Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.2e-14 1.1e-10 40.7 7.0 4 67 90 152 87 155 0.89

2 3 2 7.1e+03 -3.5 0.1 10 23 189 202 188 205 0.71

3 3 0.61 2.1e+03 -1.8 0.3 50 63 300 313 297 313 0.59

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.2e-14	1.1e-10	40.7	7.0	4	67	90	152	87	155	0.89
2	3	2	7.1e+03	-3.5	0.1	10	23	189	202	188	205	0.71
3	3	0.61	2.1e+03	-1.8	0.3	50	63	300	313	297	313	0.59

Coding Sequence: ATGCCAGAAGAAAGCTGTGCCAACGCTTCATACGCGTGGCAACAAACTGACGACTTCACATATCGGAGTCCTTTCCCTTTGCCTTTTCGGAAAGCAACACGCTTTTGTAAATCACAAAGGACGGAATGTAAGCGGAGCGGGCCGTCACAAAGTGGCATGTTGTTCCCGTGGATTCCGACACTGAAAGCAACCGATGGTAAAGCTCGCGCGCCGAAACGACCGAACAATGTCTTCTCCACGAAAGttgAAACATGGAAATATCACAACGAATCAATTCGTTGTCCTGCGTGTGGAGTGAAAAAGATGCCGATAGTACTAAAACAACAACAATTCACGAGTTCTCGTCTGGTTGCATTTTGCTTAATGGGATGTTGGCCCTTCTGCTTCATACCGTTACTGATGAGACGGGACAAAAGTGTGCGCACGCTATGCCCGAGTTGCGGTCACGATTATGGGATTTGTACGCGAGCAGAGAGCAAGCTGGTTGCCTGTTCGCCCAAATACACGTCTAGTCGAGGGAAATTgaacaattttgcaaattcacgACTGTGTCATCTTCAGACTGAGTGCGACTCGAGAGTACAATCGAGATATCGCCAGAAAACACTTTCCATGGATGACGAGGCCGCGAGAGCTCTCAGGGTCTTGAAGGAACGTCCTCGGCGAAGAGAAGAAGTAAAAGAAGGCGGATCTCGTCACTGCCGGTCGCAATCGAAGTTATCGCACGAATACGCCTTTTGTGCAAACCAGGTCACGAATCGCGATTCGTCGTACGACGAGTGTAGCAGTGACGATTGCGTGGACAAAAGATGGGATCGTTGGCGCGACTTGAATAAATCGAAAACTCCAAAAACTTGGGGACAAAGCAAATCCAAAGAAAGCATGGAGATAGCGATGGACGATTTTTATGCAAGACAGGTTTGCTGTCGGGAGTGCGGCTAA
Protein Sequence: MPEESCANASYAWQQTDDFTYRSPFPLPFRKATRFCKSQRTECKRSGPSQSGMLFPWIPTLKATDGKARAPKRPNNVFSTKVETWKYHNESIRCPACGVKKMPIVLKQQQFTSSRLVAFCLMGCWPFCFIPLLMRRDKSVRTLCPSCGHDYGICTRAESKLVACSPKYTSSRGKLNNFANSRLCHLQTECDSRVQSRYRQKTLSMDDEAARALRVLKERPRRREEVKEGGSRHCRSQSKLSHEYAFCANQVTNRDSSYDECSSDDCVDKRWDRWRDLNKSKTPKTWGQSKSKESMEIAMDDFYARQVCCRECG

Sequence clustering based on sequence similarity using MMseqs2