Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.35 1.2e+03 -0.4 0.0 27 48 10 31 7 36 0.80

2 9 0.2 6.9e+02 0.4 0.0 26 48 37 59 31 64 0.89

3 9 0.3 1e+03 -0.1 0.0 26 48 65 87 61 90 0.87

4 9 0.024 81 3.4 0.0 26 48 93 115 89 117 0.89

5 9 0.0036 12 6.0 0.8 22 49 127 154 123 158 0.87

6 9 0.019 63 3.7 0.0 23 46 157 180 154 186 0.77

7 9 0.00039 1.3 9.1 0.0 23 48 185 210 180 216 0.84

8 9 0.028 94 3.2 0.1 23 48 243 268 236 272 0.84

9 9 0.0017 5.7 7.1 0.2 22 45 271 294 266 300 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.35	1.2e+03	-0.4	0.0	27	48	10	31	7	36	0.80
2	9	0.2	6.9e+02	0.4	0.0	26	48	37	59	31	64	0.89
3	9	0.3	1e+03	-0.1	0.0	26	48	65	87	61	90	0.87
4	9	0.024	81	3.4	0.0	26	48	93	115	89	117	0.89
5	9	0.0036	12	6.0	0.8	22	49	127	154	123	158	0.87
6	9	0.019	63	3.7	0.0	23	46	157	180	154	186	0.77
7	9	0.00039	1.3	9.1	0.0	23	48	185	210	180	216	0.84
8	9	0.028	94	3.2	0.1	23	48	243	268	236	272	0.84
9	9	0.0017	5.7	7.1	0.2	22	45	271	294	266	300	0.83

Coding Sequence: ATGGTGCACAATTGCATCACACATGCATGCAATACATGTGAAAAGAAATGCTCAGACAAAAGTAATcttaaaaaacacatcgacTCGGCGCACAATGGTGTTTCACATGGATGTAAtatttgtggaaagaaattcacTCAGAAGACTCATCTCAAAAATCATATCGATTCAGTACACAATAGAGTCacatatgcatgtgatatatgcggaaatTCATTTACCCCAAAAAGAtctctcaaaatccacatggATAAGGTGCACAATAAAGTCActcatgcatgtgatatttgcgaaaagaaattcactcagaaaagtaatctcaaaatacacatcgattcagttcacagtaaaattttacatgcatgtgatatttgcgcaaacaaaccctttgaatgtgatatttgtcacaaatcatttgcttACCAAAGCTGCATCGAAAGGCACGTCAACGTAAGACATAATCGGAGTAAACCCtttaaatgtgatatttgtcacaagtcatttggacaaaaatataatctcAAACACATAATTGTAGTACATAATCAAagtaaaccctttgagtgtgacatttgtcacaaatcatttggacaaaaaagtaatctcactaaacacataaatacagtacataatcacagcaaacccttcgaatgtgatatacGTCAAAAATCTTTTGGAAGTAAAAGTCGCCAAAAACGGCACGTccatgcagtacataatcgtagcaaaccctttgaatgtgaaatttgtcacaaatcatttcgAAGGAAAGATGGCCTCAAAATACATATAATGGCGGTACATAATTGTAGAAAACCTtatgaatgtgagatttgtcacaaatcatttggattgaAACAGAATCTCAAAAGACATATAATGGAGGTACATAATTTTAGataa
Protein Sequence: MVHNCITHACNTCEKKCSDKSNLKKHIDSAHNGVSHGCNICGKKFTQKTHLKNHIDSVHNRVTYACDICGNSFTPKRSLKIHMDKVHNKVTHACDICEKKFTQKSNLKIHIDSVHSKILHACDICANKPFECDICHKSFAYQSCIERHVNVRHNRSKPFKCDICHKSFGQKYNLKHIIVVHNQSKPFECDICHKSFGQKSNLTKHINTVHNHSKPFECDIRQKSFGSKSRQKRHVHAVHNRSKPFECEICHKSFRRKDGLKIHIMAVHNCRKPYECEICHKSFGLKQNLKRHIMEVHNFR

Sequence clustering based on sequence similarity using MMseqs2