Odup014053.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Ochropacha duplaris
Gene Symbol
Runx1
Assembly
GCA_951361185.1
Location
OX592704.1:7556675-7576680[+]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.5e-73 2.4e-69 231.4 0.0 4 129 45 170 42 170 0.98

Sequence Information

Coding Sequence
ATGCATTTATCGAGTGAAGTGAGTTCGACAACGAGTGGGCTGGGGCACGAAGCGCCGTCTTCGAGTTACGGTAGTGGCCTACCGAGCCAGCCGCTTACAGCCGAGTTACTAGCGGAAAGAACCCTGGAAGGACTGCTGGCAGACCATCCTGGGGAACTAGTGAAGACTGGAAGTCCACATGTAgtgtGCACAGTACTCCCCCCACATTGGCGATCGAATAAAACGCTGCCGGTAGCGTTCAAAGTGGTGGCCCTCGGTGACGTTGGCGACGGAACCCTGGTCACCGTCAGAGCGGGGAACGATGAGAACTGTTCTGCTGAGCTAAGGAACTGCACAGCTGTTATGAAGAACCAGGTCGCCAAGTTCAATGACCTGAGGTTCGTCGGGAGAAGTGGTAGAGGTAAATCCTTCACTCTGACGATAATGCTGGCGACGTCACCACCGCAAGTGGCAACGTATCAGAAAGCCATCAAGGTGACGGTGGACGGGCCCCGGGAGCCAAGGTCCAAAACGCGGCATCATGGCTTCCACCCGTTCCATTTTGGGCCAAGATTTGCGCCGGACCCATTAATGGGTTCACTACCTTTTAAATTGTCAGGTATAGCTCATCAGTTAGCAGGTCTACCCGGCGGCGAATGGGGAGCGCTTGCCCGACACTACCCGCCTCCAATACTGCCGACACACGCACACTTCACACCTCACGTACTCCCACCGTCGCATACTCAACCACACCATATACCGCCACCATCTCAAGAAACTGATGTGACATCGGAAAACCCAACAACAATGCACGCACACAGCACAACCAGTCCTGCGAATTCACGGCCAAGTTCACCACAAGATGACGATATATCCGTCACCGCTTCAAGCAGCCCGCCACCAGATGACCGTCCAGGAGCCTTCACATCAGTCACGAGAACGCGAAAGCCGTTGCAGCCGCTGCCAGCACCATCAAGCCTTTTCCACAGCGCTTTAGCAGCGCAACTCTTTCTTAATTCACCACTTTTACCTACCCCACCCGCGTGGTTATACTCGCAGTTGTACGGTAACTACGACTGGTGGTTGAGACCTCCGCCTGCTCAAGAAGATTCCAACTCAAGTCCTGATAGGGAAGAGGAAGGATCGACGACATCGGGGATCGTAAAGAAACGGTCAGCGTCACCCGAGTGGTCGGAACAAGGAGTTAGGACACGCAGCAAATCTCTCATGACGTCAGAAAGAAGACCTGTTGATGTGTGGCGTCCTtactaa
Protein Sequence
MHLSSEVSSTTSGLGHEAPSSSYGSGLPSQPLTAELLAERTLEGLLADHPGELVKTGSPHVVCTVLPPHWRSNKTLPVAFKVVALGDVGDGTLVTVRAGNDENCSAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIMLATSPPQVATYQKAIKVTVDGPREPRSKTRHHGFHPFHFGPRFAPDPLMGSLPFKLSGIAHQLAGLPGGEWGALARHYPPPILPTHAHFTPHVLPPSHTQPHHIPPPSQETDVTSENPTTMHAHSTTSPANSRPSSPQDDDISVTASSSPPPDDRPGAFTSVTRTRKPLQPLPAPSSLFHSALAAQLFLNSPLLPTPPAWLYSQLYGNYDWWLRPPPAQEDSNSSPDREEEGSTTSGIVKKRSASPEWSEQGVRTRSKSLMTSERRPVDVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01487489;
90% Identity
iTF_00076225; iTF_00790017; iTF_01147201; iTF_01416545; iTF_00787394; iTF_00290439; iTF_01429707; iTF_00407341; iTF_00819834; iTF_01010141; iTF_01073381; iTF_00621795; iTF_00896547; iTF_01501859; iTF_00147073; iTF_01063521; iTF_00928430; iTF_00685203; iTF_01064405; iTF_01061654; iTF_01487489; iTF_01341992; iTF_00326858; iTF_00887988; iTF_00185911; iTF_00185082; iTF_00907650; iTF_01525702; iTF_00037549; iTF_00373678; iTF_00906831; iTF_01439666; iTF_00448790; iTF_00363800; iTF_00830937; iTF_01440761; iTF_00905884; iTF_00038464; iTF_00042404; iTF_00171529; iTF_00049672; iTF_00383391; iTF_00636044; iTF_01259853; iTF_01179278; iTF_01118031; iTF_01538513; iTF_01221266; iTF_00708949; iTF_00973493; iTF_00425142; iTF_00237239; iTF_01377243; iTF_01332318; iTF_00280904; iTF_00908584; iTF_00869396; iTF_00823701; iTF_01166362; iTF_01360379; iTF_01076159; iTF_00410052; iTF_00421124; iTF_01172103; iTF_00247816; iTF_00212200; iTF_00673265; iTF_01208980; iTF_01207886; iTF_00250235; iTF_00634089; iTF_00635175; iTF_00275018; iTF_00825354; iTF_01142186; iTF_01415595; iTF_00719980; iTF_00072493; iTF_00146172; iTF_01245708; iTF_01437740; iTF_00077261; iTF_01144333; iTF_01149350; iTF_01140714; iTF_01147882; iTF_01385485; iTF_00122126; iTF_00411182; iTF_00953295; iTF_00801575; iTF_01125218; iTF_01503623; iTF_00074250; iTF_01124377; iTF_00249488; iTF_00150258; iTF_01339730; iTF_01092836; iTF_00124007; iTF_01094669; iTF_00121168; iTF_00071185; iTF_01093810; iTF_01338259; iTF_00757910; iTF_00667129; iTF_00204147; iTF_01337548; iTF_00959187; iTF_00774284; iTF_00620996; iTF_00780043; iTF_01138739; iTF_01142900; iTF_01494838; iTF_01115489; iTF_01495557; iTF_01150999; iTF_01034309; iTF_00461329; iTF_01033494; iTF_00842424; iTF_00856375; iTF_01219558; iTF_00376876; iTF_00026616; iTF_00818136; iTF_00142869; iTF_00055174; iTF_00044236; iTF_00457786; iTF_00457018; iTF_01489914; iTF_00113115; iTF_01312018; iTF_00647773; iTF_00723744; iTF_00035413; iTF_00887197; iTF_01153629; iTF_00837240; iTF_00075232; iTF_01401055; iTF_00824480; iTF_01506115; iTF_01079666; iTF_01506940; iTF_01507839; iTF_01078848;
80% Identity
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