Wsmi002548.1
Basic Information
- Insect
- Wyeomyia smithii
- Gene Symbol
- ZNF646
- Assembly
- GCA_029784165.1
- Location
- CM056644.1:27937657-27938703[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 10 0.0056 0.61 12.4 0.3 1 14 33 46 33 50 0.89 2 10 1.2e-05 0.0014 20.7 2.3 1 23 89 111 89 111 0.98 3 10 2.8e-07 3e-05 25.9 0.2 2 23 120 141 119 141 0.97 4 10 1.4e-06 0.00015 23.7 1.1 1 23 147 169 147 169 0.98 5 10 1.2e-05 0.0014 20.7 6.3 1 23 177 199 177 199 0.98 6 10 4.3e-07 4.6e-05 25.3 1.1 1 23 205 227 205 227 0.98 7 10 0.38 42 6.6 0.3 1 16 235 250 235 252 0.87 8 10 3.1e-05 0.0033 19.5 0.3 2 23 264 285 264 285 0.97 9 10 4.9e-05 0.0054 18.8 1.2 1 23 293 315 293 315 0.98 10 10 0.00018 0.02 17.0 0.3 1 23 321 343 321 343 0.98
Sequence Information
- Coding Sequence
- ATGAGAAAGAACTGCACAGATGCGATTTTTGTGGAAGAAGCTTTGTTCATCGCTACAAACTCGCACAACATTTGGACACACAGTGATGAACGACGGTACCAGTGCAACATCTGCGGTAAACAGTACAAGACAAGAGGAGTTCTTTACAATCAAAGAAGAGTACATAACGGCGAACAATCGTCCAAGTTCGACGAATCCGGCGGAACGATCAGTAAGCTTAGGAATCACTCAAATCATATGTCCACTCACAGTGACGTGGAAAGGTACAGATGTGACATCTGCGGCAAGGATTACAAATCAACAACAAATCTTAATCAGCACAAGAAGTATCACACATCTCATGAGGATGAACTGCTCAAATGCCCCGACTGCGGGAAAGGTTTCGTATATCGCTACGCACTTGTAAAACATATGACCACTCACAGTAACGAGCGAGAGTTCGAGTGCGACATTTGTGGCAAATCGTATAAAACGGCAACTAATCTCTATGATCATAGGAAGTATCACATATCCGGTGAGAACAAACTGCACAGATGCGACAATTGTGGAAAAGGTTTCGTTTATCACCATTTACTCTTAAGACATATGCGTACTCACAGTGATGAGAGACGGTACAGGTGCGACATATGCAGTAAagatttcaaatcggcaagtAATCTTAGTGAGCACATGAAATATCACACAACCCGTGAGGATGAACTGCACAGATGCGACTTTTGTGCGAAAACTTTCGTTTATCGCTCGGTCCTCTTAAATTATATGCACGCTCACAGTGACGAGCGAAGCCGTAGATGCGACATCTGCGGCAAGGAATACAAATCACCAGCAGGTCTGAATCAACACAAGAAATATCACACATCCCATGAGAATGAACTACACAAATGCCCAATTTGCGGAAAAGGTTTCGTGCATCGCCGCATACTCGTAGAACATATAAACACTCACAGTGACAAGCGTCGGTATGAGTGCGATATCTGCGGCAAGCAGTACAAGGCAAGAGGAGGACTTTACGTGCACAAGAAAATGCATAACGGTGAACAATCGTGA
- Protein Sequence
- MRKNCTDAIFVEEALFIATNSHNIWTHSDERRYQCNICGKQYKTRGVLYNQRRVHNGEQSSKFDESGGTISKLRNHSNHMSTHSDVERYRCDICGKDYKSTTNLNQHKKYHTSHEDELLKCPDCGKGFVYRYALVKHMTTHSNEREFECDICGKSYKTATNLYDHRKYHISGENKLHRCDNCGKGFVYHHLLLRHMRTHSDERRYRCDICSKDFKSASNLSEHMKYHTTREDELHRCDFCAKTFVYRSVLLNYMHAHSDERSRRCDICGKEYKSPAGLNQHKKYHTSHENELHKCPICGKGFVHRRILVEHINTHSDKRRYECDICGKQYKARGGLYVHKKMHNGEQS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01525048;
- 90% Identity
- iTF_01525048;
- 80% Identity
- iTF_01525048;