Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.6 5.3e+02 1.6 0.0 88 106 61 79 30 108 0.57

2 3 4.5e-29 1.5e-26 93.5 2.8 2 108 173 277 172 279 0.93

3 3 1.7 5.6e+02 1.5 0.1 76 109 277 310 274 311 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.6	5.3e+02	1.6	0.0	88	106	61	79	30	108	0.57
2	3	4.5e-29	1.5e-26	93.5	2.8	2	108	173	277	172	279	0.93
3	3	1.7	5.6e+02	1.5	0.1	76	109	277	310	274	311	0.85

Coding Sequence: ATGAGCAGTACGCCGAATATTAATCACGAAAGCTCAATTAACGCTGACAGTGTATACACCAGCTATAAGTGGATACTAAATGACTGGGTTGATCTTTACGATTATAAGTACGGTGGGAGCGTTGAGTCTCCCGAAATTCAGTTTATGCACGATAAAGAATGCAAATGCGTATTAATATTTAGGGCTCGGTCAAAGCTTGAGATCCCTCCAGTGAAGGCAAAAGTGGAGGTTAAATTTCTCACCAAATTTGCCTATCATGGTCTGCGAGCCAGGGTGAGTTTGGTCGACAAAAACATGAAGAAACTACTACAAACACCAAAGAAATGTACGCATTGCGTCCCGCCGTTCGTTGTGCTAACTTTCAACCAATCTTTGGGACCAGCGGCAAATCCCTATTTACAAGACGGTGCTCTAATACTGTTCTTCGAAATGAGAGTAATTAAGGCTATCAACATGTCTCCAGTCAGCACAAGCGTTTCAAATTCCAACTCCAACAACGAAATTCGTACAAAATTTGCATCGATGTTTGAGAAGAACAAATTTTGCGATGTCACCTTCATCGTTGAGGACCAAACGCTGTCTGCTCACAAACTTGTACTTGCCGCGAAAAGCGCTATTTTCGAAGCCAAGTTCGAAACTGATCTGcaggaaaagaaagaagatcCTGTTAAGATTGATGACGTTAGTGCAAAGATTTTCAACATCTTTCTGAAATATATGTACACGGATACAGTGAATGGTATGGAGGATGTTGTGACTAAACTTATCGTCGTAGCGGACAAATATCAAGTAATGGACCTGGTAAACCTTTGTGAAACTTATATGACGGTCAACCTGCAACTAAGAAACGTCATCCAGTATCTTGTCATCGCCCATCGAATGCATCTATCACCATTAGAAGAGAAAGCAATCGAGCTTATAAAACGCAATAAACAAGTACTTGTTGATTCGGCCGAGTATAAATTGTCCGATTATCCCGCTTTGATCGGCAAAATTAATGATCGATAA
Protein Sequence: MSSTPNINHESSINADSVYTSYKWILNDWVDLYDYKYGGSVESPEIQFMHDKECKCVLIFRARSKLEIPPVKAKVEVKFLTKFAYHGLRARVSLVDKNMKKLLQTPKKCTHCVPPFVVLTFNQSLGPAANPYLQDGALILFFEMRVIKAINMSPVSTSVSNSNSNNEIRTKFASMFEKNKFCDVTFIVEDQTLSAHKLVLAAKSAIFEAKFETDLQEKKEDPVKIDDVSAKIFNIFLKYMYTDTVNGMEDVVTKLIVVADKYQVMDLVNLCETYMTVNLQLRNVIQYLVIAHRMHLSPLEEKAIELIKRNKQVLVDSAEYKLSDYPALIGKINDR

Sequence clustering based on sequence similarity using MMseqs2