Basic Information

Gene Symbol
-
Assembly
GCA_963575645.1
Location
OY754475.1:20045672-20049752[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.00094 0.019 15.9 1.4 1 23 270 294 270 294 0.98
2 18 0.00037 0.0075 17.2 1.1 1 23 300 324 300 324 0.96
3 18 1.1e-06 2.2e-05 25.2 3.1 1 23 330 352 330 352 0.99
4 18 0.0073 0.15 13.1 3.4 2 23 707 729 706 729 0.96
5 18 0.0011 0.022 15.7 7.8 1 23 731 754 731 754 0.97
6 18 1.7e-05 0.00036 21.3 5.2 1 23 842 865 842 865 0.98
7 18 8.3e-05 0.0017 19.2 3.0 1 23 874 897 874 897 0.97
8 18 0.26 5.4 8.2 1.1 1 23 909 931 909 931 0.94
9 18 2.1e-05 0.00044 21.1 2.8 2 23 943 964 942 964 0.97
10 18 0.00018 0.0038 18.1 6.9 1 23 971 993 971 993 0.99
11 18 0.46 9.4 7.4 0.2 3 22 1002 1019 1000 1021 0.77
12 18 4e-05 0.00083 20.2 3.4 1 23 1027 1049 1027 1049 0.97
13 18 0.00014 0.0028 18.5 2.8 2 23 1055 1077 1054 1078 0.95
14 18 0.0015 0.03 15.3 0.9 1 23 1082 1105 1082 1105 0.96
15 18 0.00028 0.0057 17.6 0.4 1 23 1111 1134 1111 1134 0.96
16 18 4.7e-06 9.6e-05 23.1 4.1 1 23 1140 1162 1140 1162 0.99
17 18 1.6e-06 3.3e-05 24.6 3.0 1 23 1168 1191 1168 1191 0.98
18 18 0.00062 0.013 16.5 1.1 1 23 1197 1220 1197 1220 0.93

Sequence Information

Coding Sequence
ATGAATAAACGACTAGTAATTGACGCGGTAGGATTAAAACAGGACATATGTCGATTTTGTTTAACAATGGACGTTCAACTAGCCCACATTTATAGCGGTTCAAGTAATCTTGGGAGTACTATAGCTGAAGCTGCCATGGAATGTGCCACTATTCAGATTTCACTGAATGATGGCTTGCCACTGTACGTCTGCAAAGATTGCTTTTTGAAACTTCAAGACGctcaacaatttaaaaaaatggtcctCAAATCCGACTCTGCGTTAAGAACTTATCTCAAACAGCTGCGTATTGACCGCCACTCAACGAGAAGTAGTTTTCCCATAAAGGATGACCCTTTTGACCTTGACGAGGCACGGTGTACGGATCAAAATGACGACAAAATGAAGACTGAAGACACTGACAATAATATCACGGCATCAACGACGTTGGAAGACATCACTTCTAATTCCgaggaaaatatcaatttagTAGATTATAGTTCCattgaaaaattaagttcatccatttcagaaaaaaacagaTCAGATGCACAAAGCGAATTCGAAAATAGAAATTTTGTAGATAGTGAAATAATAGACGTTGGTGAATCTGATGATCGAGAAATAAGTGGAAATACTTCTGACTATGCTGTAGAAACAGATGCAACAAGTTCCGGGACAGAAGAAGACGCAGACGATTGTGAAATACAGGAATCGGTGTCAAGAAATTATGGTTCCGAACAACAAATGCATGACGGTTCACAAACAGTCAAAGTGAAAAGAGGAACGTTCAGTGAAGGAGAAAGGCATTCGGATCATGAAAAGCAGTACGAATGTCACATGCCAGGATGCAGCAAAGTTTATGGGAAAGAATCGCATCTTTGGGTTCATTTAAGGCGGCACACCGGAGAAAAACCCTTTGTATGCGATTGGCCGTTCTGCAGTAAAGATTTCACCAGCTCCAATACATTGCAAAGACATCAGAAATCTCATACTGGAGAAACACAATTTCAATGTCCCGAATGCGATAAGAAGTTTATGCGTAGGGATCATTTATCAAAACACATTAATACTCATACGAAACAAAAGACAATGGAGGCAGCTACATCAACTCAATCTGCTTCTTTAGACACTTCTGGCGGCGCTGAAAAAATGTTGATCACTTTTACTACAGAAACTGACCAATCGGATTTAACTATTGCCGATGGTTTAGAATCTTCGATATTGAGTTGTATCAAGCCTTTACCGAAATCCACTGATGGAGTTTGTGAAACGCCTACAGAAAAAGGCATAAGCAATGAAAAAACACAAACACAAGCAAATACCACAAAAATTAATGAATCTTTGAGTGAGCGAATTGATAGTGTAATCTCAGCCAGTTTCCATACAGGAAATAATACTGCATCAAGTTTAAAACCCGACCAGCAAGAAAATACCAACTCAGAGTCGGCTGATCAAAGTTTAGAAGCTAAAAGCGACGAAACTTTGGGAAATATTAACATTGCAGAGTGTGAAAAAATAGATAGTAATAAATCCAATGATCACGAAACAAGTGGGAATATTTCGGATAATTCTTCAGTATCGGACCATACCGATGACTGGGTGTTAGAAGAAGATTCCACTTCTGAAACAGAAGAAGGCTCTGCTTCTGAAACAGAAGAAGATTCCGGTTCTTCTGACGATTCCGCTGAGAATAAATTTaagaacaataataaaaacaatttaaaacgtAAAATGTCTGAAGAAACCTTTTCTAGAAAACGTGTTTTACGTAGACATACAAAGCGTACACCAAACGAACAAGAAACATCggatacttttaataaaatcaattctTCAAAGGAAAATGAGAACTTATTGATTAGTAATGCAGTTGAAAAACTAATTTCCGCCAATTCAGAGAATCACAATTTGGACGTGCAAACCAATGAACCTTTAGAGAAATCGAATATCGCAGATCTTGacatattaaatactaataaACGCAGCGATCAAGAACAATCTGGATGTTTTTCGAATGATAACACTTCGGACAAAGCCGTAGAAAGGGATGATGTTGACGCTCTACATTCAGAAGAAGTGGGGTCGATAGATGATAATTCTGAAAAGGAAtctgagaaaaataaaaacccatttttaaaatgtaaaatatgtaaaaaattgtatatgagTAAAGATAGTTTAtgtaaacatattttgaaagaaCATATGTTTCAGTGTGAAATATGCAATAAAAGCTTtagttcaaaattttgtttatgtaGACATTCGAAAAAAATTCATGGTGCAGCTACAAACGAAAATAAATCGACGTCAAACGAACAAGAACTCAGAAGTGATTTAGAAAAAATGAACTCCTCGAAGGAAAATGACAATTCGGTAAACAATAAATCGGCTAGCCAGAGTTTGAAAACGCAAGTCAAAGAGTCTTTAGAAAAAACAGATCAGGAAAATATATCGGACGTTAACAAACGCAAGGATGATTTTGACAACTCAGGTTCAGAAGAAGTGGGGTCGAAAGAAGATAGTTCTTACGGAATTAAATTCAAAtgtgaaatatgtaaaaaatcctATACTACCAAAGATAGTTTACGAAGACATCATTTGACAAAACATGAAAGCAATTTGACAAAGCATGAATTTAAGTGTGAAAAATGCGAAAAAAATTTTACTCTAAAATATCAGTTACGTAACCATATGACAAAAGTCCatgaatcaaataaaaatgaGAATGAAATCGGCATATATAGCTGCAATACTTGTAATGAAAAGTTTGAAGAACGTCGCGAATTTTACATCCATGAAGTCAGACACTTCGATAAGAATTACCAACCGGGCAAACCTATTCAGTGCAATGTGTGCGACAAGGTGTTTAAGAAACTATCTCATTTAAAAGTGCATAGCAGGAGACATGACGACGACGATAGACCTTTTCAATGCACTAAATGTGATAAAAAATGCAAGACTAAACACGATTTAGCAAGTCACCAACGAGTCCACGGCGACACTAGATTTTGCTCTATATGTCCCATTTGTGGCAAAACTGTAAAGAGTAGCATTCAGCGTCATATCAGCGAACGTCATTCAGAAAATAGACCATACATGTGTCACAAATGTGGAAAATCATACAAAGATATGACCAATTTAACGCGACATAAAGAAATTCACGATGGAAAAATGATTGAATGTAAAATTTGCAACAAAAGTTTTAAAGGGAAAATGTTGTTGcgaaaacatattaaaaatagtCACCACGGAAAAGAATTTAAATgtaacatttgttttaaaatttccagTTCGCAGCAAACTTTAAGAAGTCACATTAAAGGAGTTCACGGAAAGAAACGTGCCTTTGATTGTTCtgaatgtaaaaaaacattttcttctcCAGTGGGTTTAATGTTGCATAAGAAATCAGCCCATAGCAGAGCGAAACCTTTTAAATGTCAAGAATGCGGTAAATGTTTTACTCGTAAGGATTTCTTGGTTATGCACCTAAGGATGCACAGCGGGGAGAAGCCCTACAAGTGTGACAAGTGCGATAAACGTTTTTCACGAAATGACAAtttcaaaatacatttaaaGAAAGTCCATGGCAAGTCTATGAAATACAAATGTCAAGTTTGCGACAagaaattcaaaatgaaacgcGATTTAGATAGTCACATCGAAGATAACCATTATGTGCCCATGTAa
Protein Sequence
MNKRLVIDAVGLKQDICRFCLTMDVQLAHIYSGSSNLGSTIAEAAMECATIQISLNDGLPLYVCKDCFLKLQDAQQFKKMVLKSDSALRTYLKQLRIDRHSTRSSFPIKDDPFDLDEARCTDQNDDKMKTEDTDNNITASTTLEDITSNSEENINLVDYSSIEKLSSSISEKNRSDAQSEFENRNFVDSEIIDVGESDDREISGNTSDYAVETDATSSGTEEDADDCEIQESVSRNYGSEQQMHDGSQTVKVKRGTFSEGERHSDHEKQYECHMPGCSKVYGKESHLWVHLRRHTGEKPFVCDWPFCSKDFTSSNTLQRHQKSHTGETQFQCPECDKKFMRRDHLSKHINTHTKQKTMEAATSTQSASLDTSGGAEKMLITFTTETDQSDLTIADGLESSILSCIKPLPKSTDGVCETPTEKGISNEKTQTQANTTKINESLSERIDSVISASFHTGNNTASSLKPDQQENTNSESADQSLEAKSDETLGNINIAECEKIDSNKSNDHETSGNISDNSSVSDHTDDWVLEEDSTSETEEGSASETEEDSGSSDDSAENKFKNNNKNNLKRKMSEETFSRKRVLRRHTKRTPNEQETSDTFNKINSSKENENLLISNAVEKLISANSENHNLDVQTNEPLEKSNIADLDILNTNKRSDQEQSGCFSNDNTSDKAVERDDVDALHSEEVGSIDDNSEKESEKNKNPFLKCKICKKLYMSKDSLCKHILKEHMFQCEICNKSFSSKFCLCRHSKKIHGAATNENKSTSNEQELRSDLEKMNSSKENDNSVNNKSASQSLKTQVKESLEKTDQENISDVNKRKDDFDNSGSEEVGSKEDSSYGIKFKCEICKKSYTTKDSLRRHHLTKHESNLTKHEFKCEKCEKNFTLKYQLRNHMTKVHESNKNENEIGIYSCNTCNEKFEERREFYIHEVRHFDKNYQPGKPIQCNVCDKVFKKLSHLKVHSRRHDDDDRPFQCTKCDKKCKTKHDLASHQRVHGDTRFCSICPICGKTVKSSIQRHISERHSENRPYMCHKCGKSYKDMTNLTRHKEIHDGKMIECKICNKSFKGKMLLRKHIKNSHHGKEFKCNICFKISSSQQTLRSHIKGVHGKKRAFDCSECKKTFSSPVGLMLHKKSAHSRAKPFKCQECGKCFTRKDFLVMHLRMHSGEKPYKCDKCDKRFSRNDNFKIHLKKVHGKSMKYKCQVCDKKFKMKRDLDSHIEDNHYVPM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01530576;
90% Identity
-
80% Identity
-