Basic Information

Gene Symbol
e2f8
Assembly
GCA_036873485.1
Location
JAYJLV010000027.1:6375093-6377420[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 3.9 5.7e+04 -4.1 0.0 4 20 39 55 38 60 0.74
2 3 2.7e-25 4e-21 76.5 0.0 1 65 75 143 75 143 0.94
3 3 3.2e-19 4.7e-15 57.0 0.4 2 57 212 287 211 302 0.89

Sequence Information

Coding Sequence
ATGTCGAGCCAGAATGAGAATAGATCAACACCGGAGCGTAGAGTCCTGGGGGAGCTAGGAAATAATCCTGACTCACCTACTGCCAATCTCAGACTGCTCACTACTCTTGCGTCCAGTTTGAAGAATGCTACAGATAATGCCTGCCAGGACTGCTCGAGCTCCAGCAATGTTGTACAGGTGGCACCTGTTCAGGATTCCGGGTGCCTCAAACTTCTGCCTAGGAAGGAAAAGTCTCTTAGTCTTTTATGCgaaaagtttttaaatttattccctTTAAAAATCAGAGATAATGCTCCAAAGGAAATTTCTCTTAATACAACTGCCCAAGCTCTTGGTACTGAAAAACGAAGAATATATGACATAATAAATGTTTTGGAAAGCTTGGAAATGGCTTCCAAGGCTGGCAAAAACCAATATTATTGGCATGGTGATTCACGATTATCAACAACgcttgcaaaattaaaaatgcaagcTATTGAACTTGGATTAGAAAAGCAAATCCAAGAAATACAGAAAATCAATAGAGCCTATATAGAAAATTCTTGTCAATCTTGCAGTACCGCATCAACTTCTTTAATGGTCCCTCAGAGTCCAGTCATAGATTATTGCTTTCCAGAGGGTAATGTTAAAGAAGATAAGAGTTTGGGTGTCATGTGTAGAAAATTTGTAATGCTGTTTCTTGTTTCTTTAAAGAATGGtgttataaatttagatatagcagcaaaagttttaattaatgagCATGATGGTTCTTTAGATTCAAAGAACAGTACTATGCAATCACGATATAAGACAAAAGTTAGACGACTTTATGACATTGCAAATGTATTATCAGCTATACGTTTGATAGAAAAAGTTGATATATATAACTGTGTCATTAGAAAACCAATTTTTAGATATAGAGGACCAATTGTTGACTGCCTTAATTTTGATGCTgaaaCTCCAACCACTGAGAATGCAAGTCAATCACTGGTAGGAATGACTAcaccaaataaaaaatcatctgaTACTTCAAATTTTCGTGCCTTAAGCAGGCTTTCCACATTTGGCAGAAGATTAATTACAAGCACGccaattgtaaataaaagagatACAAGAAAACGAAAACTTTTTGTCACAGacAACAAATTTGAAAGAACTCAAAGTTCGCCGTGCCTGAGTACAGCCAAGAGACGTAGCATGGACCGCTTAGACGATTCGATTCTCAAAGTAGCCGAAATGGAGCTCAAGCGAATGAGGTCCAGCGAGAACAAGCCAAAAGTCTGCACGAAACTATTCCCCCGTCACAATTCCGACTCCTGCATCTCACCCTCGAAGCTCGACACGAGTACAACCGACTCCGAGGAGTCACTTCGTAGTATTGTGGCCTCGACACCTTCGACCTCGAGTGAGCAGTCCAGCTCCATAATCCTCGATAGCAGCATCTCCCCGCCGCCCATCACACTTCCAGTAGTTAGTAAAGAAAATCATCTAGTCAGCGAAACGCAAAAGCTCGGTGTGACGTCGGCACCCATTCGCACGTTGTGTATAAACGTGCCGCTCGAGCTGAAAATCGCGCCGTTCTCAGCGCTCCAAAATCACCGACGCATCGGTCAGCCGAAATTCGTCAAACTTACGAATTTCGATATGAAGAAGTTGGTGCCTATCTCGAAAGAAGATCTTAGGATCAAATTACCGTTGCAGTCGACAGTGGCGACGAGTAGTAAATGCGCCGTAGTGCAGAAGCCAAATATCGCGATTCTGGCGCAAATgccgaataaaaaaatttgcccGGGTGATACATTTAAGGCAGTGAAGGTCGGCAATACCTTCCAGCTAGTACCGCTCGAGCGTACGAGTGATTAG
Protein Sequence
MSSQNENRSTPERRVLGELGNNPDSPTANLRLLTTLASSLKNATDNACQDCSSSSNVVQVAPVQDSGCLKLLPRKEKSLSLLCEKFLNLFPLKIRDNAPKEISLNTTAQALGTEKRRIYDIINVLESLEMASKAGKNQYYWHGDSRLSTTLAKLKMQAIELGLEKQIQEIQKINRAYIENSCQSCSTASTSLMVPQSPVIDYCFPEGNVKEDKSLGVMCRKFVMLFLVSLKNGVINLDIAAKVLINEHDGSLDSKNSTMQSRYKTKVRRLYDIANVLSAIRLIEKVDIYNCVIRKPIFRYRGPIVDCLNFDAETPTTENASQSLVGMTTPNKKSSDTSNFRALSRLSTFGRRLITSTPIVNKRDTRKRKLFVTDNKFERTQSSPCLSTAKRRSMDRLDDSILKVAEMELKRMRSSENKPKVCTKLFPRHNSDSCISPSKLDTSTTDSEESLRSIVASTPSTSSEQSSSIILDSSISPPPITLPVVSKENHLVSETQKLGVTSAPIRTLCINVPLELKIAPFSALQNHRRIGQPKFVKLTNFDMKKLVPISKEDLRIKLPLQSTVATSSKCAVVQKPNIAILAQMPNKKICPGDTFKAVKVGNTFQLVPLERTSD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_01464833;
80% Identity
-