Basic Information

Gene Symbol
LZTR1
Assembly
GCA_963575645.1
Location
OY754472.1:2903788-2914261[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 1.3e-11 4.3e-09 37.0 0.3 3 108 351 485 349 487 0.87
2 4 3.2 1.1e+03 0.4 0.0 77 108 486 517 481 518 0.86
3 4 2.2e-18 7.3e-16 58.8 0.0 8 95 581 668 576 684 0.85
4 4 1.4 4.8e+02 1.5 0.0 76 100 683 707 678 716 0.79

Sequence Information

Coding Sequence
atGGAAGCAGCGCAGTTTGATAATGTTCTTACGCTCGACTTTGGTCCATTTGAAACAGTTCATCGATGGAAGCGTATGCCAGAATGCGATGAATTCGTAGGAGCTCGTCGAAGTAAACATACAGTAGTTGCATATAAAGATGCGATTTATGTATTCGGCGGTGACAATGGAAAGAGCATGTTGAATGATTTATTACGATTTGATGTAAAAGAGAAATCATGGGGAAGAGCTTTTGCTACCGGGACTCCTCCTGCACCCAGATATCATCACTCGGCTGTGGTACACGGACACTCGATGTATGTGTTTGGAGGCTATACTGGCGACATTCTCTGTAATTcaaatttgacaaataaaaacGATCTATTCGAGTACCGATTCAGTACGGGACAATGGACAGAATGGAGGTTTAATGGGCGCACTCCTGTGCCTCGATCGGCGCACGGTGCTGCTGTTCACGACGATCGCTTATGGATTTTTGCCGGATATGACGGAAATGCCAGACTCAACGATATGTGGACAATATCGTTAACGaatgaGATTCATACATGGGAAGAAGTGGTACAAAAGGGAGACTGCCCTCCAACATGTTGTAACTTTCCCGTTGCCGTCGCAAGAGATTGTATGTTCGTATTTAGTGGACAAAGTGGAGCTAAAATAACCAATTCGCTTTTCCAGTTTCATTTTAAAGATCGCagCTGGACTCGCATATCGACCGAACATATTTTGCGCGGTGCTCCTCCCCCGCCGGCAAGAAGATACGGACACACAATGGTTGCGTTCGAAAGACATCTTTATGTGTTTGGCGGAGCAGCAGACAGCACTTTACCAAACGATTTACATTGTTACGATTTGGATACCCAAACGTGGTCTGTCATAATGCCAGCAATTGAATCCCACATTCCTTCGGGACGTTTATTCCACGCGTCTGCTGTTATCGGAGATGCTATGTATATTTTCGGCGGTACCGTCGATAATAATGTACGCAGTGGAGAAATGTTCAGATTTCAGTTTTCGAGCTACCCCAAATGTACTTTGCACGATGATTTTGGAAAAATCCTCGAAACGCGTCAGTTTTGCGATGTGGAATTCGTGGTGGGACACGAAGAAGTTAAAATCTCAGCTCATATAGCTCTAGTCGCGGCAAGATCTCAGTGGTTACGAGTACGGATAAGACAAGCGAGAGATGCAAGAGAAAAACATTTAGAGAAAGTATTCGGCACGGCCCAAGTGCCGTTCAAAGATCTTCCCTTGCTTGAAGTTAAATTGTGCGATGCAGTGCCGGAGGCTTTTGAAATGGTGCTGAATTATATCTACACCGACTGTATTGAACCACGAAAAAAAATTGAAGATCCGTTTTCAAATCGTATCGTACTGTTAATGATGGACGTTTATAGGCTGGCCTTACAATTTAATATGAAACGTTTGGAACAGTTGTGTATACAATATTTGGAAGCAACGATAAGCCTCGGAAATGTTTTGgaagcattgcacaatgcatcTAATTTACGACTAATGTTCATTAAAGAATTCTGTCTAAGATTTATTGTCAAAGAACCTAATTATACTCAGATTGTTATGAGCAAAGAATTTGAAACTTTGGAACAACCGTTGATGGTTGAAATAATCAGACGGAGGCAACAGCCCCAACCTACGAGAAGTGTGCAGGAACAACACGATAACTCAGgtattttGGGAACGACGTTGGAACAAGATATGGCGGTGTTTTTAAAAACGGTTGGCAAAGAATTTTGTGATATAACATTGTTGTTAGAAGGATGTACGATACCAGCTCATAAGTCGATTTTGGCAGCCAGATGTGGATATTTTGAGGCTATGTTCAGATCGTTTATGCCTTCCGACAACATTGTTCGGattcAGATCGGTGAAACGACTCCATCGCAAGAGTCGTTCGATTCACTTTTGCGATATATATATTACGGAGATGTCAACATGCCTCCCGAAGATTCTCTATACTTATTTTCGGCCCCGTTTTTTTATGGATTTACAAATAATCGTCTGCAAGCTTTCTGTAAACAGAATCTCGAAATGAACGTAACTTTCGAAAACGTCATACAAATATTAGAAGCGGCCGATCGTATGCAAGCTGTCGATATGAAGAAATACGCGTTGAATTTAATTGTTCATCATTACACGAAGGTGGCACACTTACCAAAAATGCGAACATTATCCCGCGAACTTCTTCTCGACATTATCGACGCCTTAGCGGATAACATGAGTGAAAATAAGATATGTCAAGACATATCTTCAGCGAGTTTAAACAGCGATTCATGA
Protein Sequence
MEAAQFDNVLTLDFGPFETVHRWKRMPECDEFVGARRSKHTVVAYKDAIYVFGGDNGKSMLNDLLRFDVKEKSWGRAFATGTPPAPRYHHSAVVHGHSMYVFGGYTGDILCNSNLTNKNDLFEYRFSTGQWTEWRFNGRTPVPRSAHGAAVHDDRLWIFAGYDGNARLNDMWTISLTNEIHTWEEVVQKGDCPPTCCNFPVAVARDCMFVFSGQSGAKITNSLFQFHFKDRSWTRISTEHILRGAPPPPARRYGHTMVAFERHLYVFGGAADSTLPNDLHCYDLDTQTWSVIMPAIESHIPSGRLFHASAVIGDAMYIFGGTVDNNVRSGEMFRFQFSSYPKCTLHDDFGKILETRQFCDVEFVVGHEEVKISAHIALVAARSQWLRVRIRQARDAREKHLEKVFGTAQVPFKDLPLLEVKLCDAVPEAFEMVLNYIYTDCIEPRKKIEDPFSNRIVLLMMDVYRLALQFNMKRLEQLCIQYLEATISLGNVLEALHNASNLRLMFIKEFCLRFIVKEPNYTQIVMSKEFETLEQPLMVEIIRRRQQPQPTRSVQEQHDNSGILGTTLEQDMAVFLKTVGKEFCDITLLLEGCTIPAHKSILAARCGYFEAMFRSFMPSDNIVRIQIGETTPSQESFDSLLRYIYYGDVNMPPEDSLYLFSAPFFYGFTNNRLQAFCKQNLEMNVTFENVIQILEAADRMQAVDMKKYALNLIVHHYTKVAHLPKMRTLSRELLLDIIDALADNMSENKICQDISSASLNSDS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01289059;
90% Identity
iTF_01510855;
80% Identity
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