Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0026 2 9.1 0.1 26 47 163 184 148 190 0.80

2 7 7 5.3e+03 -1.8 0.0 23 43 188 208 184 213 0.80

3 7 0.19 1.5e+02 3.2 0.2 21 43 214 236 206 241 0.89

4 7 0.0045 3.5 8.4 0.0 21 43 242 264 234 270 0.89

5 7 0.02 15 6.3 0.0 21 43 270 292 265 298 0.90

6 7 0.056 43 4.9 0.0 21 48 298 325 295 331 0.85

7 7 3.1 2.4e+03 -0.7 0.0 22 43 327 348 324 352 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0026	2	9.1	0.1	26	47	163	184	148	190	0.80
2	7	7	5.3e+03	-1.8	0.0	23	43	188	208	184	213	0.80
3	7	0.19	1.5e+02	3.2	0.2	21	43	214	236	206	241	0.89
4	7	0.0045	3.5	8.4	0.0	21	43	242	264	234	270	0.89
5	7	0.02	15	6.3	0.0	21	43	270	292	265	298	0.90
6	7	0.056	43	4.9	0.0	21	48	298	325	295	331	0.85
7	7	3.1	2.4e+03	-0.7	0.0	22	43	327	348	324	352	0.86

Coding Sequence: ATGGCGACGATTCAGGGCAGTTCTTATGAAGAAACAGATTTCGGAAATGCAAATTCTGACACAAACCGTGAACAAACTAAACTTGATATTACCGACGTGAATACAGGAGCTAATGCAAGTCTTGGAGACGTAAAATTAGACTCTAAGCCTCAGGAAAGATGGAACGTGCCAAATTCTGGAGAAAGCATTGCTACAACAAATGTAGTATATATAAAATGTGAGCCCCAATTTGATACTTATTTAGATTACGAAGgaaatataaaacaagaaaatgaaaattttgaacCTCAGGTGATACTGAAAACGGACGAAGATTTTGATAGTTCACCGAACACCGATTTGAAAGTAAAATTTGATTCCTGCTTTGATGAATcttctaaaaattttatgaatattaAACAAGAAAATGGAATGTCTTCCAAACTGTGCGATAGTGAGCGGTCAGTTAAAAAAAGGGCACGCAAAGGAATGAAACGGAAGttatatcagtgtgacgtttgttaCAAGTATTTCACCGATTCAAGCAATTTAAATAggcacaaacgtatacatactggaaGAAAACCGTATAAATGTAATGATTGTGATAGGTGCTTTACACTttcatttgatttaaaaagaCATAAGTTAATACACACCGGCGAGAAACCATatcggtgtgacgtttgtaataagtgtttctctcaatcaaacattttaaaatttcataagtATACGCATACAGGTGAGAAGCCGTACCAGTGTGATATTTGCTACAAGAGCTTTACTTTATCGTTTGACGTTAAAAGACATAAGTTAACACATACAGGAgaaaaaccgtatcagtgtgaagtttgtaataaatgtttctctCAATCAAGCGGCCTAAAGAAACATACGCTTACGCATACAGGGGAGAAACCGTTTCGGTGTGAAGTTTGTGACAAGTGTTTCTCTCAATTAGGGAATTTAAACAAGCATAAGCTattacataccggtgagaaaccgtatgagTGTGACGCTTGCAGTAGATGTTTCACTGACGGAGGCAATTTTAATAGACACAAACGTACACATATTATAAGAGAATAG
Protein Sequence: MATIQGSSYEETDFGNANSDTNREQTKLDITDVNTGANASLGDVKLDSKPQERWNVPNSGESIATTNVVYIKCEPQFDTYLDYEGNIKQENENFEPQVILKTDEDFDSSPNTDLKVKFDSCFDESSKNFMNIKQENGMSSKLCDSERSVKKRARKGMKRKLYQCDVCYKYFTDSSNLNRHKRIHTGRKPYKCNDCDRCFTLSFDLKRHKLIHTGEKPYRCDVCNKCFSQSNILKFHKYTHTGEKPYQCDICYKSFTLSFDVKRHKLTHTGEKPYQCEVCNKCFSQSSGLKKHTLTHTGEKPFRCEVCDKCFSQLGNLNKHKLLHTGEKPYECDACSRCFTDGGNFNRHKRTHIIRE

Sequence clustering based on sequence similarity using MMseqs2