Basic Information

Insect: Tribolium madens
Gene Symbol: MBD-R2
Assembly: GCA_015345945.1
Location: JADDYM010000096.1:2991858-2996746[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.1e-16 3.7e-13 48.9 0.1 8 72 387 450 381 455 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.1e-16	3.7e-13	48.9	0.1	8	72	387	450	381	455	0.92

Sequence Information

Coding Sequence: ATGGGTCGTAAGTGTGGCGTAGAGGACTGTTTGTCCGATTCAAACAGACCCGAGGACATAGGAGTAACGTTTCACAAAGTCCCAAGCCATAGTGATACTCGCCAGAAGTGGATATCTTTATGTCGCATCCCTGAAGACAAGAAAAGCATGAAGGTGATTTATATTTGTTCTCGTCACTTTCTACGCATGGATTTTTGTAATTTTAAAGGAAAGAAATATATTTTGCGTCAGGGTGTACTCCCGAGTGTATTTCCTTGGGATAAGTCAAAACTGGAAGCTATCAAAACCACAAAGAGTGAACCTGAAAAGACACAAGATAAACCAGATGAGAAGGAAGCAGATAGTGAAAAAACTGAGACTGAGGAGGTTTCTATGAAAGAAGAACCAGAAGAACCAAATGAAGATAAAGTAGAAGATGGTCCACCAACAGATTCAGCAAAGAGTAAAGAGAAAAGTGGAGAAGCCAAAGAAAAAATAAGAATGAATGCGAATGGACCTATAAATTTTGCAATAAATTCTCGAATTGAGGCTTTAGATAATAACAATACATGGTACCCTGCCAGAATAGTGGAGGAGGATTATGAAGGAAACGAGGTGTTGATTCACTTTGAGAAGTTTTCTAGTAAATATGATGAATGGATTTGTATGGACAGTCCTAGATTAAGGCCCCTGCAGTCACACTCCGGTAAGAAAACTCTCCAACAATTCACTGTTGGGGAACGCTGTTTGGCGGCATGGACAGGCAATAGAAAATTTCCTGCTACTATAACTAAAGTTTTGCCCAATGATACATATGAAGTTTTATTTGATGATGGCTTTGTCAAGAACCTGAAAGCCCATCTGATTTGTAAAACAGAAGGTCGTCCAACGCAGTCTTCGCCATTGTTTGATCCCATCCAAAGTTCAAAGCAGGAACGTCGAGAAAAGAAGAGAAAAATTAACATTGCTGCTCTATTTGGAAAACGCCCGCGTTTGGATATCACAGACGAAAAACCCAAAACGCCAAGCCACTCTCACATTTCACAACCACAAAACACCACAGATCCATCTGAAGAAGTGTTTGACCCTTGGGTGCCACAGTGGGAAGATGGAAAACCAGTAGGTACAGAGGCACAAATTGAAACCACTGATGGAACTAGAAAGTCCATCATTGTTCCGGATCCACGATTGCCGGAGGGTTGGACTAAACATTTAGCCCAGAGGATGCATGGGGCTTCGGCGGGTAAATGGGACACCATAATAGTCAGCCCCGACAATCGCAGATTTCGGTCAAAATCCGAAATAAAGTCGTACTTGGAAGACACCAAACTGATGAAATACAACTGGTCAATGTTTGACTTTACAATTCATCGTCCACGAAACCGCAGAAAGGAGCCCGAATTAGCATCGAATTTCCACCCGGAAATCCCTGTTGAACAGCCACTTGTCGAGCATGATGAGAGTTCCGAGTTAGCCCCCGAAGAAGAAGAAAATAAAAGTCTTCTTAAAATACCAATCGTCGACGACGGTTACCAATGCCCTATCGACGGTTGTGGAAAAACATTTCGGAAAGAGAACTTAGCCCAAATGCACGTCAAACATTATCATCCCGAATACATGAAATTCCTTGATTCGACTCCGAACGTTGCTGATTTAGCTTACGCCAGAACCGTGGGCGAATCGCTCGATAAATCTCCCGGAAGCAAAACTCCGGCTGCAAAACCGTTACAAAAGTCGGCAATTCCACGATCTGCGACAAAAACACACTCACCACAACTCGATTCAGACAAACCTCACTCGCCACAATCGCACAAAATTAAAGATTCCGAGATCATTAAACTGTTGAACACGAAAACGGCTGATGGTAGGAAAGAGAGCGATCCTGTTAAAGCCTTGCCTGCCGGTTTGCCGTCTAGTATGTACCCTGATTTTAAGCTAAAAGACCTTTTGAGTAAGTCTGAAGGGATTCCGAGTCACAACGACCTCAGTTTGAGGGCTCTGAGTACGACTAGACCTCCCGCGGGAATAAAAACTTTGCTACCTGTCAGACCGGAAAATAAGACAAGTCAGCCGTCGCCGGAATCAGAAAACGTCACAAACAGATTAAAGTCAACTTTGAGGCGTAAGCGAGGATTGGTCGACTCGGTCGACAGTCCTAAAGGTAATGAACCACCAGAAAACACCTACATTCCACTGGAGACACCGCCACTTTCCGAACCTAATAACATTATTATTGAAGGTGGTAAGGTGATCAAAATTGTAAGAATGAAACAAGAAGAAATCATCAACTGCACCTGTGGATTCACCGAGGAAGATGGCCTTATGATCCAATGCGACTTGTGTTTGTGTTGGCAGCACGCCTCTTGCAACAACATCGAGCGAGAAAGTCAAGTACCAGAGAAGTACGTGTGTTACATTTGTCAAAATCCGATACGACAGAGACTGTCGAAAAAGTACTTCCACGACCAGGACTGGCTCAAACATGGTGTACTCGCAACAACGAGTTTTCACACAAAAGACGAGGAAATGCTTAGTAAGAGATTCGAAAAGTTGAAAAAGTCGCACGATATTTCTGGGGGGCTACTCGAAGTGAGGGAGTTTGTAAATACGCTAAAGGTTAAATTGAAAATAGCCGAGGCGAAAAACCACCCGAAATTGTATCTCTGGTCCAAACCATGGGAAAAATTACCGTTGCCTGAGAAGTGTGAAGATGAAAAGCCGAAAGAAATCAAAAGTGAGGATGAGATTAAGACGGAAAGTCCGATCAAAGCGGAGCCTAATTCCGATTCGATGTTAATGATGATTTTGAAGAATACCAAAGAGGAGAGTGCTGGTGAAGATAATTTGGATAAGTTGCCGCCCCCGATTATACCGCAACCAGAAGCTGCGATTGATTCCAGTGTTTGTCGAGTGAATTTATTGGAACACATTGCACATGCCCAGTCGCTGGTTGAAGAGAGATTGGATGATTTTGAAAAGCAAATTGACCAGCTTGAAGACACTTCTATTTATGAGAATGATGAAGATTACCCGAGGACGAGACAAACACTGCATATGCTACTTCGGGATTTGAATACGTTGCAAGAGTTGAGCCAACTAACGACATTATGA
Protein Sequence: MGRKCGVEDCLSDSNRPEDIGVTFHKVPSHSDTRQKWISLCRIPEDKKSMKVIYICSRHFLRMDFCNFKGKKYILRQGVLPSVFPWDKSKLEAIKTTKSEPEKTQDKPDEKEADSEKTETEEVSMKEEPEEPNEDKVEDGPPTDSAKSKEKSGEAKEKIRMNANGPINFAINSRIEALDNNNTWYPARIVEEDYEGNEVLIHFEKFSSKYDEWICMDSPRLRPLQSHSGKKTLQQFTVGERCLAAWTGNRKFPATITKVLPNDTYEVLFDDGFVKNLKAHLICKTEGRPTQSSPLFDPIQSSKQERREKKRKINIAALFGKRPRLDITDEKPKTPSHSHISQPQNTTDPSEEVFDPWVPQWEDGKPVGTEAQIETTDGTRKSIIVPDPRLPEGWTKHLAQRMHGASAGKWDTIIVSPDNRRFRSKSEIKSYLEDTKLMKYNWSMFDFTIHRPRNRRKEPELASNFHPEIPVEQPLVEHDESSELAPEEEENKSLLKIPIVDDGYQCPIDGCGKTFRKENLAQMHVKHYHPEYMKFLDSTPNVADLAYARTVGESLDKSPGSKTPAAKPLQKSAIPRSATKTHSPQLDSDKPHSPQSHKIKDSEIIKLLNTKTADGRKESDPVKALPAGLPSSMYPDFKLKDLLSKSEGIPSHNDLSLRALSTTRPPAGIKTLLPVRPENKTSQPSPESENVTNRLKSTLRRKRGLVDSVDSPKGNEPPENTYIPLETPPLSEPNNIIIEGGKVIKIVRMKQEEIINCTCGFTEEDGLMIQCDLCLCWQHASCNNIERESQVPEKYVCYICQNPIRQRLSKKYFHDQDWLKHGVLATTSFHTKDEEMLSKRFEKLKKSHDISGGLLEVREFVNTLKVKLKIAEAKNHPKLYLWSKPWEKLPLPEKCEDEKPKEIKSEDEIKTESPIKAEPNSDSMLMMILKNTKEESAGEDNLDKLPPPIIPQPEAAIDSSVCRVNLLEHIAHAQSLVEERLDDFEKQIDQLEDTSIYENDEDYPRTRQTLHMLLRDLNTLQELSQLTTL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01480951;
90% Identity: iTF_01480951;
80% Identity: iTF_01480951;