Basic Information

Gene Symbol
ZEB2
Assembly
GCA_033220335.2
Location
CM067296.1:2675447-2681331[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 4.9e-05 0.0047 17.9 3.4 1 23 67 90 67 90 0.95
2 11 0.0031 0.29 12.3 0.9 1 23 96 118 96 119 0.96
3 11 0.0024 0.23 12.6 4.3 1 23 122 144 122 144 0.98
4 11 0.003 0.29 12.3 2.1 2 23 148 170 147 170 0.94
5 11 0.00026 0.025 15.6 3.0 1 23 173 196 173 196 0.97
6 11 0.011 1.1 10.5 3.9 1 23 199 221 199 222 0.95
7 11 0.032 3.1 9.1 0.1 3 20 231 248 230 250 0.93
8 11 7.1e-05 0.0068 17.4 0.1 2 23 263 285 262 285 0.94
9 11 6.6e-07 6.3e-05 23.8 1.0 1 23 291 314 291 314 0.98
10 11 0.0001 0.0096 16.9 0.7 3 23 325 345 324 345 0.97
11 11 0.00027 0.026 15.6 0.0 1 23 351 374 351 374 0.97

Sequence Information

Coding Sequence
ATGGCtaacttaaaagtaaaagaGGAGATAAAAGAAATCTTTAGTGAGCAGTGTCGGACTTGTCTCAGTATTGGAAGAAAAATGGTGCCATCCGGAGAATTCGCCGATATATTCCGTAGTATTACTTCGGTTACTTTATCTGAAATGGAAGTTCTTAATAATGTCaagaatgaaatattaaataaacatttggaAAAATTCAAATGCAAAGAATGTGGGATtggttttaaaaacaaaaagttattgGAGGTGCACACTTTTAAATGTCATGGTGAGGTTGAATCATATGTTTGTGCTGTATGTCACAATAATTTACcaaataaaattcaattgaCTGCTCATATAAACAATCATCATTATGTACACAAATGTAGAATTTGCGATCAAGTatgtgttaataaaaatcaaagaTGGCGTCATTTGAAAGTTCATAAAGTGTTGCAATGTTTAAAATGCGGTTTATTCTTTGGaagTCGAAAGGATttctttaaacattataaagaaAGGCATGAGAAATTTATCTGTGACTATTGTGGTATCAGTTTCAAAATGAAGTACTGCATTAAGGATCATATAAaGAAGCAGCACATGCCGTTCGAATGCAAACCATGCTCGAAACATTTCACCCGTTCCAATGGGCTATGGCTTCATAACAAAATTCATCATGGTCGACCATCCTCGCCTGCATACTGCGTGGAGTGTGATAGGAGGTATCCGGACAGCTACAGATACAGGTGGCACTTGGCAAACAGCGCAAAGCATAGGCCGCGTAAAAAATTGAGGATCCCATGTCCAGGATGTGATAAAGTGTTTTCGAAGAACATATACATGAAGGACCACTACAACCTAGTGCACTTGAAGAATTACAAGTACCGATGTGAGGAATGTAACAAGAACTTCATCAGAAACGCGGATCTGACTAAGCACAACCGTAGGGTCCACGAAGGCATCATGCCGCCGAAAAACAAGATCTGCTACATGTGCGGTCGAGGATTCAGTACCAACAAGATCCTGACCAATCATCTGCGGACCCACACCGGTGAGAGGCCTTTCGCCTGTGCTCAGTGCAAAGCGCGATTCGCACAGTCCGCCGCCCTGGCTTCTCACGTACGAACAATACACTGCCGCTAG
Protein Sequence
MANLKVKEEIKEIFSEQCRTCLSIGRKMVPSGEFADIFRSITSVTLSEMEVLNNVKNEILNKHLEKFKCKECGIGFKNKKLLEVHTFKCHGEVESYVCAVCHNNLPNKIQLTAHINNHHYVHKCRICDQVCVNKNQRWRHLKVHKVLQCLKCGLFFGSRKDFFKHYKERHEKFICDYCGISFKMKYCIKDHIKKQHMPFECKPCSKHFTRSNGLWLHNKIHHGRPSSPAYCVECDRRYPDSYRYRWHLANSAKHRPRKKLRIPCPGCDKVFSKNIYMKDHYNLVHLKNYKYRCEECNKNFIRNADLTKHNRRVHEGIMPPKNKICYMCGRGFSTNKILTNHLRTHTGERPFACAQCKARFAQSAALASHVRTIHCR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01115879;
90% Identity
-
80% Identity
-