Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 7.5e-15 2.5e-12 47.5 0.1 4 109 15 115 12 116 0.88

2 2 6.5 2.1e+03 -0.6 0.0 77 103 115 141 113 145 0.71

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	7.5e-15	2.5e-12	47.5	0.1	4	109	15	115	12	116	0.88
2	2	6.5	2.1e+03	-0.6	0.0	77	103	115	141	113	145	0.71

Coding Sequence: ATGGCAGATAAAtcgtcaacaatttttccatttttcgcTGCTCTGTACAAATCGCCGTACCTTTCGGACATGTGGCTACGTATAGGCGATGCGGAAATTCCGGCTCACAAAGTCGTTCTCTCGTCGCGAAACAAAACGATGGCGAAAATGATCAAGAATATCGGTGTCAGTCAAAAACTTTGCGTCAATTACAAAGACTTGAACGAGGCTTTTCAAAAGTTCGTCAAGTTTTTGTACACCAATAAAATTAACCCGGAGGAcatagacaaaaaattgctgaTCATAGCTTCCGAGTTCAACGATGAGGCGCTCAAAAACCGCTGCGAAGATCATTTGACTCAACAAATGAACGAGAAAAACGTGGCGGATTTATTGAATGTCTCAATTGCTCATCGTTGCAAACTGTTGCATGAGAAGGCAAATAATTTCAACGCAATAACCTTGCCCAAAATTGTGCCTGGCGTTCAAAACGCTTGTTTTGGCATAGTTGGACTGCCAATTAGTAATAATGAAACCTCAATTTTCgctcataataaataa
Protein Sequence: MADKSSTIFPFFAALYKSPYLSDMWLRIGDAEIPAHKVVLSSRNKTMAKMIKNIGVSQKLCVNYKDLNEAFQKFVKFLYTNKINPEDIDKKLLIIASEFNDEALKNRCEDHLTQQMNEKNVADLLNVSIAHRCKLLHEKANNFNAITLPKIVPGVQNACFGIVGLPISNNETSIFAHNK

Sequence clustering based on sequence similarity using MMseqs2