Basic Information

Gene Symbol
-
Assembly
GCA_000002335.3
Location
NC:12960986-12970729[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 6.8e-05 0.004 17.0 2.4 1 23 409 431 409 431 0.97
2 18 2.1e-05 0.0012 18.7 2.5 1 20 437 456 437 459 0.94
3 18 2.3e-05 0.0013 18.5 1.3 1 23 465 487 465 487 0.98
4 18 3.7e-05 0.0022 17.9 4.4 1 21 493 513 493 515 0.95
5 18 2.1e-05 0.0012 18.7 4.6 1 23 521 543 521 543 0.99
6 18 2e-05 0.0012 18.7 5.3 1 23 549 571 549 571 0.97
7 18 2.4e-06 0.00014 21.6 7.1 1 23 577 599 577 599 0.97
8 18 7.6e-08 4.5e-06 26.3 2.7 1 23 605 627 605 627 0.98
9 18 5.6e-05 0.0033 17.3 6.7 1 23 633 655 633 655 0.97
10 18 3.3e-05 0.0019 18.0 5.8 1 23 661 683 661 683 0.97
11 18 2.5e-07 1.5e-05 24.7 2.9 1 23 689 711 689 711 0.98
12 18 2.6e-05 0.0015 18.4 8.0 1 23 717 739 717 739 0.98
13 18 2.2e-05 0.0013 18.6 9.1 1 23 745 767 745 767 0.98
14 18 1.3e-05 0.00078 19.3 7.7 1 23 773 795 773 795 0.98
15 18 8.6e-06 0.0005 19.9 7.1 1 23 801 823 801 823 0.97
16 18 6.3e-05 0.0037 17.2 0.5 1 23 829 851 829 851 0.97
17 18 0.069 4 7.6 5.0 1 23 861 883 861 883 0.98
18 18 4e-07 2.4e-05 24.1 1.3 1 23 889 911 889 911 0.97

Sequence Information

Coding Sequence
ATGAATACCAATGATCCGAACGCCCTTGCGGGGGCTCACGGGGCTGAAGCCGCGGAGGCCACCACCCAACGTCCACCACCAACCACTTCAATCCCGACCGATCTTCGCGTGAATACGACAGCCCTCAACGCTGTGGCGCTTTCCAGCGTGGCGAAATACTGGGTGTTGACGAATCTCCTCCCGGGACCCATTCCCCAAGTGAGTGTTTATGGGTTGCCGGGATCGGGACGTAGTGATAATCAGGGGAAAATAACATCGCAGGAGGCTATGTTGGGGCAACATGCGGCTGGGTTGTTACCAGCTGATCCCTTACTTTTACAACAACATTCGCAAATTCCTGTCAGTATTTCGACATCGCAAGGGGTTACGAGTTTGTCGATACCGACAGGTAGTATGCATCTGGAGGCCAATCACCAGGGGCATCAGGGCATGGGAGGGCATCAGCAGAATGATCCCATGAATCAGAATCAGATGAATCGAGATCATAATTTCCAGATGTCTCATCAACAGCAACAAACCCACACCAACCAGCAAAACATGGTGCAAGTCCAAGTCCAAGATAATTTAGTTTCAGTAATTGAAGATAGCAAAGAACAAAAAGATATAATCGCTGCTCAACTAGCCCATGCTCAGATTCAATTAAACGATAATCAACACTTGAATCAGCAGGCATTGACCGTTCAACAATTACAACATCTTCAAGTGCAACAAGTCCTTGATAATGTTGTCCGGATGGAAAATTCGGTCGAAAACACGCAAAATCAAGCAAACACCGCCGATCAAACCCAACTATCCGACAACATCCAGATTGTAAAAGACGAGAAAAACTTACAAAATTGTAAGTTACTGTCTGGGACACAGTTTGGTTTGCAAGACCATAAAGGTAACTTGATGGATGTGCGGACTGCTGATGGTAGTATTGTCAAGATTTCGACGAATCTTCAAGAGCAAGACTTGGCAAAGACTTTGGGTGTTGAAATGGTGCAAAATATGTACAAAGTGAACGTGGACGACTTGAACCAATTGTTGGCGTATCATGAAGTTTTCGGTAAGCTTCAAGGTGAGATTGCAACAACTGGTCAAAACATCGTCCAAAATACAAACAACACGAACGTGAATCTCCAACAAAACACAAACAACATTGCAATAGTGACAAAAGACGAGCAGGAGGCTTCGACTAGTAGTTTACCGACCGACAACACCGCCACGGTGATTACAGGGAACCACGTCTGTGATTTATGCGGGAAAATGTTTCAGTTTCGTTACCAGTTAATCGTCCATAGACGTTACCACACCGAACGTAAACCGTTTACGTGTCAAGTTTGCGGTAAAGCGTTTACCAATTCGCAGGAACTCACCCGTCACGGGAAGTGCCATCTAGGCGGTAGTATGTTCACGTGTGCGACGTGTTTCCACGTGTTCGCAAACGCGGCCTCTCTGGAGCGTCACATGAAGCGACACTCCACCGATAAACCGTACAATTGCACAATTTGCGGGAAGTCATTCGCGCGGAAAGAACACTTAGATAATCACACGCGGTGTCATACGGGGGAAACCCCCTACAGATGTCAGTATTGTGCCAAAACCTTCACCCGCAAGGAACACATGGTGAATCACGTGCGGAAACATACAGGGGAAACACCGCATCGTTGCGAAATCTGCAAGAAGAGTTTCACGCGGAAGGAACACTTCATGAATCATGTGATGTGGCATACGGGGGAAACCCCCCACCACTGCAACATATGCGGGAAGAAGTACACACGGAAGGAACACTTGGCCAATCACATGCGCTCGCATACGAACGATACGCCGTTCAGATGCGAGATTTGTGGGAAATCCTTCACGCGGAAGGAACACTTCACGAATCACATCATGTGGCATACGGGGGAAACCCCCCACCGGTGTGACTTCTGTTCCAAGACGTTCACACGCAAGGAACATCTACTAAATCACGTGCGACAACACACGGGGGAATCACCGCATCGCTGTGGTTTCTGTTCCAAGTCGTTCACACGGAAGGAACATTTGATCAATCACGTGAGACAACATACCGGCGAAACGCCGTTCAGGTGCAATTACTGTCCCAAAGCTTTCACCCGCAAGGACCATTTGGTTAATCACGTGCGGCAGCACACGGGGGAATCACCCCATAAGTGTACGTTCTGTACCAAGTCATTCACGCGGAAGGAACATTTGAACAACCATGTGAGACAACATACGGGGGAATCCCCCCATAGGTGTCACTTTTGTTCCAAGTCCTTCACCCGCAAGGAGCATCTCACGAATCACGTGAGGATCCACACAGGGGAGTCCCCACATCGGTGCGAGTTCTGCCAAAAGACATTCACTCGGAAGGAACATCTAACCAATCATTTGAGACAACATACGGGGGAAACCCAGCATTGTTGCAACGTTTGTTCCAAACCCTTCACCCGCAAAGAACATCTGATCAACCATATGAGATCACACACCGGCGAACGCCCGTTTGCTTGTACCGAATGTGGAAAGTCGTTTCCACTCAAAGGCAACTTGCTCTTCCACCAAAGGTCGCACAACAAGGGCGCGTTAGCCGATCGGCCCTTCCGTTGCGACCTCTGTGAGAAGGATTTCATGTGCAAAGGGCATTTGGTGTCGCACCGTCGGTCACACAGCGGCGAAAGGCCACATTCGTGTCCCGATTGTGGTAAAACTTTCGTCGAAAAAGGGAATATGTTGCGACATTTGCGTAAACATACCGTCGAAAACGGGCAAAGTAATGATCAAGTGGCGACGAATCAAGCGCCTCAAACGTCGAATGCTAACTTGCAAATACCGCAAGTTAGTCAAACGCAAACGGCGCCTAGCAATAACATCGTGACGCAAATGCCGATGCATCCGCCGAGTAATCATCCGGTCGTTGTGCCTACCGCCAACGGAAATGTCTTGGCTAGTTATTAG
Protein Sequence
MNTNDPNALAGAHGAEAAEATTQRPPPTTSIPTDLRVNTTALNAVALSSVAKYWVLTNLLPGPIPQVSVYGLPGSGRSDNQGKITSQEAMLGQHAAGLLPADPLLLQQHSQIPVSISTSQGVTSLSIPTGSMHLEANHQGHQGMGGHQQNDPMNQNQMNRDHNFQMSHQQQQTHTNQQNMVQVQVQDNLVSVIEDSKEQKDIIAAQLAHAQIQLNDNQHLNQQALTVQQLQHLQVQQVLDNVVRMENSVENTQNQANTADQTQLSDNIQIVKDEKNLQNCKLLSGTQFGLQDHKGNLMDVRTADGSIVKISTNLQEQDLAKTLGVEMVQNMYKVNVDDLNQLLAYHEVFGKLQGEIATTGQNIVQNTNNTNVNLQQNTNNIAIVTKDEQEASTSSLPTDNTATVITGNHVCDLCGKMFQFRYQLIVHRRYHTERKPFTCQVCGKAFTNSQELTRHGKCHLGGSMFTCATCFHVFANAASLERHMKRHSTDKPYNCTICGKSFARKEHLDNHTRCHTGETPYRCQYCAKTFTRKEHMVNHVRKHTGETPHRCEICKKSFTRKEHFMNHVMWHTGETPHHCNICGKKYTRKEHLANHMRSHTNDTPFRCEICGKSFTRKEHFTNHIMWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCGFCSKSFTRKEHLINHVRQHTGETPFRCNYCPKAFTRKDHLVNHVRQHTGESPHKCTFCTKSFTRKEHLNNHVRQHTGESPHRCHFCSKSFTRKEHLTNHVRIHTGESPHRCEFCQKTFTRKEHLTNHLRQHTGETQHCCNVCSKPFTRKEHLINHMRSHTGERPFACTECGKSFPLKGNLLFHQRSHNKGALADRPFRCDLCEKDFMCKGHLVSHRRSHSGERPHSCPDCGKTFVEKGNMLRHLRKHTVENGQSNDQVATNQAPQTSNANLQIPQVSQTQTAPSNNIVTQMPMHPPSNHPVVVPTANGNVLASY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00167784;
90% Identity
iTF_00415298;
80% Identity
-