Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 11 0.011 35 4.1 0.2 22 48 11 37 7 41 0.82

2 11 4.9e-06 0.015 14.9 0.2 21 47 38 64 34 69 0.87

3 11 0.00015 0.46 10.2 0.1 21 45 66 90 63 97 0.91

4 11 0.21 6.5e+02 0.1 0.4 26 48 99 121 93 123 0.81

5 11 5.6e-05 0.18 11.5 0.1 21 47 123 149 117 154 0.86

6 11 0.021 66 3.2 0.2 22 52 152 182 147 183 0.83

7 11 0.015 47 3.7 0.1 21 44 179 202 177 206 0.89

8 11 0.0018 5.6 6.7 0.0 21 47 207 233 203 239 0.85

9 11 0.0051 16 5.2 0.1 21 46 263 288 255 295 0.84

10 11 0.1 3.2e+02 1.0 0.1 23 48 293 318 287 322 0.80

11 11 0.0033 10 5.8 0.5 21 46 319 344 311 350 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	11	0.011	35	4.1	0.2	22	48	11	37	7	41	0.82
2	11	4.9e-06	0.015	14.9	0.2	21	47	38	64	34	69	0.87
3	11	0.00015	0.46	10.2	0.1	21	45	66	90	63	97	0.91
4	11	0.21	6.5e+02	0.1	0.4	26	48	99	121	93	123	0.81
5	11	5.6e-05	0.18	11.5	0.1	21	47	123	149	117	154	0.86
6	11	0.021	66	3.2	0.2	22	52	152	182	147	183	0.83
7	11	0.015	47	3.7	0.1	21	44	179	202	177	206	0.89
8	11	0.0018	5.6	6.7	0.0	21	47	207	233	203	239	0.85
9	11	0.0051	16	5.2	0.1	21	46	263	288	255	295	0.84
10	11	0.1	3.2e+02	1.0	0.1	23	48	293	318	287	322	0.80
11	11	0.0033	10	5.8	0.5	21	46	319	344	311	350	0.85

Coding Sequence: ATGGAAGTGCATATGGGGACAAAAACAGGCGAGAAGACGTATAAATGTGGTGTGTGCGATTATAGTTGTAGACATTGTGGAGATTTGAAACGACATATGCGAATACATACAGGCGAGAAGCCGTATAAATGTAGTGTGTGCGATTATAGTTGTAGGCAGTCTGGAGATTTGAAAAGACATTTGCAAACACATACAGGCGAGAAGCCGTATAAATGTAATGAATGCGATTATGTTTGTACATCGTCTGGAAATTTGAAAAGACATTTGCAAACACATACAGGACAAAAAACGTTTAAATGTGGTGCGTGCGATTATAGTTGTAGAAGATTTCAACATTTGAAAAGACATGTGCTAACTCATCATACAGGCGAAAAGCCGTTTAAATGTAGTGTGTGCGATTATAGTTGTACGCAGTCTGGAGATTTGAAAAGACATTTGCAAACACATACAGGACAGAAGCCGTATAAATGTAGTGTGTGCGATTATAGTTCTACAATATCTGCACATTTGAAACGACATATACGAATGCATACTGGCGAAAAGCCGTATAAGTGTAGTGTATGTGATTATAGTTGTACGCAGTCTGGAGATGTGAAACAACACATACGAACACATACAGGCGAGAAGCCGTATAGATGTAATGAATGCGACTATGTTTCTATATCGTCTGGAAATTTGAAAAAACATTTGCAAACACATACAGGACTGAAGCCGTATAAATGTAGTGAGTGCGATTATAGTTGTATAGCATGTGCACATTTGAAACAACATATGCGAATACATACAGGCGAGAAGCCGTATAAATGTAGTGTGTGCGATTATAGTTGTACACTGTCTGGAAATTTGAAACACCATATGCGAACACATACAGGCAAGAAGCCGTACAAATGTAGTGAGTGCGAGTATAGTTGTACAACATCTGGCCATTTGAAACGACATATGCGGGTACATACAGGCGAGAAGCCGTATAAATGTAGTGTGTGCGATTATACTTGTGCGCAGTCTGGACGTTTGAAACAACATATACGAACACATACAGGCGAGAAACCATATTAA
Protein Sequence: MEVHMGTKTGEKTYKCGVCDYSCRHCGDLKRHMRIHTGEKPYKCSVCDYSCRQSGDLKRHLQTHTGEKPYKCNECDYVCTSSGNLKRHLQTHTGQKTFKCGACDYSCRRFQHLKRHVLTHHTGEKPFKCSVCDYSCTQSGDLKRHLQTHTGQKPYKCSVCDYSSTISAHLKRHIRMHTGEKPYKCSVCDYSCTQSGDVKQHIRTHTGEKPYRCNECDYVSISSGNLKKHLQTHTGLKPYKCSECDYSCIACAHLKQHMRIHTGEKPYKCSVCDYSCTLSGNLKHHMRTHTGKKPYKCSECEYSCTTSGHLKRHMRVHTGEKPYKCSVCDYTCAQSGRLKQHIRTHTGEKPY

Sequence clustering based on sequence similarity using MMseqs2