Vger007265.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Vespula germanica
Gene Symbol
PAX6
Assembly
GCA_905340365.1
Location
HG996536.1:7563302-7580873[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 8e-31 1.1e-27 96.1 0.0 61 125 266 331 245 331 0.94

Sequence Information

Coding Sequence
ATGATGATCGGTGGTGGCGTCGCGAGCCCTCCTGGTACTGCCAAGTCGGTGGCTGCGATCGACGGCGAGATGGTGCAGGTCGAGGGCATTGGCAGTGGAAGTGTCAGTGGCAGTgctagtggtagtggtagccCAGCGACCGCTTCTACGCGACTACCAAATAACACCAACGCCAACGGCagtagcaataataataataataataataataatagtaataataataataataatagcagtagtagtagtaataataataataataatagtaataacgcGAATCCGAATTCAAACGCGAGCAATAGCGGTGGCAACGGCAACAACGGGAGCAACAATAACGGCCAGGGCGGGGGGGACGTAAGtagcaacaataataataatgacggaCACGCGGTGCTGAATTGCAGCGGCGCCGGCAGCGCCGCAAGTGACAAGTTTTGCTGTCACGACGAGGACGTTCCTGTGAGCACGGCAGTAGCGCGACCTTGGGAACCACCCTCGCCGACCTTCTCGCAGACGAGGTCGCACCTTCTTCAGGTTCATCCGACTCATCATCATCAGCATCCGGCTGCTCATCCTCATCAACAAATGACCGTACCGCCGGCTTCCCTTATCGACGGCGTGAGCTTGCAGAGCTGTACAGCGGGACCATTTGCGAGCGGTAATGGCGGTGGTGCATCGCGGCAACGTTTGCTGGAACTGTCGCACGGATTGGGAGCTCTTAGACATTACAACGACCTAGCCAATCACGTGTTATCCCTCAACCAACAGGGTGCTGTCGTCACAAAACTTTTAGGTACGCTACGTCCGCCGGGCCTGATCGGTGGAAGTAAACCCAAAGTTGCGACGCCCGCTGTAGTTGCCAAGATCGAGcaatacaaaagagaaaatcctACGATATTCGCGTgggaaataagagaaagactCATATCCGAAGGTGTGTGCAGTAACGCGACGGCACCGTCGGTGAGCAGTATCAATCGAATTTTAAGAAATAGAGCTGCTGAGAGAGCTGCCGCGGAATTTGCGAGAGCAGCAGGTTATGGATTGTATGCGGCCGGGCCGCATCCATATTTTAATTCGGCTGCTGCAGCAGCTGCAGCTGCTCATCAGCATCCAACGACGAGTCATCATCTTCCAAGCGGATGGCCGGCTCCAGGAGCTGCTGGACACCCCTGGATGCTGCCACCCTTGGCCACTGGTATCTCGGGGGCGGCTTCGGCTTTGCTCTTACCACCATCCTTGAGTCCTGGTGCCGCAGCCGCTGCGGCCGCTGCCGCATCGGCCTCCGCTGCTGGTACCGCCGATCATGCTTTGCACGCTGCCGACGCCATCGCGAGAGGATACTTGCAAGATGGTGACGGTGACGACGGAAGTTTGGACGGTTCCGAGCAGCCAAAGTTCCGGCGAAATCGCACCACCTTCAGTCCGGAGCAGCTCGAGGAACTCGAGAAGGAGTTCGAGAGGTCGCACTACCCTTGCGTGTCGACGCGCGAACGGTTGGCTTCGAAGACCTCCCTCTCGGAGGCACGCGTACAGGTTTGGTTTTCCAACAGACGGGCAAAGTGGCGTCGTCATCAGCGAATGAACCTCTTAAAGCGTtcgccaccaccgccgccgccgccgccgccgccgccaccgccgccgcagCCGCGGCCGCACTCCGCGTCCAGCATGGAAATCGGCCGTACGTCGGGCTGCTCAATCGCAGGAATGGGAGGCGAAAGTAGCGCGTTTCGTGCGGTCGTTACGACTTCGTCGCAATCTTCGAGGGAGTCTAACGAGAGGATTGGTGGTAGGCTCGAATCGATTTCGAAACAgcaacaacatcaacaacaccaacaacagcaacaacaacaacaacagcagcagcagcagcagcagcaacagcaacagcaacaacaacaaacagaaaagaaaccaAGCGCTTTTCGTATGATCAGTCAGCTGGTTGGCGAAGATTCGCGTTCGAATTTGTCACGAGCTACGAGTCCCACCTACGAGATTCAAAGATCTGGTCATGGACCTGGTGGACCTGGTTCCGGTCAAAGAATGGACTATGAGACCGTcgaggacgaagacgaggacgaagaaatCGACGTACAAGATTCCGATCAAGATGTCCCATCTTCGCCGCCGGTCGCGTGGAGAGATCATTGGACCGATCAGCAACCTCTCGAATTGACCAAACACGATCGTTGA
Protein Sequence
MMIGGGVASPPGTAKSVAAIDGEMVQVEGIGSGSVSGSASGSGSPATASTRLPNNTNANGSSNNNNNNNNNSNNNNNNSSSSSNNNNNNSNNANPNSNASNSGGNGNNGSNNNGQGGGDVSSNNNNNDGHAVLNCSGAGSAASDKFCCHDEDVPVSTAVARPWEPPSPTFSQTRSHLLQVHPTHHHQHPAAHPHQQMTVPPASLIDGVSLQSCTAGPFASGNGGGASRQRLLELSHGLGALRHYNDLANHVLSLNQQGAVVTKLLGTLRPPGLIGGSKPKVATPAVVAKIEQYKRENPTIFAWEIRERLISEGVCSNATAPSVSSINRILRNRAAERAAAEFARAAGYGLYAAGPHPYFNSAAAAAAAAHQHPTTSHHLPSGWPAPGAAGHPWMLPPLATGISGAASALLLPPSLSPGAAAAAAAAASASAAGTADHALHAADAIARGYLQDGDGDDGSLDGSEQPKFRRNRTTFSPEQLEELEKEFERSHYPCVSTRERLASKTSLSEARVQVWFSNRRAKWRRHQRMNLLKRSPPPPPPPPPPPPPPQPRPHSASSMEIGRTSGCSIAGMGGESSAFRAVVTTSSQSSRESNERIGGRLESISKQQQHQQHQQQQQQQQQQQQQQQQQQQQQQQTEKKPSAFRMISQLVGEDSRSNLSRATSPTYEIQRSGHGPGGPGSGQRMDYETVEDEDEDEEIDVQDSDQDVPSSPPVAWRDHWTDQQPLELTKHDR*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01513989; iTF_01514663; iTF_01513300; iTF_01514777; iTF_01514106; iTF_01233604; iTF_01233474; iTF_01232249; iTF_01232359; iTF_01234297; iTF_01234178; iTF_01089822; iTF_01089948; iTF_01234976; iTF_01234851; iTF_01232953; iTF_01232839;
90% Identity
iTF_01513300;
80% Identity
iTF_01513300;