Basic Information

Gene Symbol
ZFX
Assembly
GCA_001594055.1
Location
NW:185292-220582[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 9.1 6e+02 0.6 2.3 1 23 434 458 434 458 0.91
2 12 0.42 27 4.8 2.4 2 21 515 534 514 538 0.88
3 12 0.00045 0.029 14.1 0.2 2 23 553 575 552 575 0.97
4 12 0.35 23 5.0 0.9 1 23 594 618 594 618 0.92
5 12 0.022 1.5 8.8 0.3 1 21 664 684 664 685 0.95
6 12 0.00053 0.035 13.9 0.3 1 23 746 767 746 767 0.98
7 12 1.9e-05 0.0012 18.4 1.0 1 21 773 793 773 794 0.95
8 12 7.5e-05 0.005 16.5 4.9 1 23 811 833 811 833 0.98
9 12 0.0034 0.22 11.3 0.1 1 23 838 863 838 863 0.96
10 12 4.4e-05 0.0029 17.3 0.9 1 23 870 892 870 892 0.98
11 12 0.13 8.8 6.3 3.3 1 23 904 928 904 928 0.95
12 12 0.00099 0.065 13.0 1.7 1 21 934 954 934 959 0.94

Sequence Information

Coding Sequence
ATGGAAGGCTATGAAGAAGACGATGACACTCATTTCTGCATCAAGTGTAATTTGACAATTCATGGGCTCGACAATTATGTGCAGCATCGTCGATCAGGCTGCCGACCATCGGATGCTAAAATCGAGATGGTTCACGAGCCACCTTCGACGCCGACAACGGTGTCCTATCCCGAATGTCTAAACGCAGACGCATTCTTCAGCTCGTTAGAATTACAGAGTAACACCCGACAACGAGCGACAACTTTACTGGATAACAGAAAATTCAAGAAAGAtgacaaaagaaagaaagaccAGAAAGGTCAGGTGGATGGTGATGAGCCCGGCACGAAGGATAAACTTCACAGCATGTTACCCGCGGTCAGCGATCTGGACGAACCGCCCGATCTGTGCATCCAGTCCCTCAAGCCGACAACCCTCGAACGAAAGAGGCACGAGAATCAGCAGAGTTGGTTAGATGACACCATTCTCGCTGACCTTTCTTTGGGGAATAGCGCGAACAAGAAGCTGGCGAGATACGACTTCGAGTACGATGACTCCGAAGACGATATCCTGGAGGGGGAATTGGGGGAAGATTCCTATTCGGATTCAGATGACGGCGAAAATCCACGGGAAGGTCCACCGCGAGATCACACTGGTGGAAAGTGGAAGCCCGGACTGGACGATTTGCCGCAGGACACGCCGCATATGCATGAGGAGGATGCAGCAGAGCCCGACAATGATCATCAGGAACATCCCCCGCCAACATATACTGGCGGTAAATGGCGACCCGCGGAGACATCACaaAAGGTCGAGGAATACGAAAGCAAGGACACATCCGGACAGCCGCCGCCAGGATACACGCGAGGGAAATGGGTACCGGGTGCACGAACGGATATCGAGTCGGGATATTGGTGCAATCCTTGCGGCAGGAAGCTCGCATCGCGATTGGTTTACAACAGGCATCTGCTCTCTGATTTGCACGCCAGGAGGAGCATTAGAGAACTTGACGGTGGAGCTCTCCATCTACGGCGCGGAATAAATTCGCACGCAAGAGTGTCCAGAAGAGTGTCCACTCGTAAAAAGATTTCGAGGACGAAGGAAGAGCCCGAGCAAAAGAAAGTTAAGAAAGGTCTGCGTCAAAGGGAGAAGGAGAGAATTCTCTGCGAGATGTGCCGCACGCGCGTGAGGAGGCCTCAAATGGGTAAACATTTGCTTTCCCATTACCATTGCCGTGTGTCAGGTGTCCTCGTGAATCCACGCAATCCAAGCGTACGCCGTTTCCTTCTGGAGCACATAGCGAACGTGGTTCGACAAAGCCCCTTCCAATGTGCTTCTTGTCGTTTTTACTGCAACACCGAGGAGACGTTTCTGCTTCATTGGCGTTCCGATCTTCACTCTAAGACCGTAGAACAGaTCAGCGGCAGTTGCCGATGCACTCCGTGTAACTTCTGGTGCGCAGACAACGCGACAATGGAGTCTCACCTTCTAAGTACGAGTCATCGTGACGTCGTATCGATGATGAAGGGTTCCGTGCCGGTGGTAATTAGTCGTCAACGTATGTTATCCTGCTGCAGTTGTGATCGGCAATTTCAATACAACTTCCAGCTGCGGTTGCACGCCAAAGAGACTGGTCACACCGTGAGCCATACCGCGTCGGACGTGTATCAACAGCGCATGAAGTGCGATATATGCTCCCAAGTCCTCCGGTCCTTAGTCGCGCTTCAGCGTCATCAGCTGACCAGTCACATCGCCAAGGACAAAGAGAAAGGCGAGATCGCGACAGACGCGCGACCAGCGCCGTACTTCTGTTCCTTCTGTTTGATGAACTTCACTACCGCCCAAGAAGCAGTTCTGCATCGGAGAACCACTAGTCACAAGGAAGCCGTAAAAGCACGCAAAAGCGAGGCAGGTCTATTAGACACAGTGCGGGAGTGTCCTCACTGTGATCAAAAGCAGCCGAATCTCGCGGCGCATAAGAGTCATCTTCTTCTTTGTCATCCAGAGCTTTGCCATCgATGTCCTCGATGTGGCACGCTTTTCGCCCTGTCACAAGACGTCACTAGGCACACGCGAGAAGGTAATTGTTTGAAGAACGATGCACTGAACGCTGCTGAAACTGAAAGTAACGAGAAAGAATGGAAATGTAAGGAGTGCATCTTTTCCACGGATTCCAAAGCCGAATTCATTTTTCACGAAGCCCTGCATACCGGTGCCGTTCAAGAAACGGATAAAAAGACTTCGAGCAAATTGCCGAAATATAAGTGCCCGACTTGTGCGAAGATTTTCCCGAAACCATCACTACGAAATCACATTAGGCAGCATACTGGAGAAAAACCCTTTTCATGTATGAAGTGTTCGATCTCATTCTCGAGAAGATCGCACCTCATTATTCATCAGAGGATATGCAATACTTCGTCGAAATCTCTGGACAAAACTGGTCGTCGGCGGAACTTCATCTGTTCGCATTGCAAAGAAGGCTTCTACACAAAACATGCCCTTCGACAGCACATGCTGCGACACGCTGGTAAGAAGTACAAGTGTGGCCTTCCGGGTTGTCCAACGATTCTTCGTACTGCAACCGAGCTCAAGACCCATCGAAGGTTGGTCCATGACAACATTGAGAAGCAGTATTCATGCCCTGATTGCTCTTACGCGGCTAAAACGAAAACCCAATTGCGCAGGCACAGAATACGGCACGAAGATTCCGCGAACACCGAGAAGGTTCAAATCCATTCCTGCACTTATAAAGGCTGCAATTTTAAGACGAAACTCGGTTCGAATCTGCGGAGACACGTGCGACTGCATACAGGTGTCAAACCATACAAGTGTCGACATTGTTCCTACGCCAGTAATACTTTgGAAAATCTTCGGAAGCACATACTATCGACGAATCTACATCCGGGTAAAACAATCTACGAATgcgaattttgcaaaaaggaaaaagaaaaaaagacggTTCCATTCTGTACGAATTTTGCCAAAGAACTTCGTGCTCACCTGCTGGAAGCTCACATTGAAGACTTTCCTACACCAAATGATGCGAACAACtatacaaataacatttttaaaccaaattaa
Protein Sequence
MEGYEEDDDTHFCIKCNLTIHGLDNYVQHRRSGCRPSDAKIEMVHEPPSTPTTVSYPECLNADAFFSSLELQSNTRQRATTLLDNRKFKKDDKRKKDQKGQVDGDEPGTKDKLHSMLPAVSDLDEPPDLCIQSLKPTTLERKRHENQQSWLDDTILADLSLGNSANKKLARYDFEYDDSEDDILEGELGEDSYSDSDDGENPREGPPRDHTGGKWKPGLDDLPQDTPHMHEEDAAEPDNDHQEHPPPTYTGGKWRPAETSQKVEEYESKDTSGQPPPGYTRGKWVPGARTDIESGYWCNPCGRKLASRLVYNRHLLSDLHARRSIRELDGGALHLRRGINSHARVSRRVSTRKKISRTKEEPEQKKVKKGLRQREKERILCEMCRTRVRRPQMGKHLLSHYHCRVSGVLVNPRNPSVRRFLLEHIANVVRQSPFQCASCRFYCNTEETFLLHWRSDLHSKTVEQISGSCRCTPCNFWCADNATMESHLLSTSHRDVVSMMKGSVPVVISRQRMLSCCSCDRQFQYNFQLRLHAKETGHTVSHTASDVYQQRMKCDICSQVLRSLVALQRHQLTSHIAKDKEKGEIATDARPAPYFCSFCLMNFTTAQEAVLHRRTTSHKEAVKARKSEAGLLDTVRECPHCDQKQPNLAAHKSHLLLCHPELCHRCPRCGTLFALSQDVTRHTREGNCLKNDALNAAETESNEKEWKCKECIFSTDSKAEFIFHEALHTGAVQETDKKTSSKLPKYKCPTCAKIFPKPSLRNHIRQHTGEKPFSCMKCSISFSRRSHLIIHQRICNTSSKSLDKTGRRRNFICSHCKEGFYTKHALRQHMLRHAGKKYKCGLPGCPTILRTATELKTHRRLVHDNIEKQYSCPDCSYAAKTKTQLRRHRIRHEDSANTEKVQIHSCTYKGCNFKTKLGSNLRRHVRLHTGVKPYKCRHCSYASNTLENLRKHILSTNLHPGKTIYECEFCKKEKEKKTVPFCTNFAKELRAHLLEAHIEDFPTPNDANNYTNNIFKPN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01423280;
90% Identity
iTF_01523658;
80% Identity
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