Basic Information

Gene Symbol
-
Assembly
GCA_949699805.1
Location
OX453043.1:14651084-14657760[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.049 6.3 8.2 0.2 3 21 8 27 6 28 0.85
2 14 1.6 2.1e+02 3.5 0.0 2 20 34 52 33 53 0.93
3 14 0.81 1e+02 4.4 0.3 1 12 231 242 231 251 0.89
4 14 0.11 15 7.1 2.2 1 20 396 415 396 416 0.95
5 14 0.00025 0.033 15.4 0.9 1 23 421 443 421 443 0.98
6 14 1.3e-05 0.0016 19.5 1.2 1 23 456 478 456 478 0.98
7 14 0.066 8.5 7.8 0.5 1 23 497 518 497 518 0.91
8 14 0.00056 0.072 14.4 0.1 2 23 524 545 523 545 0.95
9 14 5.5e-05 0.0071 17.5 4.8 1 23 611 633 611 633 0.99
10 14 2.4e-06 0.00031 21.8 3.7 1 23 639 661 639 661 0.96
11 14 0.00028 0.035 15.3 4.1 1 23 667 689 667 689 0.97
12 14 1.1e-06 0.00015 22.8 0.9 1 23 695 717 695 717 0.98
13 14 0.00011 0.014 16.6 0.2 1 23 721 743 721 743 0.99
14 14 0.00023 0.029 15.6 0.1 1 23 751 773 751 773 0.98

Sequence Information

Coding Sequence
ATGGGTTCTCTGAGCCTCGTATGTCCCATGTGTTGCGGAGAGACATTCGACGACTCTCAGTCGTTGAAATATCATTTGCTCAGCATGACGGACAATCTTTATTGTCCCAACTGCGCTGATCGTTTTGATTCTGTCGCTTCGTTGATTCGTCATCTGGATTGTTGTGGTcaaaacgctgaaaaaaaatgcactgcGCAAGCTGAAGATAAAAAAGAACAGTGCAACGTCATTTTGgagaaaaatgaaatgGATAAATTGGACCATGAATTTCTGGCCACCGTGGACGAAAATGGTATCATCATTGTTGAAGGATCGCGATCTATGGAAATGGATGAAAATGgggatattcaagttaaaaataaatcggaGCCAGAAAGTCACGAGATTTTAGGAACTCTGGACATCCCGCATGattctgaaaaagaaaaaagtaccgGGGAAATGACGCACCGAATTGAGGATCGTACCGATATCAATCAGTCGCCCGTAAAGGTCGAAAAAAGCGTAATTGCAATGCTGGAGGACGATTCAGAGGAATTCATCGGACCAGAGAATGACGAACGAATCGATGCCAACAACTCGAGTCCCATGGTGGGAATTGAGCGATTAGATGATCAAGTTGAGGAACTCGAAGACACTGGACTTCTTCGGGTGAAACAGGAAGTATGCGAGGAAGAATCTGAGGCACTGTTCAGTTGCAGTAGTTGTGGTATGAGTTTTAATAGTGTACTCGAGCATATTAAAGAGTATCACGACGGTCAAGAAGTGGTGCTCGAAATGGCTGAACAGCAAATGGACGAATTACCGCAAGAAGAGTCGTCGTGTATTGCAAATGTCGCGGAGGAAAGCTCGAGCATTTTGGCAACTGCAAATCGCTCCGTTGACATGAAAATTGACATGGAAACTGCGAGTGTTCCTACTCGTCAGCGTCAGACGATGAATACATTACGAACCGAAGAATGCGTCGATAGCGAGGGTCGACTTTACACAAGAAAAGTCGTGCAAATCGAGCGATTTTGGGATCGCGGTCCCGTAGCCGTTTCGCAATTGCAACTTCAGCAACATCAACAAGCGACAAAAAGCGGGCcgatgattgaaaaatttttctctAACGTCGAAGGCGTTAAAGTTCGCTCCAAAAGTCCGCCGAAACTCATTAATTCGTCCAGTGCTTCTCCACGGACGTACAGATGCAAAAGGTGCCTCGAACAATTTTCTAAACTCGATGATTTTCGCGTTCACGTCTGTCCCGATGGTAATCATAAATGCGAGCTCTGTGATCGAACGTTCGCGAGCGGAAAAGCTCTTCAGTTACACTCGCGCATTCACGACGGTGAAAACGAACAGAGGGAAAGtcacaaaaatttcatttgccCGACTTGCGGAACGCAATTTTCATCTCGTAAGAGTTTAAGACTTCACTCGCGAATGCACGCGCCTGTGAGAGCGAGACACGTCGATGCACCGGAAGGAACTGCAAATGGCAATTTCACGTGCCTCGAGTGTGgtaaaacGCTCTCGGAATCTTACAGAAAAGCGCACTTGTCACTTCACATGGGTGATTCTGTAACCTGCTCAGTTTGCAATCGTAAATTCGATTCATCAGACAGTCTCGCGATGCACGCTGCGGTGCATATCGAACTCGGCCAatcgcagcagcagcaacaacagcaacagcagcaacaacaacaaatccCTCCGGTTTctcaacaacagcaacagcagcaacaacaaatAACGTCCACAAAACAGGGACAAGAAGAGTCGAGTCAAGCGGCGCCGAAAACGGGAGAAAACGCTGGAGAAAACGTTCAGGATCCGCAAAAACCTTATCAGTGTCAACACTGCGGAAGGAGATTCACGAGACCTCACGAAAAGGTGAAACACGAGAGAATACACACGGGGGAAAAACCACACGCTTGTGAGGTATGCGGAAAGACGTTCCGAGTATCATATTGTCTAACCCTGCACATGAGAACGCACACGGGAGTGCGACCGTACGCTTGTCAGCACTGCGGCAAAAGATTCAAGGCCTCGTCGGTGTACAATCACCATTTATTGACCCACGGCGAAGAGCGCGCGTACAAATGTCCATATTGTCCAAAAACTTTCAAGACGAGAGTGCAATTGGCCGGACACAAGAACAGCCACACGAAGCCTTTCCGTTGCACAGAATGTTCTCGTCCGTTCGCCTCACTTTACGCAGCCCGCGCTCATATTCAGACTCACAAAAAGGACAACAATTTCAAGTTCAGCTGTTACATATGTGGCGCGTCTTACGGACGAGCTTTTGCTCTAAAAGATCATCTCAAAGTTCATGCTGTGCAAGACACTCGTGAAGCACCAGAACCGGCGCGTGAAGAGGAAGTAGCCGAAGCTGAAGATTATCTTATTAGCGAAGAGGTCGACGATTTGGAGGAACTCGAGGAAATAGACGACGAAGAGGGACAACTCGTAACAGCCGCTGTTACAGCCTCGGCATCTGCTTCCTCCGTAATTCTTCATCGACAGTCCGAATGA
Protein Sequence
MGSLSLVCPMCCGETFDDSQSLKYHLLSMTDNLYCPNCADRFDSVASLIRHLDCCGQNAEKKCTAQAEDKKEQCNVILEKNEMDKLDHEFLATVDENGIIIVEGSRSMEMDENGDIQVKNKSEPESHEILGTLDIPHDSEKEKSTGEMTHRIEDRTDINQSPVKVEKSVIAMLEDDSEEFIGPENDERIDANNSSPMVGIERLDDQVEELEDTGLLRVKQEVCEEESEALFSCSSCGMSFNSVLEHIKEYHDGQEVVLEMAEQQMDELPQEESSCIANVAEESSSILATANRSVDMKIDMETASVPTRQRQTMNTLRTEECVDSEGRLYTRKVVQIERFWDRGPVAVSQLQLQQHQQATKSGPMIEKFFSNVEGVKVRSKSPPKLINSSSASPRTYRCKRCLEQFSKLDDFRVHVCPDGNHKCELCDRTFASGKALQLHSRIHDGENEQRESHKNFICPTCGTQFSSRKSLRLHSRMHAPVRARHVDAPEGTANGNFTCLECGKTLSESYRKAHLSLHMGDSVTCSVCNRKFDSSDSLAMHAAVHIELGQSQQQQQQQQQQQQQIPPVSQQQQQQQQQITSTKQGQEESSQAAPKTGENAGENVQDPQKPYQCQHCGRRFTRPHEKVKHERIHTGEKPHACEVCGKTFRVSYCLTLHMRTHTGVRPYACQHCGKRFKASSVYNHHLLTHGEERAYKCPYCPKTFKTRVQLAGHKNSHTKPFRCTECSRPFASLYAARAHIQTHKKDNNFKFSCYICGASYGRAFALKDHLKVHAVQDTREAPEPAREEEVAEAEDYLISEEVDDLEELEEIDDEEGQLVTAAVTASASASSVILHRQSE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00653036;
90% Identity
-
80% Identity
-