Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2e-16 7.6e-13 50.4 0.1 34 85 22 70 18 73 0.89

2 2 9.2 3.4e+04 -3.0 0.0 49 60 151 162 149 174 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2e-16	7.6e-13	50.4	0.1	34	85	22	70	18	73	0.89
2	2	9.2	3.4e+04	-3.0	0.0	49	60	151	162	149	174	0.82

Coding Sequence: ATGAAGGAAATCGAGATTAAGGAGGGAGATCCTGTGATTGAAATCGAAAACGGCGAAGATAGAGACCGGTTTCCATTCTACAAATCCAACGATGATCGATGGAAAAATTCAGTGCGGCACAATCTGTCAATCAATCCACATTTCAGGAAAGGCGTCAAAGCTCCACAAGGTGCCGGTCATTTATGGACAATTTCCAGTGGCGACTCTGAGGAAAACATCTTAGCCTGGGAACATAAAAAACAACGCCTtgacttatttttcaaaatggaaACAATGAACAGAGAGAGACTTGCACTATCACCTGGCGCTCGTGACCAAAACCATCAGGGTTACGACGAAGCGGCTATAGCTGCTGCCACCATAACTCAAGAAATGCAAACGTCCATGTCATCAGATCAATCTTCAACAAGCTGCTCACCCTCAACCTGCGATCGATTAGCCACCACATCAACATCAGTAACACATGAGCTGCCATTTAACGACCTCATGTCGGATGAAGATCTTCGTAAGACCGCTGGACAGATTCTAAATGGCATTCATCGGGAGGTCGAAGTTCAGGCGGTTAATTCAATCATCAGCACCTATCATGATAGTTTATTGGACTCAGAAGACTACTTAAATCCGATTCAAAAGGATGTATCGGTTCATGAAAGTGGACTACGCAATGACTTCTATGTGACAGAGATCGATCCAATTGAATTGGGCATACAGATGTCGCAAGTAGAAGAAGAAGTTCTATTCAATGatgaattcaatttgaattactTTGGTTACAATGCAGGAAATGATATAGTGGCTTGA
Protein Sequence: MKEIEIKEGDPVIEIENGEDRDRFPFYKSNDDRWKNSVRHNLSINPHFRKGVKAPQGAGHLWTISSGDSEENILAWEHKKQRLDLFFKMETMNRERLALSPGARDQNHQGYDEAAIAAATITQEMQTSMSSDQSSTSCSPSTCDRLATTSTSVTHELPFNDLMSDEDLRKTAGQILNGIHREVEVQAVNSIISTYHDSLLDSEDYLNPIQKDVSVHESGLRNDFYVTEIDPIELGIQMSQVEEEVLFNDEFNLNYFGYNAGNDIVA

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01521696; iTF_00688427; iTF_01300648; iTF_00724587; iTF_00893679; iTF_00665455; iTF_00664672; iTF_00334787; iTF_01253359; iTF_00241330; iTF_00312406; iTF_00313265;
90% Identity: iTF_01521696;
80% Identity: -