Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 0.069 1.7e+02 1.9 0.0 6 16 10 20 5 34 0.67

2 3 2.1e-13 4.9e-10 38.8 5.1 4 65 108 168 105 173 0.88

3 3 4.8 1.1e+04 -4.0 1.2 5 11 320 326 317 327 0.63

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	0.069	1.7e+02	1.9	0.0	6	16	10	20	5	34	0.67
2	3	2.1e-13	4.9e-10	38.8	5.1	4	65	108	168	105	173	0.88
3	3	4.8	1.1e+04	-4.0	1.2	5	11	320	326	317	327	0.63

Coding Sequence: ATGATAGAGGAGAAGTCGTACATAGCAACCTGGTGCCCAGTATGTGACAAGCAAGTAAGTGTCGAGGAACGAGACACGGACAGACTTCTCACACATATCCGTAAACATCATCCCGAGATCGCTGGCAAATGTTTGAACAATCAAAAAGCGGCGCGCTTTTGTAAATCACAAAGGGCGGAATGCAAGCGGAGCGGGCCGTCACCAAGTGGCATGTTGCTCCCGTGGATTCCGACACTGAAAGCATCCGATGGTAAAACTCGCGCGCCGAAACGACCGAACAATGTCTTCTCCACGGAAGttGAAACATGGAAATACCACGACGAATCAATTCGTTGTCCTGCGTGTGGCGTGAAGGAAGTaccgataatattaaaacaacaGAAATTCACGAGCTCTCGTCTGGCTGCATTTTGTTTAATGGGATGCTGGCCCTTCTGCTTCATACCGTTGCTGATGAGACGTGACAAAAGCACGCGCACGCTGTGTCCGCGTTGCGGTTACGATTACGGAATTTGTACGCGAGCAAAGAGCAAACTGATCGCCTGTTCGTCCAAATGCGCGTTTAGTCGCGGGAAATTAAACGATTTCGCGAATTCACGACCATGTCATCTTCGGGCGGAATACAGCAACTCGCGAGTACAACCGGGATATCGCCAGAAAACACTTTCCATGGGTGACGAGGCCGCGAGAGCTCTCAGGGTCTCGGAGGAGCGTCCTCGGCGTGAAGAAGAAGGCGGATCTCGTTGCTGCCGGTCGCAATCGAAGCTATCGCACGGATACGCCTTTTGTGCGAACCAGGTCACGAATCGCGATTCATCGTACGACGAATGTAGCAGCGACGATTACGTGAACAAAAGATGGGATCGTCGGCGCGACTTGGACGAGTCGAAAGCTCCGAAAGCTCGGGGACACAACGAAGGCAGCACAGGGACGGTGACGGTCGATTTTTATGCGAGACAGGTTTGCTGTCGGGAGTGCGGCTAG
Protein Sequence: MIEEKSYIATWCPVCDKQVSVEERDTDRLLTHIRKHHPEIAGKCLNNQKAARFCKSQRAECKRSGPSPSGMLLPWIPTLKASDGKTRAPKRPNNVFSTEVETWKYHDESIRCPACGVKEVPIILKQQKFTSSRLAAFCLMGCWPFCFIPLLMRRDKSTRTLCPRCGYDYGICTRAKSKLIACSSKCAFSRGKLNDFANSRPCHLRAEYSNSRVQPGYRQKTLSMGDEAARALRVSEERPRREEEGGSRCCRSQSKLSHGYAFCANQVTNRDSSYDECSSDDYVNKRWDRRRDLDESKAPKARGHNEGSTGTVTVDFYARQVCCRECG

Sequence clustering based on sequence similarity using MMseqs2