Basic Information

Insect: Trichoplusia ni
Gene Symbol: Runx1
Assembly: GCA_003590095.1
Location: NC:2102770-2128970[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.8e-73 1.4e-69 231.4 0.0 4 129 45 170 42 170 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.8e-73	1.4e-69	231.4	0.0	4	129	45	170	42	170	0.98

Sequence Information

Coding Sequence: ATGCATTTATCAAGTGAAGTGAGTTCTACTACGAATGGACTGGGCCATGAGGCGCCATCTTCGAGTTACGGGAACAATTTGCCGAGTCAGCCTTTGACGGCGGAGTTGTTGGCTGAGAGGACCCTGGAAGGTCTTTTGGCTGATCATCCTGGAGAGCTCGTGAAGACCGGCAGTCCTCATGTGGTGTGTACAGTACTACCACCTCACTGGAGATCGAACAAGACGTTACCAGTGGCTTTCAAAGTGGTGGCTCTAGGAGAGGTCGGGGACGGCACGCTGGTCACCGTGAGGGCTGGCAACGATGAGAACTGCTCCGCGGAGCTCCGGAACTGCACCGCGGTGATGAAGAACCAGGTCGCCAAGTTCAATGACTTGAGATTTGTTGGGAGAAGTGGGAGAgGTAAATCCTTCACATTAACGATCATGCTGGCCACCTCCCCCCCTCAAGTGGCGACATACCAGAAGGCTATAAAGGTGACTGTGGACGGGCCCCGGGAGCCGCGCTCCAAGACCCGGCATCACGGCTTCCATCCCTTCCACTTCGGACCAAGGTTTCCGCCAGACCCGCTCATGGGGTCTTTACCTTTTAAGTTATCAGGCATAGCTCACCAACTAGCCGGTTTGCCTGGTGGCGAGTGGGGCGCGCTTGCGCGGCACTACCCCCCGCCGCTGCTGCCCACTCCTGCGCACTTCACGCCACACGTACTACCACCGGCGCACACGCAACACCACATACCTCCAGCACCGCATGAAACTGATGTGACGTCAGATAACCCTATCACAATGCACGCGCACAGCACGACGAGTCCAGCAAACTCACGTCCGAGCTCACCACAAGACGATGACATCTCTGTCACAGCATCCAGTAGCCCGCCACCGGACGACCGCCCCGGAGCTTTCACGTCCGTCACCAGGACAAGAAAACCCCTCCAGCCGCTACCAGCACCTTCATCCCTCTTCCACAGCGCGCTAGCAGCTCAACTATTCCTCAATTCCCCTTTACTACCAACGCCTCCAGCTTGGTTGTACTCGCAACTGTACGGTGGCTACGATTGGTGGTTAAGACCGCCTCCTCCTCAAGAGGATTCGAACCATTCGAGTCCAGAGAGGGAGGAGGAAAGCTCAATTGCTTCAGGAACAGTAAAGAAACGTCCAGCGTCTCCGGAATGGGCGGAGCAAGGGATGCGGACCCGGAGTAAATCGCTCATCACGTCAGAAAGACGGCCGGTTGACGTGTGGCGCCCCTACTAG
Protein Sequence: MHLSSEVSSTTNGLGHEAPSSSYGNNLPSQPLTAELLAERTLEGLLADHPGELVKTGSPHVVCTVLPPHWRSNKTLPVAFKVVALGEVGDGTLVTVRAGNDENCSAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIMLATSPPQVATYQKAIKVTVDGPREPRSKTRHHGFHPFHFGPRFPPDPLMGSLPFKLSGIAHQLAGLPGGEWGALARHYPPPLLPTPAHFTPHVLPPAHTQHHIPPAPHETDVTSDNPITMHAHSTTSPANSRPSSPQDDDISVTASSSPPPDDRPGAFTSVTRTRKPLQPLPAPSSLFHSALAAQLFLNSPLLPTPPAWLYSQLYGGYDWWLRPPPPQEDSNHSSPEREEESSIASGTVKKRPASPEWAEQGMRTRSKSLITSERRPVDVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00326858; iTF_00185911; iTF_00185082; iTF_00801575; iTF_00953295; iTF_01221266; iTF_01150999; iTF_00076225; iTF_01125218; iTF_00074250; iTF_01415595; iTF_01124377; iTF_00075232; iTF_01063521; iTF_00928430; iTF_00685203; iTF_01064405; iTF_01061654; iTF_01416545; iTF_00347298; iTF_00851491; iTF_01230283; iTF_00299921; iTF_01526789; iTF_00120262; iTF_00147073; iTF_00273385; iTF_00726058; iTF_00808876; iTF_01084908; iTF_00037549; iTF_00122126; iTF_00373678; iTF_01533710; iTF_00906831; iTF_00907650; iTF_00364689; iTF_00150258; iTF_00973493; iTF_00425142; iTF_00448790; iTF_00757910; iTF_00237239; iTF_00363800; iTF_00667129; iTF_00830937; iTF_01030905; iTF_01531737; iTF_00445882; iTF_00905884; iTF_00850365; iTF_00824480; iTF_01506115; iTF_00280904; iTF_01079666; iTF_01506940; iTF_01507839; iTF_01078848; iTF_01115489; iTF_01495557; iTF_01142900; iTF_01494838; iTF_01153629; iTF_01147201; iTF_01140714; iTF_01149350; iTF_01147882; iTF_01144333; iTF_00780043; iTF_00620996; iTF_00774284; iTF_00709955; iTF_01161091; iTF_00699873; iTF_00701733; iTF_00700776; iTF_00702665; iTF_00704724; iTF_01170343; iTF_00698953; iTF_00361387; iTF_00662860; iTF_00035413; iTF_01335701; iTF_01528053; iTF_01528972; iTF_00818136; iTF_00837240; iTF_00638426; iTF_01532799; iTF_00421124; iTF_00405702; iTF_00409062; iTF_00410052; iTF_01503623; iTF_01245708; iTF_00411182; iTF_00673265; iTF_00358294; iTF_01561793; iTF_00658134; iTF_00659237; iTF_00635175; iTF_00634089; iTF_00044236; iTF_00142869; iTF_00825354; iTF_01172103; iTF_00790017; iTF_00055174; iTF_00686114; iTF_00407341; iTF_01171238; iTF_01208980; iTF_01207886; iTF_00696278; iTF_00697100; iTF_00698045; iTF_00661052; iTF_00737247; iTF_00212200; iTF_00896547; iTF_00247816; iTF_00984799; iTF_01135527; iTF_00462145; iTF_01463030; iTF_00021113; iTF_01193387; iTF_00695250; iTF_00457786; iTF_00457018; iTF_01463935; iTF_00446888; iTF_00711585; iTF_00787394; iTF_00290439; iTF_01429707; iTF_00819834; iTF_01010141; iTF_01092836; iTF_01094669; iTF_00071185; iTF_01093810; iTF_01285317; iTF_00784169; iTF_00784972; iTF_00783198; iTF_01341992; iTF_01337548; iTF_01259853; iTF_00121168; iTF_00124007; iTF_01339730; iTF_01439666; iTF_01338259; iTF_01362868; iTF_01440761; iTF_01489914; iTF_01377243; iTF_00647773; iTF_00017951; iTF_00908584; iTF_00869396; iTF_00708949; iTF_01166362; iTF_00621795; iTF_01073381; iTF_01525702; iTF_00275018; iTF_01142186; iTF_00636044; iTF_00354861; iTF_00951566; iTF_01179278; iTF_01118031; iTF_00111373; iTF_00249488; iTF_00204147; iTF_00887988; iTF_01028988; iTF_01027071; iTF_01028032; iTF_00771647; iTF_01401055; iTF_00038464; iTF_01041512; iTF_01203019; iTF_01204641; iTF_00323244; iTF_00077261; iTF_01385485; iTF_01247854; iTF_00164097; iTF_00934513; iTF_00933362; iTF_00403541; iTF_00827759; iTF_00022577; iTF_00967825; iTF_00878643; iTF_01203816; iTF_01202246; iTF_00770875; iTF_00959187; iTF_01034309; iTF_00461329; iTF_01033494; iTF_00842424; iTF_01138739; iTF_00119382; iTF_01219558; iTF_00376876; iTF_00719980; iTF_00072493; iTF_00856375; iTF_00146172; iTF_00026616; iTF_00042404; iTF_00176880; iTF_00041555; iTF_00043252; iTF_01062527; iTF_01543672; iTF_00250235; iTF_00287835; iTF_01437740; iTF_01360379; iTF_00823701; iTF_01332318; iTF_01501859; iTF_00355901; iTF_00887197; iTF_00952478; iTF_00715583; iTF_01076159; iTF_00723744; iTF_01312018; iTF_01083074; iTF_00113115;
90% Identity: iTF_01083074;
80% Identity: iTF_00326858;