Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.73 6.3e+03 -2.1 0.1 58 67 6 15 4 18 0.70

2 4 0.081 7e+02 1.0 0.9 2 18 46 62 45 75 0.80

3 4 3.4e-05 0.29 11.8 0.1 2 26 124 148 123 151 0.88

4 4 4.6e-21 4e-17 62.6 14.6 3 69 256 322 254 323 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.73	6.3e+03	-2.1	0.1	58	67	6	15	4	18	0.70
2	4	0.081	7e+02	1.0	0.9	2	18	46	62	45	75	0.80
3	4	3.4e-05	0.29	11.8	0.1	2	26	124	148	123	151	0.88
4	4	4.6e-21	4e-17	62.6	14.6	3	69	256	322	254	323	0.97

Coding Sequence: ATGGTGCTAGCAGCGCGATGCCGAGTGTGCGGGGAGGTGATCAGTTACACGCAAAACAACCCGGAAGTACTCGGAGAACATCTCCTGAACCGACATCCTGATATTGATGTCGCTAATCTGACTTGCATGAATGAACAATCTAGTTCAAGTTCCTGTCATGTATGTCAAGAAAACCGCAATACTTATCCAAATTGTCACGCAACTTATAATTTATCAACGAATTGGCCTTCAGAAGGCTACCAAACATCAAGCTGTCATCCTGTCTGCCCAACAAACTGCGATGCCGCAAGAAGTGGCGAATGTGGAAAAAATGCTTGTCCGTCGTTTAGAAGAAAACTTTATAAAACAAcagTTGAAACTTGGCACCCAGGTCCGGGCGAAATAGAATGTCCAAAATGTGGACAAACAGGGACTCCATTAATACGTAAACAACGCAATAAGTTATCAACAAATAATGGAGAATCTAGTACCGGAGTCTACATCAGTCCTCCAAGAATTACTCACACCCTTCCACCAGCTAGCATGGCACCACCAAGCTACAGCACCATTTCATGCAATTTGCCAAGGCCAACAAATAGAACAGcTTCAAGACGATCAACTACCCTTAGAATTCAACCATCTCCCCCATTTATTGCACCGATTCCACCTCCTACATATTACGAAAGTGAAGGAACACATTTGAGAACAGACAACCGAGAACTTAGGATTCCTATAACCGTTTTAGATATGTCAACAGTAAACTATAATCGAATTTGGGGTGCAGTTCCTGTCTCGACAACGTGTACCTACTGCCATCGGTTAATGGTAACCGAAACGCACATGCATATTACATCGTCAACTCATTTCACGGCCCTAGTTTTGTTCTTGTTATTTTGCTGGCCATGTTGTCTTCTGCCGTACTTAATGCCAACCTGCAAAGGCGTTCATCATCATTGTCCTTACTGTGATTCCATAGTTGGTGTATATGTACCTTGGTCCCGTCCACTACACTGA
Protein Sequence: MVLAARCRVCGEVISYTQNNPEVLGEHLLNRHPDIDVANLTCMNEQSSSSSCHVCQENRNTYPNCHATYNLSTNWPSEGYQTSSCHPVCPTNCDAARSGECGKNACPSFRRKLYKTTVETWHPGPGEIECPKCGQTGTPLIRKQRNKLSTNNGESSTGVYISPPRITHTLPPASMAPPSYSTISCNLPRPTNRTASRRSTTLRIQPSPPFIAPIPPPTYYESEGTHLRTDNRELRIPITVLDMSTVNYNRIWGAVPVSTTCTYCHRLMVTETHMHITSSTHFTALVLFLLFCWPCCLLPYLMPTCKGVHHHCPYCDSIVGVYVPWSRPLH

Sequence clustering based on sequence similarity using MMseqs2