Basic Information

Insect: Udea ferrugalis
Gene Symbol: PAX6
Assembly: GCA_950022985.1
Location: OX465523.1:8302354-8330448[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 8.1e-35 1.5e-31 109.8 0.0 23 125 53 150 42 150 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	8.1e-35	1.5e-31	109.8	0.0	23	125	53	150	42	150	0.92

Sequence Information

Coding Sequence: ATGTTCTTGCGCGCTTCCCTTCGCATCACTTTGCATGTTAAGCGCGCGCGCAGGTTGCCTGTATCTCCTTCATCATCGGGGGGTGGCGCCACCGGCGGAGGGACGACCTCGCTCTACCCTGGCGCGGCGTCTCATCCCCTCTCGTCACTCCTGTCGCAGCAAAGGCTTCTGGAGTTGTCAAGGTTCGGCCTGAGGCACTATGACATCGCGCACCACGTCCTGTCTCAGCAAGGTGCTGTTACTAAACTGCTTGGCACTCTACGACCTCCAGGCCTCATCGGTGGCAGCAAGCCCAAGGTGGCCACGCCGGCAGTCGTGTCCAAGATAGAACAATACAAGAGAGAGAACCCCACCATCTTTGCCTGGGAAATTCGAGAAAGACTGATTTCTGAAGGTGTTTGCACCAATGCAACAGCCCCAAGTGTGTCATCAATCAACAGGATCTTGCGGAATCGGGCAGCTGAGCGAGCGGCAGCGGAGTTCGCCAGGGCGGCAGGTTACGGTCTCTACGCCGCTCCGCCGCCCTACGGAGCCTTCCCCTGGGCCGGGGGCGGGGGCGTCTGGCCTCCTGGAGGCCTGCCTCTTCCCCCTGGAGTGCCAGGGCCACCATCCGGCGTGCCGCACCCTGACATGCAGCAGGGTTTCCTCTCGTCATCTGGACGCGGGCTCATAGACGTGGACGGCGACGATTCCGGATCGTTAGATGGAGAGCAACCCAAGTTCCGACGGAACCGCACCACCTTCAGCCCTGATCAGCTCGAAGAGTTAGAAAAGGAATTCGAAAAATCTCATTACCCATGCGTGTCCACTCGAGAAAGGCTCGCATCTAAAACGTCGCTGTCGGAAGCACGGGTCCAGGTTTGGTTTTCCAACAGACGAGCCAAGTGGAGACGCCATCAGCGCATGAACCTCTTGAAGCGAGGTGGCGGCTCGCCCCCGCACCGCCTCCCCCACTCCCCCTCTCGTTCCCGATCTCGTTCTTCGTCCCCCTCACGTTTCCCTTATCATACTCCTCAAATGGGCGGCGAAAATAGCGCATTTAAATCGCTCGCACACCAAGAGAGTAACGCACTGAAAGCTTTGTCGCACCAAGCGCAGTTCGACAGCAACGCACTGAAAGCACTATCTCAGCAGCAGTTTGACGGGGATGCGTTTAAGCATCACCCGGCTTTAGAAAACAGCGCGTTTAAAGCGCTTGTTCCGCACTCAGCGGCTGCAGCGCTTTTGGCGGCGCAATCCATACAGTTAGCTCGTGGCTATGAGTCCCACTCGGATTCTGACGAGGAGATAAACGTCCATGACGAAAGCGACGATGAAAGTGAGAGACAGAAAACCAAAGGCAGGTCCCGGACGCCGAGCCCCAGCCGACATCGCGCGCCAGCCAACGACTTGCCTCTCCAACTCACCAAACACGACCGCTGA
Protein Sequence: MFLRASLRITLHVKRARRLPVSPSSSGGGATGGGTTSLYPGAASHPLSSLLSQQRLLELSRFGLRHYDIAHHVLSQQGAVTKLLGTLRPPGLIGGSKPKVATPAVVSKIEQYKRENPTIFAWEIRERLISEGVCTNATAPSVSSINRILRNRAAERAAAEFARAAGYGLYAAPPPYGAFPWAGGGGVWPPGGLPLPPGVPGPPSGVPHPDMQQGFLSSSGRGLIDVDGDDSGSLDGEQPKFRRNRTTFSPDQLEELEKEFEKSHYPCVSTRERLASKTSLSEARVQVWFSNRRAKWRRHQRMNLLKRGGGSPPHRLPHSPSRSRSRSSSPSRFPYHTPQMGGENSAFKSLAHQESNALKALSHQAQFDSNALKALSQQQFDGDAFKHHPALENSAFKALVPHSAAAALLAAQSIQLARGYESHSDSDEEINVHDESDDESERQKTKGRSRTPSPSRHRAPANDLPLQLTKHDR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00660136;
90% Identity: iTF_00447992;
80% Identity: iTF_01502798;