Basic Information

Gene Symbol
-
Assembly
GCA_030523145.1
Location
JAQQRF010000201.1:164757-167208[+]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.00016 0.32 11.4 0.0 21 87 13 78 7 90 0.86
2 2 9.7e-05 0.19 12.1 0.1 17 92 349 423 333 444 0.83

Sequence Information

Coding Sequence
ATGGGAAAAACAAGAGGAGTTCACGAGACAACTCCTGAAATAAGAAACAGGATGGTTGGGATGTACGAAGCCGGTCTTGGGCTTCGTGAAATAGCAGTAGCCCTGAACTGTTCTCAAAGAACAGTGAAAAGGTGGCTGAATCGGTTCGACAAAGAAGGAACAGTTGAAACTCGAGAAAGGTGTGGTAGAAAAAGAGCCACTACTGCAGAGCAGGACGAAGCAATCGTCCAATTGGCCTCGCAAACCACGATCACCGCTGCAAAAGCAGTGCTTCCGGCTTTAGGACTCTCGTGTTCCGTTGATACTGTTCGTGAAAGATTGCATAAAGCTGGCATTCATAACTGGAGTCCATCTCGTAAACATATGCAAACCATCCCATTAAGaaatacTGACAGTGCAGGAGTACAACAAGCAGTCTGGCGTCTAACGGGGACACAACACGGTAAGAAGAAGGACTCAACAAGAAGCAAATCGAGtcgacaaatgaaaaagcgtGGATCAGAAAAAGTGAAACCCGTGCAAGACTATGACAACGGGGACAATTTTGTTCAGCCGGCACAAGAATGCTTGACTTCGAAACAAGTCGAAGATATTGTACCACCCCAATCCCAACCTGATAGTATTTTCACGCACCCAATGCAGCCGATGAACGCTGAACCATGTTGGCCTTTAGATttagttcaaaataataatgaaataccTCAGAGACCTGTACCAAATTTTCGAGACATCGTCAGCATGACTCACCAACCACTTCAAGCAGAGGCTGAAGAACAACAATTTCATGACAAAAATGCAAAGGACAAGTGTTGTCATCAGTATGAAGGAACTATCGAGAACCAAACTGAAAATCAATACATGATGAACCCACAAATGGAACAGGATGCACGGTTGAAGTATTACACACAAGAAAATGACGAACGGTCTTCAGTTCATGAAAATATTGCGGGTTCTTGTGGAGCATCCAGCAGTAGTCATGCAGAAAGTGATAACAACGAGAGTTCAAAGAACAATAAGAAGGGTGGCAAGATTAAAGGAACTTTGGAAACTACTATTGAGATTAGGAACAGGATGATTGGAATGGCTGAGGCTGGATTGTCTACTTTGTCTATAGCTTTAGCAATCAATCGATCGgAACGGACAGTAAAGAGATGGTTGGAAAGGTGGAACAAGGAAGGAAATGTTCAAACTAAAGAAAGAAAAGGTCGTAAACGAATCACAACGAAGGAACAGGACGATGCGATTATAGCTATGGCCACGCAGCAGCCTTTGACAGCTGCTAAACATGTTGCTCCAGCTTTAGGACTCAAATGTAGTGTCGACACTATCAGGGAAAGGTTGCACAAAGCTGGGATTCATAGTTGGAAATTGGGGAAAAAGCAGGGatatGGAAATGCAGTTCACACGATACACCTCTGGCAGCCAAGTGGAAATCGTCCAAACAAACTGAAACCTCAAAACGAGAAGAGAAGAAAGTCTCGCAAAAAGCAATGTACCTCTAGCAACATAGCTATTCCTAAAGAGAAAATAGATTTAGACTTTGCAAACAAACCCAATTGCGAACCACAAAAATTGATCTCAGAATCGAGCAATGAACTTCCAATGCCTCCTTCCTATTCATCAACGCCGTCAGTATCTCAGAGTCTAACCGATATATCAATGACAACTTCCACCCTGCTTGGACCGCAACCTCAACCTCTAAATCCAAGCGTTCAAAATACACAGATGGAAATTATGGGCCCGGTGGTTCCTCATCAACCAGAATCTTGCAGACTAATATGCCCCAGCGCCCAAGCCCCAATCCCGTGTCACGCCCCTACGAATTCCATTTACTCGTCAAACGCTGTTATTATAAATAGTCATCCAGTTCATATGGAGCATTCTGAACCGATGAACTATGAACCGTACATCTGGACTTTCTAA
Protein Sequence
MGKTRGVHETTPEIRNRMVGMYEAGLGLREIAVALNCSQRTVKRWLNRFDKEGTVETRERCGRKRATTAEQDEAIVQLASQTTITAAKAVLPALGLSCSVDTVRERLHKAGIHNWSPSRKHMQTIPLRNTDSAGVQQAVWRLTGTQHGKKKDSTRSKSSRQMKKRGSEKVKPVQDYDNGDNFVQPAQECLTSKQVEDIVPPQSQPDSIFTHPMQPMNAEPCWPLDLVQNNNEIPQRPVPNFRDIVSMTHQPLQAEAEEQQFHDKNAKDKCCHQYEGTIENQTENQYMMNPQMEQDARLKYYTQENDERSSVHENIAGSCGASSSSHAESDNNESSKNNKKGGKIKGTLETTIEIRNRMIGMAEAGLSTLSIALAINRSERTVKRWLERWNKEGNVQTKERKGRKRITTKEQDDAIIAMATQQPLTAAKHVAPALGLKCSVDTIRERLHKAGIHSWKLGKKQGYGNAVHTIHLWQPSGNRPNKLKPQNEKRRKSRKKQCTSSNIAIPKEKIDLDFANKPNCEPQKLISESSNELPMPPSYSSTPSVSQSLTDISMTTSTLLGPQPQPLNPSVQNTQMEIMGPVVPHQPESCRLICPSAQAPIPCHAPTNSIYSSNAVIINSHPVHMEHSEPMNYEPYIWTF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01493540;
90% Identity
iTF_01493540;
80% Identity
-