Vina034766.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Volucella inanis
Gene Symbol
pax6a
Assembly
GCA_907269105.1
Location
OU026158.1:40567099-40629721[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.5e-72 1.5e-68 229.5 0.6 1 125 28 152 28 152 0.99

Sequence Information

Coding Sequence
ATGATGTTAACTACAGAGCACATAATGCATGGCCATGCGACATCGGTTAGTCAAAGTGCACTTTTTGGTTGCTCAACAGCTGGTCATAGTGGTATTAATCAGCTGGGGGGTGTCTATGTTAATGGGCGCCCCCTACCCGATTCAACGCGgcaaaaaattgtcgaattagcCCACTCAGGCGCGAGACCATGTGATATTTCACGTATATTACAAGTATCGAATGGATGTGTTAGCAAAATTTTAGGCAGATACTATGAAACGGGATCAATTAAACCACGAGCAATTGGCGGTTCAAAGCCGCGTGTAGCCACAACGCCGGTGGTGCAAAAAATCGCCGATTACAAACGTGAATGCCCAAGTATCTTTGCGTGGGAAATTCGTGATAGATTGCTGTCGGAACAAGTCTGCAATAGCGACAATATACCAAGCGTTTCATCAATCAATCGGGTTCTTAGGAATTTGGCATCACAAAAAGAGCAACAAGCTCAACAGCAAAATGAATCTGTTTATGAAAAACTGCGTATGTTTAATGGGCAATCAGGTGGATGGGCGTGGTATCCTAGTAATGCACCACCAGCACATTTAGCCTTGCCACCGACACCAGCGGCTACAAGTCTAACAGGGCAAATCACCAGAGACGAATTGCAAAAACGTGATCTTTTTTCGGGGGATGTGTCACATCCGAATTCGCATGAAAGTACTTCAGATGGCAATTCGGATCACAATTCTTCTGGAGATGAAGACTCACAAATGCGTTTGCGTTTGAAACGAAAATTGCAGCGAAACCGAACATCGTTTACAAATGAGCAAATCGATAGTTTAGAAAAAGagTTTGAACGAACTCATTATCCAGACGTGTTTGCCAGAGAGAGATTAGCTGAAAAGATCGGTTTACCAGAGGCACGTATTCaggtTTGGTTTTCTAACCGACGCGCAAAGTGGCGACGGGAAGAAAAACTTCGTACCCAACGCCGTTCTGTAGATCATGTAACGAGTGGCAATGGATCTAGTGGAACAGGAACTACCGTTAGTGCAAATGGCGGCAATACTGGGTCTGGTGGTGGTTCAACAGCCAATGGATCGAACAACAATGTGGGAGAGAATGCAAATACAGGTGGAGGTGGTGGCACTAATGGTGGTAGTAATGGACCAGGTGGGACCAATTCAGATGGTAATCCCGGTGGGCATACAAACTCTGCTAGTCCACTATTGCAGGCAGTTGCTCCGCGCTTGCCACTGAATTCAGGTTTCAATTCAATGTACTCGTCTATTCCGCAGCCGATTGCAACAATGGCCGAAAATTATAGCTCTATGACGTCTTCACTTGGTTCGATGACTACTTCTTGTCTTCAACAGAGGGACAGCTATCCATATATGTTTCACGATCCGCTCTCATTAGGATCGCCATATGCAGCACATTCACGAACCCCATGCAATCCAGCTGCGGCCCACCAACAGCCGCCGCCACAACATTCAGCATACGGTGGTGGCGCTGCAGCAGCCAGTAGTACTGGTGTTATTTCAGCTGGAGTCTCTGTCCCCGTACAAATCCCATCGCAAGGAGCCGATCTCGGTACCAATTATTGGCCAAGGCTCCAGTGA
Protein Sequence
MMLTTEHIMHGHATSVSQSALFGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQSGGWAWYPSNAPPAHLALPPTPAATSLTGQITRDELQKRDLFSGDVSHPNSHESTSDGNSDHNSSGDEDSQMRLRLKRKLQRNRTSFTNEQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRTQRRSVDHVTSGNGSSGTGTTVSANGGNTGSGGGSTANGSNNNVGENANTGGGGGTNGGSNGPGGTNSDGNPGGHTNSASPLLQAVAPRLPLNSGFNSMYSSIPQPIATMAENYSSMTSSLGSMTTSCLQQRDSYPYMFHDPLSLGSPYAAHSRTPCNPAAAHQQPPPQHSAYGGGAAAASSTGVISAGVSVPVQIPSQGADLGTNYWPRLQ*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01521711; iTF_00314984; iTF_00315137; iTF_00324141; iTF_00324289; iTF_00334989; iTF_00427105; iTF_00334800; iTF_00426968; iTF_00976434; iTF_00976289; iTF_00663891; iTF_00664012; iTF_00670899; iTF_00670786; iTF_01541267; iTF_01541387; iTF_00665589; iTF_00665539; iTF_01211736; iTF_01211895; iTF_00688441; iTF_00688613; iTF_01300665; iTF_01300837; iTF_00310202; iTF_00310074; iTF_00974620; iTF_00974476; iTF_00671454; iTF_00671546; iTF_00984190; iTF_00984116; iTF_01049617; iTF_01049485; iTF_01382033; iTF_01381924; iTF_00245234; iTF_00245354; iTF_00315923; iTF_00315777; iTF_00312564; iTF_00312426; iTF_00013845; iTF_00013963; iTF_01375765; iTF_01375557; iTF_00351703; iTF_00351812; iTF_00352378; iTF_00352468; iTF_01522395; iTF_01522598; iTF_00724605; iTF_00724746; iTF_01542013; iTF_01542157; iTF_00793472; iTF_00793366;
90% Identity
iTF_01521711; iTF_00665539; iTF_00974476; iTF_00665589; iTF_00974620; iTF_00314984; iTF_00315137; iTF_00334989; iTF_00427105; iTF_00334800; iTF_00426968; iTF_00670899; iTF_00670786; iTF_01211736; iTF_01211895; iTF_00310202; iTF_00310074; iTF_00311643; iTF_00311770; iTF_00724605; iTF_00724746; iTF_00671454; iTF_00671546; iTF_00976434; iTF_00976289; iTF_00315923; iTF_00315777; iTF_00663891; iTF_00664012; iTF_01541267; iTF_01541387; iTF_00312564; iTF_00312426; iTF_01300665; iTF_01300837; iTF_01522395; iTF_01522598; iTF_01542013; iTF_01542157;
80% Identity
iTF_01521711;