Tcas008893.1
Basic Information
- Insect
- Tribolium castaneum
- Gene Symbol
- zfh1
- Assembly
- GCA_000002335.3
- Location
- NC:9064589-9067440[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 8 0.63 37 4.6 0.0 3 23 240 261 238 261 0.94 2 8 0.0001 0.0062 16.5 0.9 1 23 307 329 307 329 0.98 3 8 9.5e-06 0.00056 19.7 0.3 1 23 335 358 335 358 0.96 4 8 5.9e-06 0.00035 20.4 0.2 1 23 364 386 364 386 0.98 5 8 1.1e-07 6.5e-06 25.8 1.1 1 23 392 414 392 414 0.98 6 8 4.4e-05 0.0026 17.6 0.7 1 23 420 442 420 442 0.98 7 8 1.5e-06 8.6e-05 22.3 3.3 1 23 448 470 448 470 0.98 8 8 5.5e-07 3.2e-05 23.6 1.3 2 23 477 499 476 499 0.96
Sequence Information
- Coding Sequence
- ATGGAAAATAAGACGCTGCAGATCGCTTCCGACTTAGGCATCGAATCAGAAGAAATCGAAATTGTGAGCATAAATACGATCTGCCGGTTGTGTGGCACTCACAACGAGCGTTTGATCGGAATATTCAGCGATGAGGGAGTTGCAAATGATCTCTCGAATAAAATCAATCTGTATCTGCCAGTGAAAGTAGCAGCTTCAGACGAACTGCCTCTGCAATGCTGCTGGAACTGTGCCTCAACGTTGCTGGCCTGGCACGAGTTGGTTGTAACGAGTGTTGAGACAGACCGCAGGTTTAGGAACTTGCAGCTTATTACAGAAAAACACATCGGCGAAGATGCGGCGTTTGATAGCCCCGTCAACCCCCCCAGTGATGACAATGCAGACAATGATGGGATGGAGCCCAAGACCATCGGCACAAGTCTGGATGATTTCAACCAAACTTCGCCAAACCAGGGATCGAAAAGTGCACAAAAATCGCCCAAGAAGAAGAAAAAAGACTCAATCACGTGTTTTCCTCTCCAAGAAACCGAAACACCTCTCGAAACCTACATTACCGACATCGAACAAGAACTAATGGACCCCGAATTGGTCGACGTTCCTGACTACAAAGTAGAAATTGAAACCGATCATCTCCTAACACAGGAAGACGACAAATGTAACGAAATAAAAACGCCAGAGATTAAGCCGGACGAGGAGGAAGAGCGGCCCTATTTCGGGTGCCAATACTGCCCTGCGATTTTCTTCGTTCAGAAAGCGATAGCCGACCACGTGAGAGAAGAACACGGCAAGGAATACAAGAATTGTAAAGTGCATGTGCCAAAGCAAGCGCCGCCGGTAAAGCGGGGAGAGGAGGACCCACATAAGATCGATGAAGAATTAATAAAGGAAGCAAAGGTGGTTGTAGACGGCCGTATTTACTACAACTGCAAGGAGTGCGGAAAAAATCTGCACTCGCCGTACACCTACGTCTGGCATATAAGAATACACACCGGTGAGCGCCCCTTCGTGTGCGACTTGTGTGGGAAACAATTCCGGGTGTCCCAAGGCTTGGTCAGACATTTGCGTGAGACTCACCAAGGTATTAAAAAGTTCCCCTGCGACCTGTGTGGGCGCATGTTCGCCACTCGACGTAACGTGGAAGAACACAGGAGGATTCACACAAACGAAAGACCGTACGTTTGCGACCTCTGTGGCAAGTCTTTCAAGCAGAAGGCGTCACTTTTCGTGCACAAGAGGTCGCACAAGAACCACTTCCCGTTCAAGTGTAGTTACTGCAATCAAGGGTTTCGAACCAAACCGCCTTTACTGGTGCATATCACGAGACATACAGGCGAAAAACCGTACAAGTGTGATATTTGCGGCAGGTGTTTCCGAATTAAGTACGAATTGAAGCGACATAAACTTATACATTCGGATGAGAAGCCGTGGGTGTGCAATGTGTGTGGATTCAGTTTTAGACAGAAGCGGTATTTGAGGAACCACATGAAGTCGAACCATACGCTGGTGGCTTAG
- Protein Sequence
- MENKTLQIASDLGIESEEIEIVSINTICRLCGTHNERLIGIFSDEGVANDLSNKINLYLPVKVAASDELPLQCCWNCASTLLAWHELVVTSVETDRRFRNLQLITEKHIGEDAAFDSPVNPPSDDNADNDGMEPKTIGTSLDDFNQTSPNQGSKSAQKSPKKKKKDSITCFPLQETETPLETYITDIEQELMDPELVDVPDYKVEIETDHLLTQEDDKCNEIKTPEIKPDEEEERPYFGCQYCPAIFFVQKAIADHVREEHGKEYKNCKVHVPKQAPPVKRGEEDPHKIDEELIKEAKVVVDGRIYYNCKECGKNLHSPYTYVWHIRIHTGERPFVCDLCGKQFRVSQGLVRHLRETHQGIKKFPCDLCGRMFATRRNVEEHRRIHTNERPYVCDLCGKSFKQKASLFVHKRSHKNHFPFKCSYCNQGFRTKPPLLVHITRHTGEKPYKCDICGRCFRIKYELKRHKLIHSDEKPWVCNVCGFSFRQKRYLRNHMKSNHTLVA
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01480522;
- 90% Identity
- iTF_01480522;
- 80% Identity
- iTF_01480522;