Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00056 18 7.9 0.0 10 45 41 76 37 79 0.90

2 5 5.2e-07 0.017 17.6 0.1 21 48 80 107 77 111 0.92

3 5 0.014 4.5e+02 3.4 0.0 21 44 137 160 132 165 0.87

4 5 0.00014 4.6 9.8 0.2 18 48 180 210 174 213 0.89

5 5 0.11 3.7e+03 0.5 0.1 23 37 240 254 236 264 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00056	18	7.9	0.0	10	45	41	76	37	79	0.90
2	5	5.2e-07	0.017	17.6	0.1	21	48	80	107	77	111	0.92
3	5	0.014	4.5e+02	3.4	0.0	21	44	137	160	132	165	0.87
4	5	0.00014	4.6	9.8	0.2	18	48	180	210	174	213	0.89
5	5	0.11	3.7e+03	0.5	0.1	23	37	240	254	236	264	0.80

Coding Sequence: atgagTACGAGTGGTTTAAAAAGGTCTGACTCTAAAGACGATGCAAGCAGTTCATTGCGAGACAGTGGAATATCAATATTTGAAGGACTGTCGGAAAGTGAACTAGAAAGCAGTAAAACTTCGGGTAGTAAGAAGACAGCAAGACGATCAATTACTGCTAAAAATTATGAATGCGCCGTTTGTGGGAAAAAATTTGGTGGTAGTACTGATCTGCGACGTCATCTTCTAATTCATTCCGACGAGAAACCGTACACATGTGGAATATGTCAGAAATCCTATAGGCAAGAAGTGAATTTGAAAAATCATATGAAAATAGCACACACCAATCAGAGAGAGTTTATGTGTTCTTTTTGTCGAAGGCCATTTCCATTAAAACAGagattaaaatttcatttacgcATTCATACCGGAGAGAAGCCTTATTCTTGTCCAAAATGTGCTAAAACTTTTGCCCGAGGGGGACAACTTCAGCAGCATTTGGCTACTCACGACAAGATAAGCAAGAAATTGTCTGATATATGTCGTTCTACATTCTCAAATGAGAAAAATGAGCGTAGTAATAAGTGTCAGATATGTAACCAACTATTTTCAACTGACAAAAGTATGCGAGTGCATTTGAAATTGAAACATgcaaaaataaaggaatttcAATGTCAATTATGTGACAAAACTGTTAAAGATGACATAGAAAATCATATGAAACTTCATACTCCGACTAAGCCGTTTGAATGTGAAATATGTAAGGCTGCTTTTGCACAAAAGGGACAGTATAACATACATCAAAGGACGCATACAGGAGAACGACCATATCAGTGCAGAGTAAGTAAACataagattttttatttgaaaaaacgcGATTTTCTAACTTATAAATATTATTGCAAATTCAATATCTATGTAAGTCTCACGATCTATTTCTCTACCTTGGTGATACAAGCGTATATTGAACACAATAGGTTTCTGGAAATAGATTAA
Protein Sequence: MSTSGLKRSDSKDDASSSLRDSGISIFEGLSESELESSKTSGSKKTARRSITAKNYECAVCGKKFGGSTDLRRHLLIHSDEKPYTCGICQKSYRQEVNLKNHMKIAHTNQREFMCSFCRRPFPLKQRLKFHLRIHTGEKPYSCPKCAKTFARGGQLQQHLATHDKISKKLSDICRSTFSNEKNERSNKCQICNQLFSTDKSMRVHLKLKHAKIKEFQCQLCDKTVKDDIENHMKLHTPTKPFECEICKAAFAQKGQYNIHQRTHTGERPYQCRVSKHKIFYLKKRDFLTYKYYCKFNIYVSLTIYFSTLVIQAYIEHNRFLEID

Sequence clustering based on sequence similarity using MMseqs2