Basic Information

Gene Symbol
L
Assembly
GCA_033220335.2
Location
CM067269.1:6483318-6487908[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.48 46 5.4 5.8 1 23 3 25 3 25 0.97
2 16 6.4e-06 0.00062 20.7 4.1 1 23 31 53 31 53 0.99
3 16 2e-05 0.0019 19.2 0.1 1 23 59 81 59 81 0.98
4 16 0.00047 0.045 14.9 0.0 2 23 97 119 96 119 0.96
5 16 4.6 4.4e+02 2.3 0.1 9 23 150 165 146 165 0.93
6 16 0.23 22 6.4 0.0 3 23 223 243 222 243 0.97
7 16 0.073 7 7.9 0.0 3 23 258 278 257 278 0.93
8 16 9e-05 0.0086 17.1 1.2 1 23 286 309 286 309 0.91
9 16 0.025 2.4 9.4 0.1 1 23 314 337 314 337 0.92
10 16 0.0002 0.019 16.0 0.2 1 23 388 412 388 413 0.96
11 16 0.00015 0.014 16.4 0.1 2 23 464 485 463 485 0.96
12 16 0.094 9 7.6 0.0 1 23 491 513 491 513 0.97
13 16 1.3 1.2e+02 4.1 0.5 2 23 521 542 520 543 0.93
14 16 0.58 55 5.1 0.2 3 23 619 639 618 639 0.95
15 16 0.0027 0.25 12.5 0.1 1 20 647 666 647 669 0.95
16 16 0.03 2.9 9.2 0.6 1 23 676 698 676 698 0.94

Sequence Information

Coding Sequence
ATGCCTTTCCGCTGCGAGTTTTGTTCAAGATTGTTCAAGCACAAGCGATCTCGCGACCGCCACGTGAAACTGCACACCGGCGACCGGAAATACCGTTGTGCACACTGTGAATCTGCTTTTTCTAGAAGTGACCATCTGAAGATCCACATGAAGACCCACGACAATCAAAAGCCATTCCAGTGTACTGTATGCAACCGTGGATACAATACGGCCGCGGCTCTGACGTCCCACATGCAGGGCCACAAGCGAGACCGCGATGGCCGCGACCAAGACCGCCGGAGGACTTTGCGCTGCTTGCAATGCGGCGATGCTTTTCGACGCCCTGAAATGCTTCAGgcCCATATAGCTACAGCACACGGCGTTGACTCAGTATCATTAACTCCTCCACGGCGCGTTGCTTCCCAGCCGCCACCCACTCTCCTCGCCTGCATATATTGCACAAGAGATACATTCACCAGTATGGAACAATTGCAACTGCACGTTCGCGCCGCGCATTCAGCACTATTAAACGGTGACACTACAATGCCGACAAATATAGAGCAACCAACGCCAACGGATCTCAGTCGGAGAACAAGTGTAGAACAAGATCCAACAACAGCGAAGCGTCCACGATCTAGCTCCGGTACTGCTACACCACAAACAACGTTATCCCCGAACACTCTTCTTTGCAACCAGTGTGATGCTGCGTTACCAGATTTTGAAGCGTTTAGAGCTCACCTCAAAGGGCATTTAGAACAGGGAGGAGAACTAAACCGCTCCAGTCCTGCCCCTTGCGTTcattgtggcgctagttttGCGGACATTGCAGCAACAGAGCGCCATTTAGCAGCACATTATCTGGCAGTATCCTGCGAGTACACTTGCCACAGCTGCGTGCGCAGTTTCCCTACACCGGATGACTTACAAAAACATCTATTTGATTTACATGCTCATCATTTGTATCGCTGTTCACTGTGCAAGGAAATCTTTGATTCTAAAGTAGCAATTCAGGTGCATTTCGCGGTAGCTCACAGCGGCGAAACGAAGGTGTGGATGTGTCGCCCGTGCGGCGCAAGTGGTGGAGCGATGCGCACGGAAGCGGAAGGAGCAGCTCACGTGCGCGCACGGCACGCGGCGGCCCGTTGCGCCTGCGGAGCGGTGTTGCCAGCGCCGCGTCGCGCTTATCGGTGCCCAGCCCCTACCTGCCCCGATAGCTTCGCAGTGCAGTATTTGTTAGAGAGACATATGCAGATGCATCATCCTGTGCCACAGGCATTAAACGGAGAAATCGTTCGCGGCAAGCGCGCGGATAACAACAATACAGAAGGAGACGGAACGTGCTCGCCGTGTGTTAGTGGTGAACCTGGATTAGTTGATGACCGGCGGAGGAAGAACGGCGCAGTAGCCCTACAGTGTGCGTACTGCGGCGAGCGCACGCGCAGCCGGGCGGAGCTAGAGGCGCACACCCGAGCGCACGCCGGCGCCGCCAGACACAAATGCTTGATCTGTGACGAAGTTCTTCCATCAGCTGGAGTCCTAGCTGAACACAAGCTCTCACATTGCAAGGTTATTGCTGGTGACACGTGTGCGCGATGTCGCGCCCGATTGCCTACCGAAGAAGCATTTCTTACTCATATGGCAAGGCAtcatcctgcgctgcctgcaccTTGCGTGGTTTGCCGGCAAACACTTGCGTCTGAAGCGGAAGCTCGGCTTCACGCTCGATTTCATCTTCGCCCAAATGAAGATGAACAACGATGTGCAATATGTCTTAGAACATTGACGGAGAGCGAAGCCGGAGAGGGGGTGAGGGCTTGTTCCACTTGTTATGCTCGTCATTCGACACCGAGACCACCTCCAACAGCCGATAACGATTGTCGACTTTGCAGGCGATCTCTCGGGTCGCCGACTCGACTACAAGCACACCTCATAGAACACACATTCGCAGGAATAGGCGCGTTCACGTGCTATTTATGTTCTGCTGTGTTTACAAGCGCTGCCGGTTTACAACGACACCTTCCCGAACATGCATCCGCACCGAGACCTTACGACTGCACGCGTTGCGGCATGAAGTTCTTTTTCCGCGCTGAACTCGATAACCATGCTTTTGTACATATAGAAGAAGCGGAGATAGCACAAAGAGCGTTTTATGAAGCTTACGCCAGAGGTGCCGCATCAGCATGGGCAGCCCTTGCTCCACCTCCAGATGCTACGCCTATGCCTTCTATAGCAGGTCCCGTTCCACCTGCTACAGATGTCTCTGTTAAAACAGAACCAGAGATAAAAGAGGAACGACATACTGAGGAATATATTGAAGTCTCATCTCCTCCGCCATCTGCACCGCCCCCTGCTCCCCCCGCTTCAACTTCTCCTGCTCCTGTAGTTAAGCAAGAGAAGACCGACGAAGACTGA
Protein Sequence
MPFRCEFCSRLFKHKRSRDRHVKLHTGDRKYRCAHCESAFSRSDHLKIHMKTHDNQKPFQCTVCNRGYNTAAALTSHMQGHKRDRDGRDQDRRRTLRCLQCGDAFRRPEMLQAHIATAHGVDSVSLTPPRRVASQPPPTLLACIYCTRDTFTSMEQLQLHVRAAHSALLNGDTTMPTNIEQPTPTDLSRRTSVEQDPTTAKRPRSSSGTATPQTTLSPNTLLCNQCDAALPDFEAFRAHLKGHLEQGGELNRSSPAPCVHCGASFADIAATERHLAAHYLAVSCEYTCHSCVRSFPTPDDLQKHLFDLHAHHLYRCSLCKEIFDSKVAIQVHFAVAHSGETKVWMCRPCGASGGAMRTEAEGAAHVRARHAAARCACGAVLPAPRRAYRCPAPTCPDSFAVQYLLERHMQMHHPVPQALNGEIVRGKRADNNNTEGDGTCSPCVSGEPGLVDDRRRKNGAVALQCAYCGERTRSRAELEAHTRAHAGAARHKCLICDEVLPSAGVLAEHKLSHCKVIAGDTCARCRARLPTEEAFLTHMARHHPALPAPCVVCRQTLASEAEARLHARFHLRPNEDEQRCAICLRTLTESEAGEGVRACSTCYARHSTPRPPPTADNDCRLCRRSLGSPTRLQAHLIEHTFAGIGAFTCYLCSAVFTSAAGLQRHLPEHASAPRPYDCTRCGMKFFFRAELDNHAFVHIEEAEIAQRAFYEAYARGAASAWAALAPPPDATPMPSIAGPVPPATDVSVKTEPEIKEERHTEEYIEVSSPPPSAPPPAPPASTSPAPVVKQEKTDED

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01141854;
90% Identity
iTF_01495203;
80% Identity
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