Basic Information

Gene Symbol
-
Assembly
GCA_018246435.1
Location
DWLU01000687.1:5630-6159[-]

Transcription Factor Domain

TF Family
HMGA
Domain
HMGA domain
PFAM
AnimalTFDB
TF Group
Unclassified Structure
Description
This entry represents the HMGA family, whose members contain DNA-binding domains, also known as AT hooks due to their ability to interact with the narrow minor groove of AT-rich DNA sequences. They play an important role in chromatin organisation [1]. The high mobility group (HMG) proteins are the most abundant and ubiquitous nonhistone chromosomal proteins. They bind to DNA and to nucleosomes and are involved in the regulation of DNA-dependent processes such as transcription, replication, recombination, and DNA repair. They can be grouped into three families: HMGB (HMG 1/2), HMGN (HMG 14/17) and HMGA (HMG I/Y). The characteristic domains are: AT-hook for the HMGA family, the HMG Box for the HMGB family, and the nucleosome-binding domain (NBD) for the members of the HMGN family [2].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0065 5.3e+02 2.5 3.2 11 16 13 18 11 19 0.82
2 4 0.13 1.1e+04 -1.7 3.7 12 15 33 36 32 49 0.62
3 4 2.3e-10 1.9e-05 26.3 1.4 3 20 52 69 51 71 0.92
4 4 0.64 5.3e+04 -3.9 6.9 10 15 84 89 83 90 0.83

Sequence Information

Coding Sequence
atgtCTGATGATGGGTCAACGGCCGTTGAAAAGAAAGGGCGCGGCAGACCAAAAGCTAATGGAACTCAATCTgatgCCAAAGGAGATACTAAAAAGAGAGGGAGACCTGCAGCACCTGTGAAAACGAAAGAATCAAAaaattcatctgatgatgaacaGGTGCCAGCAGTAAAGAGAGGAAGAGGTAGACCTAAAGGATCCAAAAAAAGTGCAGCAGCATCTAAGGGCAAGGCTGGTGCAGGAGAAGGAAGAGGGCGAGGAAGGCCACGTAAAGAAGCAGCTCCGCCCAAAAAGGATGCTGCATCAACTGAGGAGGAACAAGATGAGGATGAAGAAGAGGAAGTATCTGACCAGTAA
Protein Sequence
MSDDGSTAVEKKGRGRPKANGTQSDAKGDTKKRGRPAAPVKTKESKNSSDDEQVPAVKRGRGRPKGSKKSAAASKGKAGAGEGRGRGRPRKEAAPPKKDAASTEEEQDEDEEEEVSDQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01115716;
90% Identity
iTF_01115716;
80% Identity
iTF_01494323;