Temo001850.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Trisateles emortualis
Gene Symbol
MBD-R2
Assembly
GCA_947095525.1
Location
OX352730.1:17634593-17650680[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.5 5.3e+03 -2.4 0.1 28 44 423 444 404 447 0.65
2 2 9e-16 3.2e-12 46.3 0.0 5 62 753 809 749 835 0.90

Sequence Information

Coding Sequence
ATGGGCGTAAAAAAATGTTGCATTGACAAGTGTAAATCATGTTCTACAAGAAAGGAAGATAAGGGTGTGACATACCACAAGTATCCAAAAGATTTTACGTTATGCGATATTTGGATGTCCGTAACACATAAACAAATTGACACAGGTTTGCCTATGTATGTGTGCTCGAGGCATTTCTGTAAAAATGATTTTCAAATATACAAGGACTCTAAATACGTATTGAAATCAGATGCTGTACCATCTATTTTCCCTTGGACTAATAGAAAGACTTTGGCAAATATAAAAAAAATGGAGTCTGAAAATAATGAAACTGTAAATGATGATCATAAAACATCCAATGTTGAGAGTGTTGATGCTATCAAGAAGTATATCGAGGCTCAGGATAAAGAGCTTCAGGAGCAAAGAGATTCAACACCCTCATCAAGTATTGAAAAGAACAATGAAGATAGTATGGACAGTAGAGTGAGTCAGAGTGAGACTGTCTCTGTAGCCAGCAGTGTAATAGATATGATTATAAGTGAGTCTGAACTGGAGATTGCCAGGAAGAGGGATATGAAGAATAAGGTTATAAATACTGGAGACAAAGGTAACAGCAGCATGGCTCTGTCAGTCGGCTCTAAAGTTGAGGCAAAGGATTTTGGAGATGAGTGGCATTGTGCAGAAATCATTGAAGTGGACTATGATGAAATGGAAGTACTGGTGCATTATGAAACTGATGCAAAAAAACATGACGAATGGATAAGCGTAAGCAGTCCACGTTTGAGGCCAATTGGAAATAATGCAGTAAAACCTGGGCCCAGTTCTGCAGAAAGTTGGTCTTCTGATACAGTAGCTGCCACTAGCAGTGTTAAAGAGGAGATAAAAGAAGAGAAGGGAGAACAGAAAGTACATCCAATGTTTGTAGTTGGTGAGAGATGTCTCGCTAGGTGGCGCGATAATAGACGATTTGTGGCTACTATACGTAATGATTTGGGAAATGGGAGTTACGAGATTATCTTCGATGACGGTTGCCACTGGACTTGTAAAGTCTCGAGGCTTTACAAACTAAGGCCAGGGAAAGGGGGAGTGTCCAATGGCGCACCTAACTCCCCAGCCACTCCCCTCCCAGAATTTGGCGCAGGTCCTAGCAATGCTACCCCAAATATGTACCCAGCTTATCATACGCACTTATTTGACCCAACACGGGATTACCTAGGCTCGAAAAGCGAGCGTCGCGAAATGAAACGCAAATTAAATATAAAAGAGATATTTAATATAGGACAGAAGCGGCCCAAGACGCAGAAGATTCAGAAGGAAAAGGTAGAGAAAGCACCTACAGGGAAGAAACCAAGTATTATCAGAAAGAAGCCTGTAAAAATAAAACAGGAGCCTAAGGTGAAACTTGAGGTGAAAACTGAAATACCAGCTGTGGATGCTGTGGCTTCAATCATAGGCACTGTTAACCAAGAAATTAAACGTGAAGCTAAAGAAGAACCAATCACTCAAAAGAAAATTGAAGTAAAGCCTTTAAATGGAGAAGTAGACATGAAAGATGAACCAAAATTGGAGGTTGACAGTGATAAGAAGGAGGCTGAAGAAGTAGCGCCAGTTAGTGAAGATATTGATGATGGTGAAAAAATTGAGTTTGAGGATTTGAAACCATACCTAGATCCGGAGGTGTTAGAAGAAGAGACGAAGCTTGAACAATTTGAGAAACCAGACGAAGGGACACACGAAGAAGTTATAGATAGAATCAAAGAGGCTATCAACAAACTTGAAGGTGGTCTAAATCAAGCTGAACAAACAAGTTCACCTAAACCCGAAGTCAAACCTGAAGTGAAACTCGAAGTCAAACCTAATGTTAAACCTAAAACGTCTGAACTTGATGGCACTGAAGACAAGGTCGAACATATACCACCAATACCAGAAGTTAAACCTCCAGAAACAGGCCGAGCCAAGAAGAAAGAAACGAAAAAACTGTCGAAAATAAAGAAAGGAAAAAAACTAAGGTTGTTGCGAGAGAAGAAAGTGAAGAAACAAGTGGAAAAAGTGAAATCTGAATTAGAAGAAATGAAGAAGCAAGTAGAGGAGATGCGGAAGCAGATGTTAAAGAGTCAGGAATTGGCGAAAGAAGGAGATATGTCGGCGAAATTCATGTTGCCGGGTGAATGGTGCTGCAAGTGGGTGAATGGACAGCCTGTGGGTACCGTCAGTGAGATTGAGTGCGAGATAAAACATGATTCTACCGGAAAAATTCCGTTACCTAGAAGAAGTGTGCAGGTTGAAGATACCAGATTGCCAGAAGGTTGGACTAAGCATATGGTTAGAAGGAGTTTAGGCCATTCTGCCGGAAAATGGGATGTTGTACTAGTCAGCCCCGACAACCGCAGATTCCATACAAAGAATGAAATGCGTGTATACCTAGAAAACAATCCAGATAAAAGTCTGCACGCTTACGAAAACGCTCTGACAGACTTCGGTGTACATTTGAAGCTAGCCCGTCGTATGGGATGGATATCACACACCCCTGATGGAATGGTAGACGGACCAGTCAATCAGTTACCAGTTGGGACACTTAGTAGTACCTCACCACTTGTAAAACGAAGGAGTTTGGGCCTTAAGAAGAAAGGCATTAAAGTTAAAAATAAAATACCTAAAGTGACTATTAAGATGAAGCCTCCACAGAATATTCTCCCTCCCGAGGAAGAAGCAGTTCCTACACAAGTTACTGCTACATGCACATCCATGTCAGCTGTTGATTCTAACTTGGAACAACTGAACGCTCCTCCATTAGAAGATGGATATGTTTATGTCGGTTCTCTAAAAGTTCAAATAATAGAGACCCTACTCCGATGTCCCGCTGACGGTTGCTTTAAAAACTTCCGTAACACTACTCTGCTACAAATGCACATCAAACACTACCACAGAGAACTGAGAAAAATGATGGGCGCGACTCCCAAAGTCCTAGACCTTGCATATGCAAGAACAATGCCGGTTGAAGCTGAAACACCACGGGTGAAGGAAGACCAAAAAGTCATCAAAGTCAAAATACCTCGACTTCCGAAACCAAAACCAGAACGAGAGGAAGCAAAAATAGAAATTAAGGCCGATAGGATAGAACCAATACAAATCGATATAGCTGCAATAACACCAGTCAAATCAGGTGAAATTCCCATTCCAAGAAGTCAGGATTCACCAAAATTACGCCAAATTTTAATAAACAAACCAGTTAAAAGACCTAGGGTATTGTTACCTGTTCGGAGGGTGGATCCACAACCATCAGAACAGATGATCCCTGACTCCTTAAATGAAGACTTTGATTTTGAACCAAATGAATCGTTAGAACCCACTTTAGATATTCCTTCAATGGAGCATTTGGACTTCGAAACTGCGATATCGACGCATACTGTGACGAGACCTTTGCATGAGAAAAAACGCAAACCGAAAAAGAAGGCGTTGGTATTGCATCCTAAAGGAATAATGAGTGAAGAGGAGGATTGGTTTGCTGTAAATTCAGATTTTGACACGAGATCGAGTTTCCCTCGGTCCGGTACTCCTGATTCAAAGGTTGATCTTAAAGCCGCGGCTGTGTCCTCGGAATCTAATGAAGAGAGAAGAGAGAGGGCTTCTAATACGTATATATATAATGAGAATGGCCAACGCATAAAGATAGTGCATATGAAACGTGAAGAAATAATAAATTGTCACTGCGGGTTCCGTGAGGAAGATGGCTTAATGGTGCAGTGTGAACTGTGCCTCTGCTGGCAACATGCGATCTGTCTTAACATACAGCGGCAAGAGGACGTACCGGATAAGTACACATGCAGTATGTGCCTGAACCCAATCCGCGGTCGTCGGTCTGCGCGGTTCACGCACGACCAGGACCGCCTGTACGAGGGCCTGCTCCCCGGCGCCCCGCCCTGCGCCGCCCTCCGCCGCTCGCACGAGCTGGCCGGCAACCTGCTGCGCGTCGATGATGCGCTGCACGCGCTCAGGGTCAAATACTATGTCGCCACTAAAAAGGACCATCCTAAACTATACCTCTGGGCCAAAGACTGGGAGCAGGCAGAGATAGAGTACACGCAGGAGAAGCTCAACTCTGACTACTCTGATCTCAACATTATGATTAGTAGTATCGGCAAGGAGAACCTACCCATCAAGCCTGAAGATGTGAAGGACATGCCGCTTGACATTAGGACGTCACCATCTTTAGATAATGATAATGAAAGGTACTCACAACGGGACATTCCACTCGGCTCCCAGTCTTTGCTTAGCGGTCTTCTCTCCAGTCCTGGTGGAGCATCACTGGATTTGCCTATCAGCACTTCGGAGTTGGAGCGATTAGCCAAATCAGTACAAGAACAAGAATGTCAACGCGCGACAATAGTGGCGCCACAGCCGGAGGCCGCCATCGAGAACGGCGCGTGTCGTGAACGTTTGCTGAAGCACATCCAGCGGTGCCAGGCGCTCATCGACTCCAGGCTTGACTCCATCGAGGCGCAGGTCGCAGAATTGGAATCTCAGAACCCATCATTCCAAGACGACGAGACGGCGGAATTTATGCCGCGCACGAAGCAGACTATACAGATGTTGATGCGAGATCTTGACACAATGGAAGAGCTTGGTGTTATTACTTAA
Protein Sequence
MGVKKCCIDKCKSCSTRKEDKGVTYHKYPKDFTLCDIWMSVTHKQIDTGLPMYVCSRHFCKNDFQIYKDSKYVLKSDAVPSIFPWTNRKTLANIKKMESENNETVNDDHKTSNVESVDAIKKYIEAQDKELQEQRDSTPSSSIEKNNEDSMDSRVSQSETVSVASSVIDMIISESELEIARKRDMKNKVINTGDKGNSSMALSVGSKVEAKDFGDEWHCAEIIEVDYDEMEVLVHYETDAKKHDEWISVSSPRLRPIGNNAVKPGPSSAESWSSDTVAATSSVKEEIKEEKGEQKVHPMFVVGERCLARWRDNRRFVATIRNDLGNGSYEIIFDDGCHWTCKVSRLYKLRPGKGGVSNGAPNSPATPLPEFGAGPSNATPNMYPAYHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKRPKTQKIQKEKVEKAPTGKKPSIIRKKPVKIKQEPKVKLEVKTEIPAVDAVASIIGTVNQEIKREAKEEPITQKKIEVKPLNGEVDMKDEPKLEVDSDKKEAEEVAPVSEDIDDGEKIEFEDLKPYLDPEVLEEETKLEQFEKPDEGTHEEVIDRIKEAINKLEGGLNQAEQTSSPKPEVKPEVKLEVKPNVKPKTSELDGTEDKVEHIPPIPEVKPPETGRAKKKETKKLSKIKKGKKLRLLREKKVKKQVEKVKSELEEMKKQVEEMRKQMLKSQELAKEGDMSAKFMLPGEWCCKWVNGQPVGTVSEIECEIKHDSTGKIPLPRRSVQVEDTRLPEGWTKHMVRRSLGHSAGKWDVVLVSPDNRRFHTKNEMRVYLENNPDKSLHAYENALTDFGVHLKLARRMGWISHTPDGMVDGPVNQLPVGTLSSTSPLVKRRSLGLKKKGIKVKNKIPKVTIKMKPPQNILPPEEEAVPTQVTATCTSMSAVDSNLEQLNAPPLEDGYVYVGSLKVQIIETLLRCPADGCFKNFRNTTLLQMHIKHYHRELRKMMGATPKVLDLAYARTMPVEAETPRVKEDQKVIKVKIPRLPKPKPEREEAKIEIKADRIEPIQIDIAAITPVKSGEIPIPRSQDSPKLRQILINKPVKRPRVLLPVRRVDPQPSEQMIPDSLNEDFDFEPNESLEPTLDIPSMEHLDFETAISTHTVTRPLHEKKRKPKKKALVLHPKGIMSEEEDWFAVNSDFDTRSSFPRSGTPDSKVDLKAAAVSSESNEERRERASNTYIYNENGQRIKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHAICLNIQRQEDVPDKYTCSMCLNPIRGRRSARFTHDQDRLYEGLLPGAPPCAALRRSHELAGNLLRVDDALHALRVKYYVATKKDHPKLYLWAKDWEQAEIEYTQEKLNSDYSDLNIMISSIGKENLPIKPEDVKDMPLDIRTSPSLDNDNERYSQRDIPLGSQSLLSGLLSSPGGASLDLPISTSELERLAKSVQEQECQRATIVAPQPEAAIENGACRERLLKHIQRCQALIDSRLDSIEAQVAELESQNPSFQDDETAEFMPRTKQTIQMLMRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01492033;
90% Identity
iTF_01492033;
80% Identity
iTF_01492033;