Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 6.7e-06 0.0021 18.8 0.7 2 78 32 102 31 109 0.80

2 3 0.00087 0.28 12.0 0.8 41 108 96 158 92 160 0.78

3 3 0.00041 0.13 13.0 0.0 6 44 240 277 235 290 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	6.7e-06	0.0021	18.8	0.7	2	78	32	102	31	109	0.80
2	3	0.00087	0.28	12.0	0.8	41	108	96	158	92	160	0.78
3	3	0.00041	0.13	13.0	0.0	6	44	240	277	235	290	0.81

Coding Sequence: atggaaGAGAAAGATTTGGATGAAAACAAaaaattgaaaccaaAGGTTTCGGAATTTGTTCGCAAATTTCAGAGCGACATGATTGAAATGACGAAAAAGATGTTCAACAATTCGTTGTATTCTGATgtcaaaatattcatcaatCACAAGGTCATCAAAGGGCACAAATTCGTTCTTCTGCGAAATCCATCATTCTCCAAAATGTTTGCCTCAAATCCAGACTTGAAAGAAATCTTATTCTCTGATCAGATATTCGATTCAGTTGAACGCGATATAAAATACCTCTTTTACGATGACTTCGATGAGAAGATGAAGGacgtattattattttcaccaGAAGCTTGTGAGACATTTTTGCGATACCTCTATGGAACTGAAATCAAAGAGGAAATCATCAATCTTGATTTGATGTTGGTCGCTTATCACTACTCTGATGAGGTGCTCAaagatttttgtcaaaatCACCTGATCAAAGATGTAAATGTGGGAAATGCAGTTCGAACACTTTTGGTTTCATTAGAAACTCATTCAGAAAAACTTAAACTTGAGGCATGCAAGTTGATAGCGAGAAATTTCAACGAGATGAAATTCAACCAGGATTTGAACGTTATCCTGGAAAACAAGGATGCACTTTCAGAGATTCTCAATGTTTTTGgcgaCTGCAAAACAATTCTTCTTGAGTCAAAAGTGGAGGACACGAATCTTGAAGACTCGTTGGACCAATTGCGCAGTTCAGATTTATTGATGACAGTTGGGGACTACCACTTCTTGGTCCACAAGAACATACTTTCTGAACGAAATGCAGTGTTCAAAGTGATCATCGATGCTGCTTCGTCGGATGGTTTTCCAACATCCGTCAACATCCCAGATGT
Protein Sequence: MEEKDLDENKKLKPKVSEFVRKFQSDMIEMTKKMFNNSLYSDVKIFINHKVIKGHKFVLLRNPSFSKMFASNPDLKEILFSDQIFDSVERDIKYLFYDDFDEKMKDVLLFSPEACETFLRYLYGTEIKEEIINLDLMLVAYHYSDEVLKDFCQNHLIKDVNVGNAVRTLLVSLETHSEKLKLEACKLIARNFNEMKFNQDLNVILENKDALSEILNVFGDCKTILLESKVEDTNLEDSLDQLRSSDLLMTVGDYHFLVHKNILSERNAVFKVIIDAASSDGFPTSVNIPD

Sequence clustering based on sequence similarity using MMseqs2