Basic Information

Insect: Wyeomyia smithii
Gene Symbol: MBD-R2_1
Assembly: GCA_029784165.1
Location: CM056645.1:92815449-92819862[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.8e-14 1.9e-10 41.9 0.0 4 75 432 501 429 502 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.8e-14	1.9e-10	41.9	0.0	4	75	432	501	429	502	0.92

Sequence Information

Coding Sequence: ATGGGTATTCGCAAATGCATTATAAGTGACTGTCCAAGCAGCTCAGCTCGGAAAGAGGATCGAGGCGTTACCTATCACAAAATTCCAGCTAATGAGCAGAACAAGAAAAAATGGGTTCTCGCTTGCCGCTTACCAGATAATTACGTTATAAATAAAGGTTCAAACGTTTGCAGTCGGCATTTCCGTAAAGCAGATTTTCAAGATTTCAAAGGTACCAAGTATGTTTTGAAGTTTGGTGCTGTTCCAACAATTTTCTCTTGGAGCATTGCTTCCGTTCCGAATAAGAAGAAGAAAGATGATACTGCGAATTTAGACAAAGCGAAAGGGTCGTTTAAAAAGGATTTAATAGATACAGACAAACCGGATGAGCAAAAACAAGATGTTCCCGTAGAGTCAATTAAAATTAAACCAGATCCAGATTCCAAAACCGAGGATGTGTCAAATGATAACGAAAGTGCAGAACAAGAAGAACCAATCAAACATGAAGTCGCAGATGACGATGTGATCTTGAAGGAAGATACCTTAATAACTCCACTGCTAGGATCTAAGAAAAGATCCGCGACGAAAAGGAAGTCTTCGCCTAGAAAAGCCCCAGCGCGTGGTGCTTCAGCAAAAAAGTCTCGCAAAAGTGAGCCTGCCTCTGTTTCTTCAACATctaaagagaaaaaaacatcACACTCACCTCGAACCAAAATCGAAGCGCAGGACTTTGCAGGCAAGTGGCACCCGGCGAAATTGGTAGAAGTAGACACCGAAGAACGCGAAGTACTTgttcaattcgaaaaaaatggcaAGAGTAAGTCAACTTTGAACGACGAATGGATTCCTATGGACAGCGTCCGACTGAGGCCGCTCCAGGCACCGAAAATACCTAACGAGAAAATCAGCTATGCTATTGGGGAGAAATGCTACGCACGCTGGAGTGATTCACGCAAGTTTCGAGCTACAATCCAGACCATATTGGAGAATGATATGTATGAGGTGTTGTTTGACGACGGGTTTATTAAAGTTTGCAAAGCAAGTCATATAAGCAAATTGAAAAAGAGCGATTACAGTGATCAGGATGCAGAGCCGTTGGCTACACCGATTAAACAAGAAAAAGATTCAGCATCGGTTGAAATAGCTCCGAATATTCCGATCACACCGATATCTGCTCTTTATGTTCCCCAGATTGCTAAGTTGAGCGATTTTCCGGAGGTTCCTAAAGGAGGTGAATGGTGTTGTCACTGGATGAATGATTTTCCGGTCGGAGATGAAGCAACTGCTGATATAGCCGGATTCAAGATACACAGCGTTATTGTACCTGATTGGCGTTTGCCAGACGGATGGGTGAAGCACGTCTATCAGCGTATAACTGCCTATGGAAAGCTAGATGTATTGCTGATCAATCCGGAGGGAAAAGCTTTCCGCTCGCGACAGGAattgaaatctcattttgcaAACAAAGGTCAAGAATATGATATAAACGTGTATGACTTTGGGCTACACAAAAAACGAGCTAAAGAGCTAGGTTTTTGCCATTACACAAAAGAGTACAAGGAATCACTCATTCCGCAGCCGATCAAAACTGAACCCGTCTTGCTAAATACGGAAGTAAATATCGGTTCGGTAAAGGTTAAAATTATTGACAACTTGTTTCAGTGTCCGGAATTAAATTGCTTGAAAACATTCCGCAAGGAGAATCACCTTCAGATTCATATCAAGCATTATCATAAGGAACTCGCTAAAGGTTTAGGTGAGATTCCAAACATGCAAGATTTAGCCTCACTCAGGACGCCAGTAGAAATTCTAGAAGCTCCACACAAATTAACCAGACGCAAGTCAATTTCTGCGTCTGCCTTAAAAAATTTACAGAAAGAAGAAACAAACAAAGAGGATATCATTGTCAAGAAAGAACCTGGATTGGACGATCTTGTAAAAGTTGATTTAAAAAGGGATAGCGCTATAGAGCAAGCATGTGACGTCAAGAAGGAAAATACAGATCTAGGTGTTAAATCTCAGGACTTCACTGAAACGGCTGCCTTAGCGGATATTAAAATACCAAAGCAAGAAATTTCGGCTACTACGATTGCTACCGATGGCGATCCTGAGGAAGCTGTCGAATCTCATATCAAACACAGTGCAAGAAGAGGCGTTACAAAAATAAAGCtcttttcaaagaaaaaaagagggcccaaaaaaacaaaatctggTAACATTTCGGAACGAGTTGCTGTGGTCGCCGCAGGAGCTGCCACCAGGAAGAGGAAGCGCAAACTAAAACTATCACGAACATCCATAGATTATATTGATGCTGACGAAACCTGCCACTCGTTTGCTGGGGGTAGCAATGCTACCGGCACTAATGATAGTTTCTACAGACAAGGCTTTGGCTTTGAAAAGGATACAGAAACGAGTCAAACGACGAACGCAAGCATTTGTGGACAGTATGGTGATGATTCGATCAATGCTGCTATTAGCAGTCCGCGATTCATTAACGAAAACGGAGAAGTTATAAAGATTGTATCGATGAGAAAAGAGGAAATCATCAACTGTCTGTGTGGCTACGGTGAGGAGGATGGTTTAATGGTACAGTGCGAATTGTGTTTGTGCTGGCAGCATGGTATTTGCAATGGATTCGAACGAGATACACAAGTACCAGATAAGTACGTGTGCTACATTTGTCGTAACCCGCAAGGTGGTAGAGAGTCCAGACGTTATATTCACGATCAAGATTGGTTGTATGAGGGTAAACTACCAGTTGCTAACTACCACGTACCAAACCCGAAACATTCTACTCGATTCGATATTCTCAAACAAAGTCACACTTTAGCGGGTAACTTACTGGAGCTAAAACGGTTCATGCATAGTTTGAAAGTTAAGATCAACATCGCAGATAAAAAAGACCATCCTAAAATGTACCTCTGGTCAAAGAAATGGGAAAAGAGTCCTCCGCGAGGCGGTAATGGTGATTTATCAGGAATCGTACCTCCTAATCCGTCTGTTACGTCTGCCGCGACACCACCTACTACGCAAGGATTGCTCAATGCAACAGTAAATCGAAACGACTCATCTGCACAGAAAGCAGCTCCTACTTCTCAAATTCCTGTCCCGGAGGCTCCCATCGATCCAGCTGAGTGTCAAGCCATACTACTGGAGCACATTCAAAAGCAGCAAAATGCCGCAATGGCTCGGCTTCAAGCTATCGAAGCTCAAATTATAGCCCTTGAAGCCTACGATGATAAGTCGGAGCTACTTGAATCTCCTACGGCTAAAAACTACCCTAAGACGAAACAAACCATTCACATGCTATTAAACGATTTAGTTAAAATGAAAAAGATCGCTGCGATTCATAGGAGTGCACAACAACCTCCCCAGTGTTGA
Protein Sequence: MGIRKCIISDCPSSSARKEDRGVTYHKIPANEQNKKKWVLACRLPDNYVINKGSNVCSRHFRKADFQDFKGTKYVLKFGAVPTIFSWSIASVPNKKKKDDTANLDKAKGSFKKDLIDTDKPDEQKQDVPVESIKIKPDPDSKTEDVSNDNESAEQEEPIKHEVADDDVILKEDTLITPLLGSKKRSATKRKSSPRKAPARGASAKKSRKSEPASVSSTSKEKKTSHSPRTKIEAQDFAGKWHPAKLVEVDTEEREVLVQFEKNGKSKSTLNDEWIPMDSVRLRPLQAPKIPNEKISYAIGEKCYARWSDSRKFRATIQTILENDMYEVLFDDGFIKVCKASHISKLKKSDYSDQDAEPLATPIKQEKDSASVEIAPNIPITPISALYVPQIAKLSDFPEVPKGGEWCCHWMNDFPVGDEATADIAGFKIHSVIVPDWRLPDGWVKHVYQRITAYGKLDVLLINPEGKAFRSRQELKSHFANKGQEYDINVYDFGLHKKRAKELGFCHYTKEYKESLIPQPIKTEPVLLNTEVNIGSVKVKIIDNLFQCPELNCLKTFRKENHLQIHIKHYHKELAKGLGEIPNMQDLASLRTPVEILEAPHKLTRRKSISASALKNLQKEETNKEDIIVKKEPGLDDLVKVDLKRDSAIEQACDVKKENTDLGVKSQDFTETAALADIKIPKQEISATTIATDGDPEEAVESHIKHSARRGVTKIKLFSKKKRGPKKTKSGNISERVAVVAAGAATRKRKRKLKLSRTSIDYIDADETCHSFAGGSNATGTNDSFYRQGFGFEKDTETSQTTNASICGQYGDDSINAAISSPRFINENGEVIKIVSMRKEEIINCLCGYGEEDGLMVQCELCLCWQHGICNGFERDTQVPDKYVCYICRNPQGGRESRRYIHDQDWLYEGKLPVANYHVPNPKHSTRFDILKQSHTLAGNLLELKRFMHSLKVKINIADKKDHPKMYLWSKKWEKSPPRGGNGDLSGIVPPNPSVTSAATPPTTQGLLNATVNRNDSSAQKAAPTSQIPVPEAPIDPAECQAILLEHIQKQQNAAMARLQAIEAQIIALEAYDDKSELLESPTAKNYPKTKQTIHMLLNDLVKMKKIAAIHRSAQQPPQC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01524862;
90% Identity: iTF_01524862;
80% Identity: iTF_01524862;