCATCACCTACGAGGCGCTCAAGAAGCAGCTCGGGAACCATGATGGGCTGTTGGAGAACCTGTCTATCAGaggtcagttCAGCGACGAGCAGCTGCACCACCTCACCAGCGCCATGTTCGAGGACGCCGACACCGAGCAGCGAGGGGCCATCACCTACGAGGCGCTCAAGAAGCAGCTCGGGAACCATGATGGGCTGTTGGAGAACCTGTCTATCAGaggtcagttCAGCGACGAGCAGCTGCACCACCTCACCAGCGCCATGTTCGAGGACGCCGACACCGAGCAGCGAGGGGCCATCACCTACGAGGCGCTCAAGAAGCAGCTCGGGAACCATGATGGGCTGTTGGAGAACCTGTCTATCAGaggtcagttCAGCGACGAGCAGCTGCACCACCTCACCAGCGCCATGTTCGAGGACGCCGACACCGAGCAGCGAGGGGCCATCACCTACGAGGCGCTCAAGAAGCAGCTCGGGAACCATGATGGGCTGTTGGAGAACCTGTCTATCAGaggtcagttCAGCGACGAGCAGCTGCACCACCTCACCAGCGCCATGTTCGAGGACGCCGACACCGAGCAGCGAGGGGCCATCACCTACGAGGCGCTCAAGAAGCAGCTCGGGAACCATGATGGGCTGTTGGAGAACCTGTCTGTTATATACGTGGGTAATTATAAGCAATCGCGCACTTGTACCGTCAGCTCAGTTCAAATATACGCTCGGTTCGAACACACGTCTTTTATTTAg
Protein Sequence: MFEDADTEQRGAITYEALKKQLGNHDGLLENLSIRGQFSDEQLHHLTSAMFEDADTEQRGAITYEALKKQLGNHDGLLENLSIRGQFSDEQLHHLTSAMFEDADTEQRGAITYEALKKQLGNHDGLLENLSIRGQFSDEQLHHLTSAMFEDADTEQRGAITYEALKKQLGNHDGLLENLSIRGQFSDEQLHHLTSAMFEDADTEQRGAITYEALKKQLGNHDGLLENLSIRGQFSDEQLHHLTSAMFEDADTEQRGAITYEALKKQLGNHDGLLENLSIRGQFSDEQLHHLTSAMFEDADTEQRGAITYEALKKQLGNHDGLLENLSVIYVGNYKQSRTCTVSSVQIYARFEHTSFI*

Sequence clustering based on sequence similarity using MMseqs2