Basic Information

Gene Symbol
znf423
Assembly
GCA_949699805.1
Location
OX453041.1:18118969-18132046[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 21 9.4e-06 0.0012 19.9 1.5 1 23 68 90 68 90 0.98
2 21 0.37 47 5.5 4.0 1 23 96 118 96 118 0.97
3 21 1.2e-06 0.00016 22.7 4.1 1 23 124 146 124 146 0.99
4 21 0.00025 0.032 15.5 0.2 1 23 152 174 152 174 0.99
5 21 0.0016 0.21 12.9 0.6 1 23 335 358 335 358 0.96
6 21 0.07 9.1 7.8 0.1 2 23 369 391 368 391 0.92
7 21 0.23 30 6.1 0.1 3 23 461 481 460 481 0.97
8 21 0.02 2.5 9.5 0.0 3 23 497 517 496 517 0.96
9 21 0.0029 0.38 12.1 0.5 1 23 526 549 526 549 0.92
10 21 4.2 5.4e+02 2.2 0.2 1 23 554 577 554 577 0.91
11 21 4.7 6e+02 2.0 0.1 10 23 609 623 608 623 0.95
12 21 0.8 1e+02 4.4 2.1 2 23 651 672 650 672 0.96
13 21 0.0067 0.87 11.0 0.1 1 23 677 700 677 701 0.94
14 21 6 7.7e+02 1.7 0.3 3 23 770 792 768 792 0.80
15 21 0.00014 0.019 16.2 1.3 2 23 808 830 807 830 0.96
16 21 1.3 1.7e+02 3.8 0.7 1 12 839 850 839 862 0.76
17 21 2.9 3.8e+02 2.7 0.2 5 23 873 891 869 891 0.92
18 21 0.0062 0.8 11.1 0.2 2 23 1077 1099 1076 1099 0.95
19 21 0.053 6.8 8.1 0.3 1 23 1109 1132 1109 1132 0.96
20 21 0.0045 0.58 11.5 0.1 2 23 1175 1197 1174 1197 0.94
21 21 0.61 79 4.8 1.7 1 23 1204 1227 1204 1227 0.93

Sequence Information

Coding Sequence
ATGCAACCTGACCATTCGGACGGCGATGCTTTGGGCACCGGCAGTTCATCTTGGCACAGCGAAGATGGTGGCACAAATTCTCGTCGGGGCGGAGAAACGCCGTCGTCCTGTGCGACTCCAACGTCCGCAAGTTTTCCATCGGAACCAGAGGTTGACACCGAAGTTGGTGTCAATGCCGACGGAAACAATCCTGCCGCACCATATCCGTGTCAATTTTGCGACAGGACATTTCCCAGGCTTAGCTACTTGAAGAAACATGAACAGAGTCATGGTGATCAAATGCCGTACCGTTGCAACTGGTGCGCTAGGCTTTTCAAGCATAAACGCAGCAGGGATCGCCACGTCAAGCTGCACACCGGAGACAGAAGATATCGGTGCTCCCATTGCGAGGCTGCCTTCTCCAGAAGTGATCACTTGAAGATCCACATGAAAACTCACGACAACCAAAAGCCTTATCAGTGCACAGCGTGTTCGCGTGGTTACAACACAGCGGCAGCTCTGACATCGCACATGCAGTCGCACAAAAAGCATCAGAGTCCAGGCCAAGCGACTAAATTAGAGATGGATTACGGTCGTCGAAGTGTATCATCGCACAGTACATCATCACCGCCAATCGGAAACTCTCCATCACCAAGTTTGAATCTAAGCTTACATCCAAAAAGTTCATTAAAATCGAGTTACCTAAACAGCAACGGTACCTCAAACGCCCCGCTAGTAAATTCCCCGTTAAAACTCGCGTGTATGTATTGCACGAGAGATTCATTCACGAGTATGCAACAGTTGCAGATGCACGTTCACGCGATGCATCAAGCGATTTTAAACGGTGAAAGTTTGACGATGACTTCACCGCCGCGAAATCAATTAGACGGTAAAAGTTACGTTAAATCTCAGGATCAcgaaaagggggaaaaaaacagTAGAAAAGACTACGAAATGGCGTATCGCCTCGAAGATCCAGAAAAACCCGTGGAAAGAGTCAAAGGAGATTTGTCTGATAGCGAATTTAGCTGCGGTCAATGtacaatgaaattttcaaacgtTACTTCCCTAAGAGATCATTTACTGTCGATACACCGAAATGACGGATTCGCTTCCGGTTTGATGATGTGTCCTCTGTGCGGAATTCCGTGCACATCAGCCGCCGCTTATGCAGAACATTATTTGCTTCGACATTGCGAGAATCGTCGGTTAACATCGAAAGATCCCAATCGTCGGGATTGGGAGGAAACTACGGCAAATGGAATACACGAGGAAAATCAGCCGTCCTCAAAAAATCAAGGTTTTATCGGCAGATCCGACGTCGCTTCGTCGGAACCTGCGGATTTAACGAAAAAACATTCAAGACCCGGAGACTCGAGTTATTCGGCGGGTACTTTGCTCTGTGGTCAATGCGGCGCCGCTCTCAAAGACTTTGAATCATTCCGCGAACATTTAGCCAGACACTTGCAGGCTGATCAACAAAACAGCGAAATCGTGCCGCGAAATCCTTGCCCAAAGTGCGACGCTAATTTTCCAGAACGCGAGGACATGTTGGCTCATCTAACGAAGCACTATCTTGGACAGATGACCAAAGAATACGCGTGCGGTGcttgcaaaaaattttatccGCATCCGGATCTTTTGCAGCGGCATCTTCTCGACACTCACGCTCATCATCTCTACAGATGCGCGTTATGTCGAGATACTTTTGACTCCAGAGTCGCTATACAAGTTCATTTCGCTGTTAAGCACAGCCAAGAGTGTCGCATTTATCGGTGCAGCACTTGCAGCGCTTCCAACAATGAAAATTCACCAGGTAACAGCTCCGGGGAAGGCAGAAGCTACTTTAGAAGCGAAAGCGAAATGGCGAATCACGTTAGGACCGTTCACGCTCCGCCAAATTCACTCGCCAATGAAGGACCTTCCCCCAAAAGTCGGGCTTCCACTCCTGGTCCTAATGTTGCCAATACTAGGTGCGTTTTCTGCGGAATCTGCTGCAATTCCGATCTCGAATTGCAACTTCATCTTGCTAGCCATTCCAGCAGCTTGTATCGATGTCCTATATGCAGAGAAGGATTTCCCGTGGAATTTTTACTCGACAGGCATATTGCCCAAGCACATCATACCAATAGCGACAGGAGTGATGCTGGAGAAAATGGAAGGACACACAGAACCTCGCGATTGGGAGAGGAAACGACGCGACCCCAAAAGCGAGGAAGATCGCCAGCATCGAGCAACAACAATTCCCTGAACCAGCGCGACAATAACAACAAGAGACTAAATTACGGCGCGACAAATGGCGCAACCATGGTGCGAGGTGGTCAGCGATGCGAGCTCTGTGAGCACGGCGAATTCGCGACAGAAGCTGAATTACAGGCGCACAAAAAATTGGTCCACACGCCGGTTAAGCTGCAGGCCAAGTCGTTGTCGTCGCTCAGCATGACATGTGCTTACTGCGGCGAGATTTGTCGTTCGCGAAGCGAGCTCGAGTCTCACACGAGAATGCAGCACGCTTCTAACGAGCCGGGCGGACGTCACAAGTGCAACATTTGCGACGAGGTTTGTCCATCGGGTGGAATATTGGCCGAGCACAAGCTTCAGAAACATTGCAAAATTCAGTTGAGTGACAATTGCATTGTTTGCCGTACAACCCTCACGAGTGAGGCTCAATTTATAGAACATGTGCAGCGTCACAGTCTTGAAAATGCGGATCCTCAGCAGCGAATTGAAAATGCGCTTCCTCATCTTCCGGCAGGTTGCGTTGTCTGTCGACAGACTCTAATAAGCGATCTCGAGTGCCGATTGCACGCGAGACATCATCTCCGAGCTTCCACTAGCTTACAGAGCTTAAATTCCAGTCCGAGTCCAGTTCACAAGAGCCAACAACAACCGCAACAGCAGCCTCAACAGCACCAACCAATTCAACGTCCAACGCTAAGCTGTTGTCTCTGTTTGAGGGAATTTACCGCCGATGATTTCGTCAGTCTTCCGTCGAATCCCTCAGGAACCGCTGGACCTTCTCTGAGAGTCTGCAAACCTTGCTACGTCCGACATTCGCAAGGACTACCGATTCTCAGCTCGCCTTATGAACACGTCAGGCCGTCCAAGAGTGAAACTTTGATGTGGCCCGCTGCCAAAGATCAGGCCAATTGGGAAAGCTCCAGAGATCGTTGGGATAATGAAAGATGCTACAAAACCGATGACAGTGGAATTGGAAAAACGGGAATCGAGGATAATTCCGATGAAAAAAGGTGCGAGGAGTGCGGaattaaattcgaaaattccgaaGAAGCGGAGAGTCACAGGATCAAGGAACACGAGAATAATTGCGGAAATGCCAACATCTATACTTGCATACAGTGCCAGATTTCCTTCCCAACCGAAGATAAAATTCAACAGCACGTGAGAAAAGAACACTTGGAATCGCCGAACCAAGCTTCTATAGAGGCACTGCGATGCCATCTCTGTCTTTTTGAAGGCAACAGTCCCCTTCAACTTCAAGGACACTTAATAGAGCATACATTCGCTGGATGCGCTGGTCTCACTTGCTATATATGCCAGGCACTTTTTACTACCCCTATCGCGCTGCAGAATCACATGCTTCAACAGCATGGGCTGGGCGCTCGTCCCTACGATTGCAGTAATTGCAGCCTGAAATTCTTCTTCCGCGTCGAATTGGACCATCACACAGTAATGGTACATCGAAGAACGGCAACATCTTCGCCGCCCGTAGACGTAGGACAGGAAACTACGATGGAAAAGCGAGAAAAACTGACGGATAATAGAGCCGCCGACGAAAATCAGCACCGTTTGGAAAATATTACAGTGAAAGAAGAGATAGCGAATAGTTTGGAAGACGAGGATGTCAACGTGGACGGCCACATCGACCAGCCAACGGATCCCGAGTCAAAGCATGAATCGTGTCCTTTGGTAGACGCTAAAAAAGAGCCGTTCACTGTACCACTTTCGATGGAAGAGAAACCCGTCTCCTGA
Protein Sequence
MQPDHSDGDALGTGSSSWHSEDGGTNSRRGGETPSSCATPTSASFPSEPEVDTEVGVNADGNNPAAPYPCQFCDRTFPRLSYLKKHEQSHGDQMPYRCNWCARLFKHKRSRDRHVKLHTGDRRYRCSHCEAAFSRSDHLKIHMKTHDNQKPYQCTACSRGYNTAAALTSHMQSHKKHQSPGQATKLEMDYGRRSVSSHSTSSPPIGNSPSPSLNLSLHPKSSLKSSYLNSNGTSNAPLVNSPLKLACMYCTRDSFTSMQQLQMHVHAMHQAILNGESLTMTSPPRNQLDGKSYVKSQDHEKGEKNSRKDYEMAYRLEDPEKPVERVKGDLSDSEFSCGQCTMKFSNVTSLRDHLLSIHRNDGFASGLMMCPLCGIPCTSAAAYAEHYLLRHCENRRLTSKDPNRRDWEETTANGIHEENQPSSKNQGFIGRSDVASSEPADLTKKHSRPGDSSYSAGTLLCGQCGAALKDFESFREHLARHLQADQQNSEIVPRNPCPKCDANFPEREDMLAHLTKHYLGQMTKEYACGACKKFYPHPDLLQRHLLDTHAHHLYRCALCRDTFDSRVAIQVHFAVKHSQECRIYRCSTCSASNNENSPGNSSGEGRSYFRSESEMANHVRTVHAPPNSLANEGPSPKSRASTPGPNVANTRCVFCGICCNSDLELQLHLASHSSSLYRCPICREGFPVEFLLDRHIAQAHHTNSDRSDAGENGRTHRTSRLGEETTRPQKRGRSPASSNNNSLNQRDNNNKRLNYGATNGATMVRGGQRCELCEHGEFATEAELQAHKKLVHTPVKLQAKSLSSLSMTCAYCGEICRSRSELESHTRMQHASNEPGGRHKCNICDEVCPSGGILAEHKLQKHCKIQLSDNCIVCRTTLTSEAQFIEHVQRHSLENADPQQRIENALPHLPAGCVVCRQTLISDLECRLHARHHLRASTSLQSLNSSPSPVHKSQQQPQQQPQQHQPIQRPTLSCCLCLREFTADDFVSLPSNPSGTAGPSLRVCKPCYVRHSQGLPILSSPYEHVRPSKSETLMWPAAKDQANWESSRDRWDNERCYKTDDSGIGKTGIEDNSDEKRCEECGIKFENSEEAESHRIKEHENNCGNANIYTCIQCQISFPTEDKIQQHVRKEHLESPNQASIEALRCHLCLFEGNSPLQLQGHLIEHTFAGCAGLTCYICQALFTTPIALQNHMLQQHGLGARPYDCSNCSLKFFFRVELDHHTVMVHRRTATSSPPVDVGQETTMEKREKLTDNRAADENQHRLENITVKEEIANSLEDEDVNVDGHIDQPTDPESKHESCPLVDAKKEPFTVPLSMEEKPVS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00343389;
90% Identity
iTF_00343389; iTF_00653088;
80% Identity
-